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Flux Transfer Event Showers at Mercury: Dependence on Plasma β and Magnetic Shear and their Contribution to the Dungey Cycle 期刊论文
Geophysical Research Letters, 2020
作者:  W. J. Sun;  J. A. Slavin;  A. W. Smith;  R. M. Dewey;  G. K. Poh;  X. Jia;  J. M. Raines;  S. Livi;  Y. Saito;  D. J. Gershman;  G. A. DiBraccio;  S. M. Imber;  J. P. Guo;  S. Y. Fu;  Q. G. Zong;  J. T. Zhao
收藏  |  浏览/下载:14/0  |  提交时间:2020/10/20
Origin of Electron Boomerang Stripes: Localized ULF Wave‐particle Interactions 期刊论文
Geophysical Research Letters, 2020
作者:  X. X. Zhao;  Y. X. Hao;  Q. ‐;  G. Zong;  X. ‐;  Z. Zhou;  Chao Yue;  X. R. Chen;  Y. Liu;  J. B. Blake;  S. G. Claudepierre;  G. D. Reeves
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/14
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition 期刊论文
NATURE, 2020, 577 (7790) : 421-+
作者:  Xue, Jenny Y.;  Zhao, Yulei;  Aronowitz, Jordan;  Mai, Trang T.;  Vides, Alberto;  Qeriqi, Besnik;  Kim, Dongsung;  Li, Chuanchuan;  de Stanchina, Elisa;  Mazutis, Linas;  Risso, Davide;  Lito, Piro
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

KRAS GTPases are activated in one-third of cancers, and KRAS(G12C) is one of the most common activating alterations in lung adenocarcinoma(1,2). KRAS(G12C) inhibitors(3,4) are in phase-I clinical trials and early data show partial responses in nearly half of patients with lung cancer. How cancer cells bypass inhibition to prevent maximal response to therapy is not understood. Because KRAS(G12C) cycles between an active and inactive conformation(4-6), and the inhibitors bind only to the latter, we tested whether isogenic cell populations respond in a non-uniform manner by studying the effect of treatment at a single-cell resolution. Here we report that, shortly after treatment, some cancer cells are sequestered in a quiescent state with low KRAS activity, whereas others bypass this effect to resume proliferation. This rapid divergent response occurs because some quiescent cells produce new KRAS(G12C) in response to suppressed mitogen-activated protein kinase output. New KRAS(G12C) is maintained in its active, drug-insensitive state by epidermal growth factor receptor and aurora kinase signalling. Cells without these adaptive changes-or cells in which these changes are pharmacologically inhibited-remain sensitive to drug treatment, because new KRAS(G12C) is either not available or exists in its inactive, drug-sensitive state. The direct targeting of KRAS oncoproteins has been a longstanding objective in precision oncology. Our study uncovers a flexible non-uniform fitness mechanism that enables groups of cells within a population to rapidly bypass the effect of treatment. This adaptive process must be overcome if we are to achieve complete and durable responses in the clinic.


  
Simultaneous Observations of Localized and Global Drift Resonance 期刊论文
Geophysical Research Letters, 2020
作者:  Y. X. Hao;  X. X. Zhao;  Q. ‐;  G. Zong;  X. ‐;  Z. Zhou;  R. Rankin;  X. R. Chen;  Y. Liu;  S. Y. Fu;  J. B. Blake;  G. D. Reeves;  S. G. Claudepierre
收藏  |  浏览/下载:12/0  |  提交时间:2020/06/01
Evidence for Horizontal Blocking and Reflection of a Small-Scale Gravity Wave in the Mesosphere 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (10)
作者:  Criddle, N. R.;  Pautet, P-D;  Yuan, T.;  Heale, C.;  Snively, J.;  Zhao, Y.;  Taylor, M. J.
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/02
gravity wave  AMTM  Na lidar  mesosphere  wave blocking  
Late-spring frost risk between 1959 and 2017 decreased in North America but increased in Europe and Asia 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (22) : 12192-12200
作者:  Zohner, Constantin M.;  Mo, Lidong;  Renner, Susanne S.;  Svenning, Jens-Christian;  Vitasse, Yann;  Benito, Blas M.;  Ordonez, Alejandro;  Baumgarten, Frederik;  Bastin, Jean-Francois;  Sebald, Veronica;  Reich, Peter B.;  Liang, Jingjing;  Nabuurs, Gert-Jan;  de-Miguel, Sergio;  Alberti, Giorgio;  Anton-Fernandez, Clara;  Balazy, Radomir;  Braendli, Urs-Beat;  Chen, Han Y. H.;  Chisholm, Chelsea;  Cienciala, Emil;  Dayanandan, Selvadurai;  Fayle, Tom M.;  Frizzera, Lorenzo;  Gianelle, Damiano;  Jagodzinski, Andrzej M.;  Jaroszewicz, Bogdan;  Jucker, Tommaso;  Kepfer-Rojas, Sebastian;  Khan, Mohammed Latif;  Kim, Hyun Seok;  Korjus, Henn;  Johannsen, Vivian Kvist;  Laarmann, Diana;  Lang, Mait;  Zawila-Niedzwiecki, Tomasz;  Niklaus, Pascal A.;  Paquette, Alain;  Pretzsch, Hans;  Saikia, Purabi;  Schall, Peter;  Seben, Vladimir;  Svoboda, Miroslav;  Tikhonova, Elena;  Viana, Helder;  Zhang, Chunyu;  Zhao, Xiuhai;  Crowther, Thomas W.
收藏  |  浏览/下载:19/0  |  提交时间:2020/05/13
climate change  phenology  spring leaf-out  late frost  freezing damage  
Metabolic heterogeneity confers differences in melanoma metastatic potential 期刊论文
NATURE, 2020, 577 (7788) : 115-+
作者:  Tasdogan, Alpaslan;  Faubert, Brandon;  Ramesh, Vijayashree;  Ubellacker, Jessalyn M.;  Shen, Bo;  Solmonson, Ashley;  Murphy, Malea M.;  Gu, Zhimin;  Gu, Wen;  Martin, Misty;  Kasitinon, Stacy Y.;  Vandergriff, Travis;  Mathews, Thomas P.;  Zhao, Zhiyu;  Schadendorf, Dirk;  DeBerardinis, Ralph J.;  Morrison, Sean J.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

Metastasis requires cancer cells to undergo metabolic changes that are poorly understood(1-3). Here we show that metabolic differences among melanoma cells confer differences in metastatic potential as a result of differences in the function of the MCT1 transporter. In vivo isotope tracing analysis in patient-derived xenografts revealed differences in nutrient handling between efficiently and inefficiently metastasizing melanomas, with circulating lactate being a more prominent source of tumour lactate in efficient metastasizers. Efficient metastasizers had higher levels of MCT1, and inhibition of MCT1 reduced lactate uptake. MCT1 inhibition had little effect on the growth of primary subcutaneous tumours, but resulted in depletion of circulating melanoma cells and reduced the metastatic disease burden in patient-derived xenografts and in mouse melanomas. In addition, inhibition of MCT1 suppressed the oxidative pentose phosphate pathway and increased levels of reactive oxygen species. Antioxidants blocked the effects of MCT1 inhibition on metastasis. MCT1(high) and MCT1(-/low) cells from the same melanomas had similar capacities to form subcutaneous tumours, but MCT1(high) cells formed more metastases after intravenous injection. Metabolic differences among cancer cells thus confer differences in metastatic potential as metastasizing cells depend on MCT1 to manage oxidative stress.


  
The water lily genome and the early evolution of flowering plants 期刊论文
NATURE, 2020, 577 (7788) : 79-+
作者:  Zhang, Liangsheng;  Chen, Fei;  Zhang, Xingtan;  Li, Zhen;  Zhao, Yiyong;  Lohaus, Rolf;  Chang, Xiaojun;  Dong, Wei;  Ho, Simon Y. W.;  Liu, Xing;  Song, Aixia;  Chen, Junhao;  Guo, Wenlei;  Wang, Zhengjia;  Zhuang, Yingyu;  Wang, Haifeng;  Chen, Xuequn;  Hu, Juan;  Liu, Yanhui;  Qin, Yuan;  Wang, Kai;  Dong, Shanshan;  Liu, Yang;  Zhang, Shouzhou;  Yu, Xianxian;  Wu, Qian;  Wang, Liangsheng;  Yan, Xueqing;  Jiao, Yuannian;  Kong, Hongzhi;  Zhou, Xiaofan;  Yu, Cuiwei;  Chen, Yuchu;  Li, Fan;  Wang, Jihua;  Chen, Wei;  Chen, Xinlu;  Jia, Qidong;  Zhang, Chi;  Jiang, Yifan;  Zhang, Wanbo;  Liu, Guanhua;  Fu, Jianyu;  Chen, Feng;  Ma, Hong;  Van de Peer, Yves;  Tang, Haibao
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Water lilies belong to the angiosperm order Nymphaeales. Amborellales, Nymphaeales and Austrobaileyales together form the so-called ANA-grade of angiosperms, which are extant representatives of lineages that diverged the earliest from the lineage leading to the extant mesangiosperms(1-3). Here we report the 409-megabase genome sequence of the blue-petal water lily (Nymphaea colorata). Our phylogenomic analyses support Amborellales and Nymphaeales as successive sister lineages to all other extant angiosperms. The N. colorata genome and 19 other water lily transcriptomes reveal a Nymphaealean whole-genome duplication event, which is shared by Nymphaeaceae and possibly Cabombaceae. Among the genes retained from this whole-genome duplication are homologues of genes that regulate flowering transition and flower development. The broad expression of homologues of floral ABCE genes in N. colorata might support a similarly broadly active ancestral ABCE model of floral organ determination in early angiosperms. Water lilies have evolved attractive floral scents and colours, which are features shared with mesangiosperms, and we identified their putative biosynthetic genes in N. colorata. The chemical compounds and biosynthetic genes behind floral scents suggest that they have evolved in parallel to those in mesangiosperms. Because of its unique phylogenetic position, the N. colorata genome sheds light on the early evolution of angiosperms.


  
A New Theory for Energetic Electron Generation Behind Dipolarization Front 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (6)
作者:  Fu, H. S.;  Zhao, M. J.;  Yu, Y.;  Wang, Z.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
dipolarization front  energetic electrons  new theory  electron acceleration  magnetosonic wave  magnetic bottle  
Cluster Observations on Time-of-Flight Effect of Oxygen Ions in Magnetotail Reconnection Exhaust Region 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (3)
作者:  Wu, T.;  Fu, S. Y.;  Xie, L.;  Zong, Q-G;  Zhou, X. Z.;  Yue, C.;  Sun, W. J.;  Pu, Z. Y.;  Xiong, Y.;  Zhao, S. J.;  Zhang, H.;  Yu, F. B.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02