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Emergent constraint on crop yield response to warmer temperature from field experiments 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Wang, Xuhui;  Zhao, Chuang;  Mueller, Christoph;  Wang, Chenzhi;  Ciais, Philippe;  Janssens, Ivan;  Penuelas, Josep;  Asseng, Senthold;  Li, Tao;  Elliott, Joshua;  Huang, Yao;  Li, Laurent;  Piao, Shilong
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/06
The morphology, molecular development and ecological function of pseudonectaries on Nigella damascena (Ranunculaceae) petals 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Liao, Hong;  Fu, Xuehao;  Zhao, Huiqi;  Cheng, Jie;  Zhang, Rui;  Yao, Xu;  Duan, Xiaoshan;  Shan, Hongyan;  Kong, Hongzhi
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1 期刊论文
NATURE, 2020, 583 (7814) : 145-+
作者:  Jin, Zhenming;  Du, Xiaoyu;  Xu, Yechun;  Deng, Yongqiang;  Liu, Meiqin;  Zhao, Yao;  Zhang, Bing;  Li, Xiaofeng;  Zhang, Leike;  Peng, Chao;  Duan, Yinkai;  Yu, Jing;  Wang, Lin;  Yang, Kailin;  Liu, Fengjiang;  Jiang, Rendi;  Yang, Xinglou;  You, Tian;  Liu, Xiaoce
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/03

Voltage-gated potassium (K-v) channels coordinate electrical signalling and control cell volume by gating in response to membrane depolarization or hyperpolarization. However, although voltage-sensing domains transduce transmembrane electric field changes by a common mechanism involving the outward or inward translocation of gating charges(1-3), the general determinants of channel gating polarity remain poorly understood(4). Here we suggest a molecular mechanism for electromechanical coupling and gating polarity in non-domain-swapped K-v channels on the basis of the cryo-electron microscopy structure of KAT1, the hyperpolarization-activated K-v channel from Arabidopsis thaliana. KAT1 displays a depolarized voltage sensor, which interacts with a closed pore domain directly via two interfaces and indirectly via an intercalated phospholipid. Functional evaluation of KAT1 structure-guided mutants at the sensor-pore interfaces suggests a mechanism in which direct interaction between the sensor and the C-linker hairpin in the adjacent pore subunit is the primary determinant of gating polarity. We suggest that an inward motion of the S4 sensor helix of approximately 5-7 angstrom can underlie a direct-coupling mechanism, driving a conformational reorientation of the C-linker and ultimately opening the activation gate formed by the S6 intracellular bundle. This direct-coupling mechanism contrasts with allosteric mechanisms proposed for hyperpolarization-activated cyclic nucleotide-gated channels(5), and may represent an unexpected link between depolarization- and hyperpolarization-activated channels.


The cryo-electron microscopy structure of the hyperpolarization-activated K+ channel KAT1 points to a direct-coupling mechanism between S4 movement and the reorientation of the C-linker.


  
Nitrifier adaptation to low energy flux controls inventory of reduced nitrogen in the dark ocean 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (9) : 4823-4830
作者:  Zhang, Yao;  Qin, Wei;  Hou, Lei;  Zakem, Emily J.;  Wan, Xianhui;  Zhao, Zihao;  Liu, Li;  Hunt, Kristopher A.;  Jiao, Nianzhi;  Kao, Shuh-Ji;  Tang, Kai;  Xie, Xiabing;  Shen, Jiaming;  Li, Yufang;  Chen, Mingming;  Dai, Xiaofeng;  Liu, Chang;  Deng, Wenchao;  Dai, Minhan;  Ingalls, Anitra E.;  Stahl, David A.;  Herndl, Gerhard J.
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
nitrification  dark ocean  nitrogen flux  carbon fixation  homeostasis  
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells 期刊论文
NATURE, 2020, 577 (7792) : 676-+
作者:  Zhao, Ruozhu;  Chen, Xin;  Ma, Weiwei;  Zhang, Jinyu;  Guo, Jie;  Zhong, Xiu;  Yao, Jiacheng;  Sun, Jiahui;  Rubinfien, Julian;  Zhou, Xuyu;  Wang, Jianbin;  Qi, Hai
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs)(1,2), but so far there has been little scientific validation of this link. Here we report that, in mice, acute stress leads to hair greying through the fast depletion of melanocyte stem cells. Using a combination of adrenalectomy, denervation, chemogenetics(3,4), cell ablation and knockout of the adrenergic receptor specifically in melanocyte stem cells, we find that the stress-induced loss of melanocyte stem cells is independent of immune attack or adrenal stress hormones. Instead, hair greying results from activation of the sympathetic nerves that innervate the melanocyte stem-cell niche. Under conditions of stress, the activation of these sympathetic nerves leads to burst release of the neurotransmitter noradrenaline (also known as norepinephrine). This causes quiescent melanocyte stem cells to proliferate rapidly, and is followed by their differentiation, migration and permanent depletion from the niche. Transient suppression of the proliferation of melanocyte stem cells prevents stress-induced hair greying. Our study demonstrates that neuronal activity that is induced by acute stress can drive a rapid and permanent loss of somatic stem cells, and illustrates an example in which the maintenance of somatic stem cells is directly influenced by the overall physiological state of the organism.


Stress induces hair greying in mice through depletion of melanocyte stem cells, which is mediated by the activation of sympathetic nerves rather than through immune attack or adrenal stress hormones.


  
The histone methyltransferase Setd2 is indispensable for V(D)J recombination 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Ji, Zhongzhong;  Sheng, Yaru;  Miao, Juju;  Li, Xiaoxia;  Zhao, Huifang;  Wang, Jinming;  Cheng, Chaping;  Wang, Xue;  Liu, Kaiyuan;  Zhang, Kai;  Xu, Longmei;  Yao, Jufang;  Shen, Lijing;  Hou, Jian;  Zhou, Wenhao;  Sun, Jinqiao;  Li, Li;  Gao, Wei-Qiang;  Zhu, Helen He
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
A radiative cooling structural material 期刊论文
SCIENCE, 2019, 364 (6442) : 760-+
作者:  Li, Tian;  Zhai, Yao;  He, Shuaiming;  Gan, Wentao;  Wei, Zhiyuan;  Heidarinejad, Mohammad;  Dalgo, Daniel;  Mi, Ruiyu;  Zhao, Xinpeng;  Song, Jianwei;  Dai, Jiaqi;  Chen, Chaoji;  Aili, Ablimit;  Vellore, Azhar;  Martini, Ashlie;  Yang, Ronggui;  Srebric, Jelena;  Yin, Xiaobo;  Hu, Liangbing
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Structure and dynamics of the active human parathyroid hormone receptor-1 期刊论文
SCIENCE, 2019, 364 (6436) : 148-+
作者:  Zhao, Li-Hua;  Ma, Shanshan;  Sutkeviciute, Ieva;  Shen, Dan-Dan;  Zhou, X. Edward;  de Waal, Parker W.;  Li, Chen-Yao;  Kang, Yanyong;  Clark, Lisa J.;  Jean-Alphonse, Frederic G.;  White, Alex D.;  Yang, Dehua;  Dai, Antao;  Cai, Xiaoqing;  Chen, Jian;  Li, Cong;  Jiang, Yi;  Watanabe, Tomoyuki;  Gardella, Thomas J.;  Melcher, Karsten;  Wang, Ming-Wei;  Vilardaga, Jean-Pierre;  Xu, H. Eric;  Zhang, Yan
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Photocatalytic decarboxylative alkylations mediated by triphenylphosphine and sodium iodide 期刊论文
SCIENCE, 2019, 363 (6434) : 1429-+
作者:  Fu, Ming-Chen;  Shang, Rui;  Zhao, Bin;  Wang, Bing;  Fu, Yao
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Sheng, Chunjie;  Yao, Chen;  Wang, Ziyang;  Chen, Hongyuan;  Zhao, Yu;  Xu, Dazhi;  Huang, Haojie;  Huang, Wenlin;  Chen, Shuai
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27