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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Novel approaches to improve estimates of short-lived halocarbon emissions during summer from the Southern Ocean using airborne observations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (22) : 14071-14090
作者:  Asher, Elizabeth;  Hornbrook, Rebecca S.;  Stephens, Britton B.;  Kinnison, Doug;  Morgan, Eric J.;  Keeling, Ralph F.;  Atlas, Elliot L.;  Schauffler, Sue M.;  Tilmes, Simone;  Kort, Eric A.;  Hoecker-Martinez, Martin S.;  Long, Matt C.;  Lamarque, Jean-Francois;  Saiz-Lopez, Alfonso;  McKain, Kathryn;  Sweeney, Colm;  Hills, Alan J.;  Apel, Eric C.
收藏  |  浏览/下载：8/0  |  提交时间：2020/02/17
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions (vol 9, 4079, 2018) 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Mancuso, Nicholas;  Gayther, Simon;  Gusev, Alexander;  Zheng, Wei;  Penney, Kathryn L.;  Kote-Jarai, Zsofia;  Eeles, Rosalind;  Freedman, Matthew;  Haiman, Christopher;  Pasaniuc, Bogdan;  Henderson, Brian E.;  Benlloch, Sara;  Schumacher, Fredrick R.;  Al Olama, Ali Amin;  Muir, Kenneth;  Berndt, Sonja I.;  Conti, David V.;  Wiklund, Fredrik;  Chanock, Stephen;  Stevens, Victoria L.;  Tangen, Catherine M.;  Batra, Jyotsna;  Clements, Judith;  Gronberg, Henrik;  Pashayan, Nora;  Schleutker, Johanna;  Albanes, Demetrius;  Weinstein, Stephanie;  Wolk, Alicja;  West, Catharine;  Mucci, Lorelei;  Cancel-Tassin, Geraldine;  Koutros, Stella;  Sorensen, Karina Dalsgaard;  Maehle, Lovise;  Neal, David E.;  Hamdy, Freddie C.;  Donovan, Jenny L.;  Travis, Ruth C.;  Hamilton, Robert J.;  Ingles, Sue Ann;  Rosenstein, Barry;  Lu, Yong-Jie;  Giles, Graham G.;  Kibel, Adam S.;  Vega, Ana;  Kogevinas, Manolis;  Park, Jong Y.;  Stanford, Janet L.;  Cybulski, Cezary;  Nordestgaard, Borge G.;  Brenner, Hermann;  Maier, Christiane;  Kim, Jeri;  John, Esther M.;  Teixeira, Manuel R.;  Neuhausen, Susan L.;  De Ruyck, Kim;  Razack, Azad;  Newcomb, Lisa F.;  Lessel, Davor;  Kaneva, Radka;  Usmani, Nawaid;  Claessens, Frank;  Townsend, Paul A.;  Gago-Dominguez, Manuela;  Roobol, Monique J.;  Menegaux, Florence;  Khaw, Kay-Tee;  Cannon-Albright, Lisa;  Pandha, Hardev;  Thibodeau, Stephen N.;  Hunter, David J.;  Kraft, Peter
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/27
Interpretation of particle number size distributions measured across an urban area during the FASTER campaign 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (1) : 39-55
作者:  Harrison, Roy M.;  Beddows, David C. S.;  Alam, Mohammed S.;  Singh, Ajit;  Brean, James;  Xu, Ruixin;  Kotthaus, Simone;  Grimmond, Sue
收藏  |  浏览/下载：24/0  |  提交时间：2019/04/09
Stratospheric Injection of Brominated Very Short-Lived Substances: Aircraft Observations in the Western Pacific and Representation in Global Models 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (10) : 5690-5719
作者:  Wales, Pamela A.;  Salawitch, Ross J.;  Nicely, Julie M.;  Anderson, Daniel C.;  Canty, Timothy P.;  Baidar, Sunil;  Dix, Barbara;  Koenig, Theodore K.;  Volkamer, Rainer;  Chen, Dexian;  Huey, L. Gregory;  Tanner, David J.;  Cuevas, Carlos A.;  Fernandez, Rafael P.;  Kinnison, Douglas E.;  Lamarque, Jean-Francois;  Saiz-Lopez, Alfonso;  Atlas, Elliot L.;  Hall, Samuel R.;  Navarro, Maria A.;  Pan, Laura L.;  Schauffler, Sue M.;  Stell, Meghan;  Tilmes, Simone;  Ullmann, Kirk;  Weinheimer, Andrew J.;  Akiyoshi, Hideharu;  Chipperfield, Martyn P.;  Deushi, Makoto;  Dhomse, Sandip S.;  Feng, Wuhu;  Graf, Phoebe;  Hossaini, Ryan;  Joeckel, Patrick;  Mancini, Eva;  Michou, Martine;  Morgenstern, Olaf;  Oman, Luke D.;  Pitari, Giovanni;  Plummer, David A.;  Revell, Laura E.;  Rozanov, Eugene;  Saint-Martin, David;  Schofield, Robyn;  Stenke, Andrea;  Stone, Kane A.;  Visioni, Daniele;  Yamashita, Yousuke;  Zeng, Guang
收藏  |  浏览/下载：16/0  |  提交时间：2019/04/09
bromine  CONTRAST  CCMI  VSLS  
BrO and inferred Br-y profiles over the western Pacific: relevance of inorganic bromine sources and a Br-y minimum in the aged tropical tropopause layer 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (24)
作者:  Koenig, Theodore K.;  Volkamer, Rainer;  Baidar, Sunil;  Dix, Barbara;  Wang, Siyuan;  Anderson, Daniel C.;  Salawitch, Ross J.;  Wales, Pamela A.;  Cuevas, Carlos A.;  Fernandez, Rafael P.;  Saiz-Lopez, Alfonso;  Evans, Mathew J.;  Sherwen, Tomas;  Jacob, Daniel J.;  Schmidt, Johan;  Kinnison, Douglas;  Lamarque, Jean-Francois;  Apel, Eric C.;  Bresch, James C.;  Campos, Teresa;  Flocke, Frank M.;  Hall, Samuel R.;  Honomichl, Shawn B.;  Hornbrook, Rebecca;  Jensen, Jorgen B.;  Lueb, Richard;  Montzka, Denise D.;  Pan, Laura L.;  Reeves, J. Michael;  Schauffler, Sue M.;  Ullmann, Kirk;  Weinheimer, Andrew J.;  Atlas, Elliot L.;  Donets, Valeria;  Navarro, Maria A.;  Riemer, Daniel;  Blake, Nicola J.;  Chen, Dexian;  Huey, L. Gregory;  Tanner, David J.;  Hanisco, Thomas F.;  Wolfe, Glenn M.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
Ecological regime shift drives declining growth rates of sea turtles throughout the West Atlantic 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (11)
作者:  Bjorndal, Karen A.;  Bolten, Alan B.;  Chaloupka, Milani;  Saba, Vincent S.;  Bellini, Claudio;  Marcovaldi, Maria A. G.;  Santos, Armando J. B.;  Wurdig Bortolon, Luis Felipe;  Meylan, Anne B.;  Meylan, Peter A.;  Gray, Jennifer;  Hardy, Robert;  Brost, Beth;  Bresette, Michael;  Gorham, Jonathan C.;  Connett, Stephen;  Crouchley, Barbara Van Sciver;  Dawson, Mike;  Hayes, Deborah;  Diez, Carlos E.;  van Dam, Robert P.;  Willis, Sue;  Nava, Mabel;  Hart, Kristen M.;  Cherkiss, Michael S.;  Crowder, Andrew G.;  Pollock, Clayton;  Hillis-Starr, Zandy;  Munoz Teneria, Fernando A.;  Herrera-Pavon, Roberto;  Labrada-Martagon, Vanessa;  Lorences, Armando;  Negrete-Philippe, Ana;  Lamont, Margaret M.;  Foley, Allen M.;  Bailey, Rhonda;  Carthy, Raymond R.;  Scarpino, Russell;  McMichael, Erin;  Provancha, Jane A.;  Brooks, Annabelle;  Jardim, Adriana;  Lopez-Mendilaharsu, Milagros;  Gonzalez-Paredes, Daniel;  Estrades, Andres;  Fallabrino, Alejandro;  Martinez-Souza, Gustavo;  Velez-Rubio, Gabriela M.;  Boulon, Ralf H.;  Collazo, Jaime A.;  Wershoven, Robert;  Guzman Hernandez, Vicente;  Stringell, Thomas B.;  Sanghera, Amdeep;  Richardson, Peter B.;  Broderick, Annette C.;  Phillips, Quinton;  Calosso, Marta;  Claydon, John A. B.;  Metz, Tasha L.;  Gordon, Amanda L.;  Landry, Andre M.;  Shaver, Donna J.;  Blumenthal, Janice;  Collyer, Lucy;  Godley, Brendan J.;  McGowan, Andrew;  Witt, Matthew J.;  Campbell, Cathi L.;  Lagueux, Cynthia J.;  Bethel, Thomas L.;  Kenyon, Lory
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09
Caretta caretta  Chelonia mydas  ecological regime shifts  Eretmochelys imbricata  multivariate ENSO index  sea surface temperature  seagrass  somatic growth rates  
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution 期刊论文
NATURE, 2017, 545 (7655) : 446-+
作者:  Abbosh, Christopher;  Birkbak, Nicolai J.;  Wilson, Gareth A.;  Jamal-Hanjani, Mariam;  Constantin, Tudor;  Salari, Raheleh;  Le Quesne, John;  Moore, David A.;  Veeriah, Selvaraju;  Rosenthal, Rachel;  Marafioti, Teresa;  Kirkizlar, Eser;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Ward, Sophia;  Martinson, Luke;  Riley, Joan;  Fraioli, Francesco;  Al Bakir, Maise;  Gronroos, Eva;  Zambrana, Francisco;  Endozo, Raymondo;  Bi, Wenya Linda;  Fennessy, Fiona M.;  Sponer, Nicole;  Johnson, Diana;  Laycock, Joanne;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Rowan, Andrew;  Chambers, Tim;  Matthews, Nik;  Turajlic, Samra;  Hiley, Crispin;  Lee, Siow Ming;  Forster, Martin D.;  Ahmad, Tanya;  Falzon, Mary;  Borg, Elaine;  Lawrence, David;  Hayward, Martin;  Kolvekar, Shyam;  Panagiotopoulos, Nikolaos;  Janes, Sam M.;  Thakrar, Ricky;  Ahmed, Asia;  Blackhall, Fiona;  Summers, Yvonne;  Hafez, Dina;  Naik, Ashwini;  Ganguly, Apratim;  Kareht, Stephanie;  Shah, Rajesh;  Joseph, Leena;  Quinn, Anne Marie;  Crosbie, Phil A.;  Naidu, Babu;  Middleton, Gary;  Langman, Gerald;  Trotter, Simon;  Nicolson, Marianne;  Remmen, Hardy;  Kerr, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Fennell, Dean A.;  Nakas, Apostolos;  Rathinam, Sridhar;  Anand, Girija;  Khan, Sajid;  Russell, Peter;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Lester, Jason F.;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Adams, Haydn;  Davies, Helen;  Oukrif, Dahmane;  Akarca, Ayse U.;  Hartley, John A.;  Lowe, Helen L.;  Lock, Sara;  Iles, Natasha;  Bell, Harriet;  Ngai, Yenting;  Elgar, Greg;  Szallasi, Zoltan;  Schwarz, Roland F.;  Herrero, Javier;  Stewart, Aengus;  Quezada, Sergio A.;  Peggs, Karl S.;  Van Loo, Peter;  Dive, Caroline;  Lin, C. Jimmy;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Hackshaw, Allan;  Shaw, Jacqui A.;  Zimmermann, Bernhard G.;  Swanton, Charles;  Jamal-Hanjani, Mariam;  Abbosh, Christopher;  Veeriah, Selvaraju;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Johnson, Diana;  Laycock, Joanne;  Bosshard-Carter, Leticia;  Goh, Gerald;  Rosenthal, Rachel;  Gorman, Pat;  Murugaesu, Nirupa;  Hynds, Robert E.;  Wilson, Gareth A.;  Birkbak, Nicolai J.;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Horswell, Stuart;  Al Bakir, Maise;  Gronroos, Eva;  Mitter, Richard;  Escudero, Mickael;  Stewart, Aengus;  Van Loo, Peter;  Rowan, Andrew;  Xu, Hang;  Turajlic, Samra;  Hiley, Crispin;  Goldman, Jacki;  Stone, Richard Kevin;  Denner, Tamara;  Matthews, Nik;  Elgar, Greg;  Ward, Sophia;  Biggs, Jennifer;  Costa, Marta;  Begum, Sharmin;  Phillimore, Ben;  Chambers, Tim;  Nye, Emma;  Graca, Sofia;  Joshi, Kroopa;  Furness, Andrew;  Ben Aissa, Assma;  Wong, Yien Ning Sophia;  Georgiou, Andy;  Quezada, Sergio A.;  Peggs, Karl S.;  Hartley, John A.;  Lowe, Helen L.;  Herrero, Javier;  Lawrence, David;  Hayward, Martin;  Panagiotopoulos, Nikolaos;  Kolvekar, Shyam;  Falzon, Mary;  Borg, Elaine;  Marafioti, Teresa;  Simeon, Celia;  Hector, Gemma;  Smith, Amy;  Aranda, Marie;  Novelli, Marco;  Oukrif, Dahmane;  Akarca, Ayse U.;  Janes, Sam M.;  Thakrar, Ricky;  Forster, Martin D.;  Ahmad, Tanya;  Lee, Siow Ming;  Papadatos-Pastos, Dionysis;  Carnell, Dawn;  Mendes, Ruheena;  George, Jeremy;  Navani, Neal;  Ahmed, Asia;  Taylor, Magali;  Choudhary, Junaid;  Summers, Yvonne;  Califano, Raffaele;  Taylor, Paul;  Shah, Rajesh;  Krysiak, Piotr;  Rammohan, Kendadai;  Fontaine, Eustace;  Booton, Richard;  Evison, Matthew;  Crosbie, Phil A.;  Moss, Stuart;  Idries, Faiza;  Joseph, Leena;  Bishop, Paul;  Chaturvedi, Anshuman;  Quinn, Anne Marie;  Doran, Helen;  Leek, Angela;  Harrison, Phil;  Moore, Katrina;  Waddington, Rachael;  Novasio, Juliette;  Blackhall, Fiona;  Rogan, Jane;  Smith, Elaine;  Dive, Caroline;  Tugwood, Jonathan;  Brady, Ged;  Rothwell, Dominic G.;  Chemi, Francesca;  Pierce, Jackie;  Gulati, Sakshi;  Naidu, Babu;  Langman, Gerald;  Trotter, Simon;  Bellamy, Mary;  Bancroft, Hollie;  Kerr, Amy;  Kadiri, Salma;  Webb, Joanne;  Middleton, Gary;  Djearaman, Madava;  Fennell, Dean A.;  Shaw, Jacqui A.;  Le Quesne, John;  Moore, David A.;  Thomas, Anne;  Walter, Harriet;  Riley, Joan;  Martinson, Luke;  Nakas, Apostolos;  Rathinam, Sridhar;  Monteiro, William;  Marshall, Hilary;  Nelson, Louise;  Bennett, Jonathan;  Primrose, Lindsay;  Anand, Girija;  Khan, Sajid;  Amadi, Anita;  Nicolson, Marianne;  Kerr, Keith;  Palmer, Shirley;  Remmen, Hardy;  Miller, Joy;  Buchan, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Lester, Jason F.;  Edwards, Alison;  Morgan, Fiona;  Adams, Haydn;  Davies, Helen;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Lock, Sara;  Verjee, Azmina;  MacKenzie, Mairead;  Wilcox, Maggie;  Bell, Harriet;  Iles, Natasha;  Hackshaw, Allan;  Ngai, Yenting;  Smith, Sean;  Gower, Nicole;  Ottensmeier, Christian;  Chee, Serena;  Johnson, Benjamin;  Alzetani, Aiman;  Shaw, Emily;  Lim, Eric;  De Sousa, Paulo;  Barbosa, Monica Tavares;  Bowman, Alex;  Jordan, Simon;  Rice, Alexandra;  Raubenheimer, Hilgardt;  Proli, Chiara;  Cufari, Maria Elena;  Ronquillo, John Carlo;  Kwayie, Angela;  Bhayani, Harshil;  Hamilton, Morag;  Bakar, Yusura;  Mensah, Natalie;  Ambrose, Lyn;  Devaraj, Anand;  Buderi, Silviu;  Finch, Jonathan;  Azcarate, Leire;  Chavan, Hema;  Green, Sophie;  Mashinga, Hillaria;  Nicholson, Andrew G.;  Lau, Kelvin;  Sheaff, Michael;  Schmid, Peter;  Conibear, John;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Russell, Peter;  Light, Teresa;  Horey, Tracey;  Danson, Sarah;  Bury, Jonathan;  Edwards, John;  Hill, Jennifer;  Matthews, Sue;  Kitsanta, Yota;  Suvarna, Kim;  Fisher, Patricia;  Keerio, Allah Dino;  Shackcloth, Michael;  Gosney, John;  Postmus, Pieter;  Feeney, Sarah;  Asante-Siaw, Julius;  Constantin, Tudor;  Salari, Raheleh;  Sponer, Nicole;  Naik, Ashwini;  Zimmermann, Bernhard G.;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Dentro, Stefan;  Dessimoz, Christophe
收藏  |  浏览/下载：25/0  |  提交时间：2019/04/09
Simulation of groundwater storage changes in the eastern Pasco Basin, Washington 科技报告
来源：US Geological Survey (USGS). 出版年： 2016
作者:  Heywood, Charles E.;  Kahle, Sue C. sckahle@usgs.gov;  Olsen, Theresa D. tdolsen@usgs.gov;  Patterson, James D.;  Burns, Erick
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/05
Hydrogeologic framework and groundwater/surface-water interactions of the upper Yakima River Basin, Kittitas County, central Washington 科技报告
来源：US Geological Survey (USGS). 出版年： 2014
作者:  Gendaszek, Andrew S. agendasz@usgs.gov;  Ely, D. Matthew;  Hinkle, Stephen R. srhinkle@usgs.gov;  Kahle, Sue C. sckahle@usgs.gov;  Welch, Wendy B. wwelch@usgs.gov
收藏  |  浏览/下载：2/0  |  提交时间：2019/04/05