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Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Increased global nitrous oxide emissions from streams and rivers in the Anthropocene 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (2) : 138-+
作者:  Yao, Yuanzhi;  Tian, Hanqin;  Shi, Hao;  Pan, Shufen;  Xu, Rongting;  Pan, Naiqing;  Canadell, Josep G.
收藏  |  浏览/下载：15/0  |  提交时间：2020/02/16
Ultrahigh-energy density lead-free dielectric films via polymorphic nanodomain design 期刊论文
SCIENCE, 2019, 365 (6453) : 578-582
作者:  Pan, Hao;  Li, Fei;  Liu, Yao;  Zhang, Qinghua;  Wang, Meng;  Lan, Shun;  Zheng, Yunpeng;  Ma, Jing;  Gu, Lin;  Shen, Yang;  Yu, Pu;  Zhang, Shujun;  Chen, Long-Qing;  Lin, Yuan-Hua;  Nan, Ce-Wen
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Generation of multicomponent atomic Schrodinger cat states of up to 20 qubits 期刊论文
SCIENCE, 2019, 365 (6453) : 574-577
作者:  Song, Chao;  Xu, Kai;  Li, Hekang;  Zhang, Yu-Ran;  Zhang, Xu;  Liu, Wuxin;  Guo, Qiujiang;  Wang, Zhen;  Ren, Wenhui;  Hao, Jie;  Feng, Hui;  Fan, Heng;  Zheng, Dongning;  Wang, Da-Wei;  Wang, H.;  Zhu, Shi-Yao
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Estimating the influence of transport on aerosol size distributions during new particle formation events 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (22) : 16587-16599
作者:  Cai, Runlong;  Chandra, Indra;  Yang, Dongsen;  Yao, Lei;  Fu, Yueyun;  Li, Xiaoxiao;  Lu, Yiqun;  Luo, Lun;  Hao, Jiming;  Ma, Yan;  Wang, Lin;  Zheng, Jun;  Seto, Takafumi;  Jiang, Jingkun
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Recently amplified arctic warming has contributed to a continual global warming trend (vol 7, pg 875, 2017) 期刊论文
NATURE CLIMATE CHANGE, 2018, 8 (4) : 345-345
作者:  Huang, Jianbin;  Zhang, Xiangdong;  Zhang, Qiyi;  Lin, Yanluan;  Hao, Mingju;  Luo, Yong;  Zhao, Zongci;  Yao, Yao;  Chen, Xin;  Wang, Lei;  Nie, Suping;  Yin, Yizhou;  Xu, Ying;  Zhang, Jiansong
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
Gaseous elemental mercury (GEM) fluxes over canopy of two typical subtropical forests in south China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (1) : 495-509
作者:  Yu, Qian;  Luo, Yao;  Wang, Shuxiao;  Wang, Zhiqi;  Hao, Jiming;  Duan, Lei
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Recently amplified arctic warming has contributed to a continual global warming trend 期刊论文
NATURE CLIMATE CHANGE, 2017, 7 (12)
作者:  Huang, Jianbin;  Zhang, Xiangdong;  Zhang, Qiyi;  Lin, Yanluan;  Hao, Mingju;  Luo, Yong;  Zhao, Zongci;  Yao, Yao;  Chen, Xin;  Wang, Lei;  Nie, Suping;  Yin, Yizhou;  Xu, Ying;  Zhang, Jiansong
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Lv, Jian-Ming;  Hu, Dan;  Gao, Hao;  Kushiro, Tetsuo;  Awakawa, Takayoshi;  Chen, Guo-Dong;  Wang, Chuan-Xi;  Abe, Ikuro;  Yao, Xin-Sheng
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
The role of fog in haze episode in Tianjin, China: A case study for November 2015 期刊论文
ATMOSPHERIC RESEARCH, 2017, 194
作者:  Hao, Tianyi;  Han, Suqin;  Chen, Shucheng;  Shan, Xiaolin;  Zai, Ziying;  Qiu, Xiaobin;  Yao, Qing;  Liu, Jingle;  Chen, Jing;  Meng, Lihong
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09
Tianjin  Haze  Fog  Turbulence  Dissipation mechanism