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Increase of High Molecular Weight Organosulfate With Intensifying Urban Air Pollution in the Megacity Beijing 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (10)
作者:  Xie, Qiaorong;  Li, Ying;  Yue, Siyao;  Su, Sihui;  Cao, Dong;  Xu, Yisheng;  Chen, Jing;  Tong, Haijie;  Su, Hang;  Cheng, Yafang;  Zhao, Wanyu;  Hu, Wei;  Wang, Zhe;  Yang, Ting;  Pan, Xiaole;  Sun, Yele;  Wang, Zifa;  Liu, Cong-Qiang;  Kawamura, Kimitaka;  Jiang, Guibin;  Shiraiwa, Manabu;  Fu, Pingqing
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/02
Organic aerosol  Organosulfates  FT-ICR MS  Secondary organic aerosol  Volatile organic compounds  
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:143/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
N-6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication 期刊论文
SCIENCE, 2019, 365 (6458) : 1171-+
作者:  Liu, Yang;  You, Yuling;  Lu, Zhike;  Yang, Jiang;  Li, Panpan;  Liu, Lun;  Xu, Henan;  Niu, Yamei;  Cao, Xuetao
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Internal Drainage Has Sustained Low-Relief Tibetan Landscapes Since the Early Miocene 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (15) : 8741-8752
作者:  Han, Zhongpeng;  Sinclair, Hugh D.;  Li, Yalin;  Wang, Chengshan;  Tao, Zui;  Qian, Xinyu;  Ning, Zijie;  Zhang, Jiawei;  Wen, Yixiong;  Lin, Jie;  Zhang, Baosen;  Xu, Ming;  Dai, Jingen;  Zhou, Aorigele;  Liang, Huimin;  Cao, Shuo
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Local Generation of High-Frequency Plasmaspheric Hiss Observed by Van Allen Probes 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (3) : 1141-1148
作者:  He, Zhaoguo;  Chen, Lunjin;  Liu, Xu;  Zhu, Hui;  Liu, Si;  Gao, Zhonglei;  Cao, Yong
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/26
Characteristics and Simulation Biases of Corkscrew Sea Breezes on the East Coast of China 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (1) : 18-34
作者:  Lin, Yanluan;  Cao, Dianbin;  Lin, Namei;  Xue, Wei;  Xu, Shiming;  Zhao, Yangyang;  Li, Heng;  Huang, Bin;  Guo, Jianping
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
sea breeze  wind power  WRF  China  
Ammonia emission control in China would mitigate haze pollution and nitrogen deposition, but worsen acid rain 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (16) : 7760-7765
作者:  Liu, Mingxu;  Huang, Xin;  Song, Yu;  Tang, Jie;  Cao, Junji;  Zhang, Xiaoye;  Zhang, Qiang;  Wang, Shuxiao;  Xu, Tingting;  Kang, Ling;  Cai, Xuhui;  Zhang, Hongsheng;  Yang, Fumo;  Wang, Huanbo;  Yu, Jian Zhen;  Lau, Alexis K. H.;  He, Lingyan;  Huang, Xiaofeng;  Duan, Lei;  Ding, Aijun;  Xue, Likun;  Gao, Jian;  Liu, Bin;  Zhu, Tong
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
ammonia emission  China  PM2.5  acid rain  nitrogen deposition  
Connections Between a Late Summer Snowstorm Over the Southwestern Tibetan Plateau and a Concurrent Indian Monsoon Low-Pressure System 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (24) : 13676-13691
作者:  Dong, Wenhao;  Lin, Yanluan;  Wright, Jonathon S.;  Xie, Yuanyu;  Xu, Fanghua;  Yang, Kun;  Li, Xin;  Tian, Lide;  Zhao, Xi;  Cao, Dianbin
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/09
summertime snowfall  southwestern Tibetan Plateau  tropical-extratropical interaction  upper-level trough  monsoon low-pressure system  
An Accurate Method for Correcting Spectral Convolution Errors in Intercalibration of Broadband and Hyperspectral Sensors 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (17) : 9238-9255
作者:  Wu, Wan;  Liu, Xu;  Xiong, Xiaoxiong;  Li, Yonghong;  Yang, Qiguang;  Wu, Aisheng;  Kizer, Susan;  Cao, Changyong
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
hyperspectral  intercalibration  MODIS  AIRS  IASI  CrIS  
Observation of Dicke cooperativity in magnetic interactions 期刊论文
SCIENCE, 2018, 361 (6404) : 794-796
作者:  Li, Xinwei;  Bamba, Motoaki;  Yuan, Ning;  Zhang, Qi;  Zhao, Yage;  Xiang, Maolin;  Xu, Kai;  Jin, Zuanming;  Ren, Wei;  Ma, Guohong;  Cao, Shixun;  Turchinovich, Dmitry;  Kono, Junichiro
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27