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Atmospheric benzene measurements in the main metropolitan and industrial areas of Spain from 2014 to 2017 期刊论文
ATMOSPHERIC RESEARCH, 2020, 238
作者:  Notario, Alberto;  Gutierrez-Alvarez, Isidoro;  Antonio Adame, Jose
收藏  |  浏览/下载:8/0  |  提交时间:2020/08/18
Benzene  Air quality  Regional pollution  Local pollution  ERAS  ECMWF  
Ordinal regression algorithms for the analysis of convective situations over Madrid-Barajas airport 期刊论文
ATMOSPHERIC RESEARCH, 2020, 236
作者:  Guijo-Rubio, D.;  Casanova-Mateo, C.;  Sanz-Justo, J.;  Gutierrez, P. A.;  Cornejo-Bueno, S.;  Hervas, C.;  Salcedo-Sanz, S.
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Convective clouds  Convective analysis  Airports  Machine learning techniques  Ordinal regression  
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease 期刊论文
NATURE, 2020, 577 (7788) : 103-+
作者:  Lalaoui, Najoua;  Boyden, Steven E.;  Oda, Hirotsugu;  Wood, Geryl M.;  Stone, Deborah L.;  Chau, Diep;  Liu, Lin;  Stoffels, Monique;  Kratina, Tobias;  Lawlor, Kate E.;  Zaal, Kristien J. M.;  Hoffmann, Patrycja M.;  Etemadi, Nima;  Shield-Artin, Kristy;  Biben, Christine;  Tsai, Wanxia Li;  Blake, Mary D.;  Kuehn, Hye Sun;  Yang, Dan;  Anderton, Holly;  Silke, Natasha;  Wachsmuth, Laurens;  Zheng, Lixin;  Moura, Natalia Sampaio;  Beck, David B.;  Gutierrez-Cruz, Gustavo;  Ombrello, Amanda K.;  Pinto-Patarroyo, Gineth P.;  Kueh, Andrew J.;  Herold, Marco J.;  Hall, Cathrine;  Wang, Hongying;  Chae, Jae Jin;  Dmitrieva, Natalia I.;  McKenzie, Mark;  Light, Amanda;  Barham, Beverly K.;  Jones, Anne;  Romeo, Tina M.;  Zhou, Qing;  Aksentijevich, Ivona;  Mullikin, James C.;  Gross, Andrew J.;  Shum, Anthony K.;  Hawkins, Edwin D.;  Masters, Seth L.;  Lenardo, Michael J.;  Boehm, Manfred;  Rosenzweig, Sergio D.;  Pasparakis, Manolis;  Voss, Anne K.;  Gadina, Massimo;  Kastner, Daniel L.;  Silke, John
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term '  cleavage-resistant RIPK1-induced autoinflammatory syndrome'  . To define the mechanism for this disease, we generated a cleavage-resistant Ripk1(D325A) mutant mouse strain. Whereas Ripk1(-/-) mice died postnatally from systemic inflammation, Ripk1(D325A/D325A) mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1(D325A/D325A) and Ripk1(D325A/+) cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.


  
IRE1 alpha-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain 期刊论文
SCIENCE, 2019, 365 (6450) : 248-+
作者:  Chopra, Sahil;  Giovanelli, Paolo;  Alvarado-Vazquez, Perla Abigail;  Alonso, Sara;  Song, Minkyung;  Sandoval, Tito A.;  Chae, Chang-Suk;  Tan, Chen;  Fonseca, Miriam M.;  Gutierrez, Silvia;  Jimenez, Leandro;  Subbaramaiah, Kotha;  Iwawaki, Takao;  Kingsley, Philip J.;  Marnett, Lawrence J.;  Kossenkov, Andrew V.;  Crespo, Mariano Sanchez;  Dannenberg, Andrew J.;  Glimcher, Laurie H.;  Romero-Sandoval, E. Alfonso;  Cubillos-Ruiz, Juan R.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages 期刊论文
SCIENCE, 2019, 364 (6447) : 1279-+
作者:  Greenwood, Daniel J.;  Dos Santos, Mariana Silva;  Huang, Song;  Russell, Matthew R. G.;  Collinson, Lucy M.;  MacRae, James I.;  West, Andy;  Jiang, Haibo;  Gutierrez, Maximiliano G.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Probing magnetism in 2D materials at the nanoscale with single-spin microscopy 期刊论文
SCIENCE, 2019, 364 (6444) : 973-+
作者:  Thiel, L.;  Wang, Z.;  Tschudin, M. A.;  Rohner, D.;  Gutierrez-Lezama, I.;  Ubrig, N.;  Gibertini, M.;  Giannini, E.;  Morpurgo, A. F.;  Maletinsky, P.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Drive to help others 期刊论文
SCIENCE, 2019, 364 (6435) : 22-23
作者:  Gutierrez, Christopher
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
Bilobate comet morphology and internal structure controlled by shear deformation 期刊论文
NATURE GEOSCIENCE, 2019, 12 (3) : 157-+
作者:  Matonti, C.;  Attree, N.;  Groussin, O.;  Jorda, L.;  Viseur, S.;  Hviid, S. F.;  Bouley, S.;  Nebouy, D.;  Auger, A-T;  Lamy, P. L.;  Sierks, H.;  Naletto, G.;  Rodrigo, R.;  Koschny, D.;  Davidsson, B.;  Barucci, M. A.;  Bertaux, J-L;  Bertini, I;  Bodewits, D.;  Cremonese, G.;  Da Deppo, V;  Debei, S.;  De Cecco, M.;  Deller, J.;  Fornasier, S.;  Fulle, M.;  Gutierrez, P. J.;  Guettler, C.;  Ip, W-H;  Keller, H. U.;  Lara, L. M.;  La Forgia, F.;  Lazzarin, M.;  Lucchetti, A.;  Lopez-Moreno, J. J.;  Marzari, F.;  Massironi, M.;  Mottola, S.;  Oklay, N.;  Pajola, M.;  Penasa, L.;  Preusker, F.;  Rickman, H.;  Scholten, F.;  Shi, X.;  Toth, I;  Tubiana, C.;  Vincent, J-B
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/09
Prediction of low-visibility events due to fog using ordinal classification 期刊论文
ATMOSPHERIC RESEARCH, 2018, 214: 64-73
作者:  Guijo-Rubio, D.;  Gutierrez, P. A.;  Casanova-Mateo, C.;  Sanz-Justo, J.;  Salcedo-Sanz, S.;  Hervas-Martinez, C.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Airports  Fog events prediction  Time series  Forecasting  Ordinal classification  Time series preprocessing  
Secondary Ice Production by Fragmentation of Freezing Drops: Formulation and Theory 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2018, 75 (9) : 3031-3070
作者:  Phillips, Vaughan T. J.;  Patade, Sachin;  Gutierrez, Julie;  Bansemer, Aaron
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
Cloud microphysics  Clouds  Cumulus clouds  Clouds