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A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Tao Su;  Robert A. Spicer;  Fei-Xiang Wu;  Alexander Farnsworth;  Jian Huang;  Cédric Del Rio;  Tao Deng;  Lin Ding;  Wei-Yu-Dong Deng;  Yong-Jiang Huang;  Alice Hughes;  Lin-Bo Jia;  Jian-Hua Jin;  Shu-Feng Li;  Shui-Qing Liang;  Jia Liu;  Xiao-Yan Liu;  Sarah Sherlock;  Teresa Spicer;  Gaurav Srivastava;  He Tang;  Paul Valdes;  Teng-Xiang Wang;  Mike Widdowson;  Meng-Xiao Wu;  Yao-Wu Xing;  Cong-Li Xu;  Jian Yang;  Cong Zhang;  Shi-Tao Zhang;  Xin-Wen Zhang;  Fan Zhao;  Zhe-Kun Zhou
收藏  |  浏览/下载:14/0  |  提交时间:2020/12/22
A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Tao Su;  Robert A. Spicer;  Fei-Xiang Wu;  Alexander Farnsworth;  Jian Huang;  Cédric Del Rio;  Tao Deng;  Lin Ding;  Wei-Yu-Dong Deng;  Yong-Jiang Huang;  Alice Hughes;  Lin-Bo Jia;  Jian-Hua Jin;  Shu-Feng Li;  Shui-Qing Liang;  Jia Liu;  Xiao-Yan Liu;  Sarah Sherlock;  Teresa Spicer;  Gaurav Srivastava;  He Tang;  Paul Valdes;  Teng-Xiang Wang;  Mike Widdowson;  Meng-Xiao Wu;  Yao-Wu Xing;  Cong-Li Xu;  Jian Yang;  Cong Zhang;  Shi-Tao Zhang;  Xin-Wen Zhang;  Fan Zhao;  Zhe-Kun Zhou
收藏  |  浏览/下载:12/0  |  提交时间:2020/12/22
A comprehensive quantification of global nitrous oxide sources and sinks 期刊论文
Nature, 2020
作者:  Hanqin Tian;  Rongting Xu;  Josep G. Canadell;  Rona L. Thompson;  Wilfried Winiwarter;  Parvadha Suntharalingam;  Eric A. Davidson;  Philippe Ciais;  Robert B. Jackson;  Greet Janssens-Maenhout;  Michael J. Prather;  Pierre Regnier;  Naiqing Pan;  Shufen Pan;  Glen P. Peters;  Hao Shi;  Francesco N. Tubiello;  ;  nke Zaehle;  Feng Zhou;  Almut Arneth;  Gianna Battaglia;  Sarah Berthet;  Laurent Bopp;  Alexander F. Bouwman;  Erik T. Buitenhuis;  Jinfeng Chang;  Martyn P. Chipperfield;  Shree R. S. Dangal;  Edward Dlugokencky;  James W. Elkins;  Bradley D. Eyre;  Bojie Fu;  Bradley Hall;  Akihiko Ito;  Fortunat Joos;  Paul B. Krummel;  Angela Landolfi;  Goulven G. Laruelle;  Ronny Lauerwald;  Wei Li;  Sebastian Lienert;  Taylor Maavara;  Michael MacLeod;  Dylan B. Millet;  Stefan Olin;  Prabir K. Patra;  Ronald G. Prinn;  Peter A. Raymond;  Daniel J. Ruiz;  Guido R. van der Werf;  Nicolas Vuichard;  Junjie Wang;  Ray F. Weiss;  Kelley C. Wells;  Chris Wilson;  Jia Yang;  Yuanzhi Yao
收藏  |  浏览/下载:25/0  |  提交时间:2020/10/12
Chemical‐Mechanical Impacts of CO2 Intrusion into Heterogeneous Caprock 期刊论文
Water Resources Research, 2020
作者:  Ting Xiao;  Hao Xu;  Nathan Moodie;  Richard Esser;  Wei Jia;  Liange Zheng;  Jonny Rutqvist;  Brian McPherson
收藏  |  浏览/下载:5/0  |  提交时间:2020/09/22
Asymmetric response of soil methane uptake rate to land degradation and restoration: Data synthesis 期刊论文
Global Change Biology, 2020
作者:  Junjun Wu;  Qiong Chen;  Wei Jia;  Chunyan Long;  Wenzhi Liu;  Guihua Liu;  Xiaoli Cheng
收藏  |  浏览/下载:9/0  |  提交时间:2020/09/14
Rapid increase in summer surface ozone over the North China Plain during 2013-2019: a side effect of particulate matters reduction control? 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Xiaodan Ma, Jianping Huang, Tianliang Zhao, Cheng Liu, Kaihui Zhao, Jia Xing, and Wei Xiao
收藏  |  浏览/下载:24/0  |  提交时间:2020/08/09
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
The water lily genome and the early evolution of flowering plants 期刊论文
NATURE, 2020, 577 (7788) : 79-+
作者:  Zhang, Liangsheng;  Chen, Fei;  Zhang, Xingtan;  Li, Zhen;  Zhao, Yiyong;  Lohaus, Rolf;  Chang, Xiaojun;  Dong, Wei;  Ho, Simon Y. W.;  Liu, Xing;  Song, Aixia;  Chen, Junhao;  Guo, Wenlei;  Wang, Zhengjia;  Zhuang, Yingyu;  Wang, Haifeng;  Chen, Xuequn;  Hu, Juan;  Liu, Yanhui;  Qin, Yuan;  Wang, Kai;  Dong, Shanshan;  Liu, Yang;  Zhang, Shouzhou;  Yu, Xianxian;  Wu, Qian;  Wang, Liangsheng;  Yan, Xueqing;  Jiao, Yuannian;  Kong, Hongzhi;  Zhou, Xiaofan;  Yu, Cuiwei;  Chen, Yuchu;  Li, Fan;  Wang, Jihua;  Chen, Wei;  Chen, Xinlu;  Jia, Qidong;  Zhang, Chi;  Jiang, Yifan;  Zhang, Wanbo;  Liu, Guanhua;  Fu, Jianyu;  Chen, Feng;  Ma, Hong;  Van de Peer, Yves;  Tang, Haibao
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Water lilies belong to the angiosperm order Nymphaeales. Amborellales, Nymphaeales and Austrobaileyales together form the so-called ANA-grade of angiosperms, which are extant representatives of lineages that diverged the earliest from the lineage leading to the extant mesangiosperms(1-3). Here we report the 409-megabase genome sequence of the blue-petal water lily (Nymphaea colorata). Our phylogenomic analyses support Amborellales and Nymphaeales as successive sister lineages to all other extant angiosperms. The N. colorata genome and 19 other water lily transcriptomes reveal a Nymphaealean whole-genome duplication event, which is shared by Nymphaeaceae and possibly Cabombaceae. Among the genes retained from this whole-genome duplication are homologues of genes that regulate flowering transition and flower development. The broad expression of homologues of floral ABCE genes in N. colorata might support a similarly broadly active ancestral ABCE model of floral organ determination in early angiosperms. Water lilies have evolved attractive floral scents and colours, which are features shared with mesangiosperms, and we identified their putative biosynthetic genes in N. colorata. The chemical compounds and biosynthetic genes behind floral scents suggest that they have evolved in parallel to those in mesangiosperms. Because of its unique phylogenetic position, the N. colorata genome sheds light on the early evolution of angiosperms.


  
CRISPR screen in regulatory T cells reveals modulators of Foxp3 期刊论文
NATURE, 2020
作者:  Xu, Daqian;  Wang, Zheng;  Xia, Yan;  Shao, Fei;  Xia, Weiya;  Wei, Yongkun;  Li, Xinjian;  Qian, Xu;  Lee, Jong-Ho;  Du, Linyong;  Zheng, Yanhua;  Lv, Guishuai;  Leu, Jia-shiun;  Wang, Hongyang;  Xing, Dongming;  Liang, Tingbo;  Hung, Mien-Chie;  Lu, Zhimin
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/03

Regulatory T (T-reg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumour immunity(1). Conversely, T-reg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties(2), can promote autoimmunity and/or facilitate more effective tumour immunity(3,4). A comprehensive understanding of the pathways that regulate Foxp3 could lead to more effective T-reg therapies for autoimmune disease and cancer. The availability of new functional genetic tools has enabled the possibility of systematic dissection of the gene regulatory programs that modulate Foxp3 expression. Here we developed a CRISPR-based pooled screening platform for phenotypes in primary mouse T-reg cells and applied this technology to perform a targeted loss-of-function screen of around 500 nuclear factors to identify gene regulatory programs that promote or disrupt Foxp3 expression. We identified several modulators of Foxp3 expression, including ubiquitin-specific peptidase 22 (Usp22) and ring finger protein 20 (Rnf20). Usp22, a member of the deubiquitination module of the SAGA chromatin-modifying complex, was revealed to be a positive regulator that stabilized Foxp3 expression  whereas the screen suggested that Rnf20, an E3 ubiquitin ligase, can serve as a negative regulator of Foxp3. T-reg-specific ablation of Usp22 in mice reduced Foxp3 protein levels and caused defects in their suppressive function that led to spontaneous autoimmunity but protected against tumour growth in multiple cancer models. Foxp3 destabilization in Usp22-deficient T-reg cells could be rescued by ablation of Rnf20, revealing a reciprocal ubiquitin switch in T-reg cells. These results reveal previously unknown modulators of Foxp3 and demonstrate a screening method that can be broadly applied to discover new targets for T-reg immunotherapies for cancer and autoimmune disease.


A CRISPR-based screening platform was used to identify previously uncharacterized genes that regulate the regulatory T cell-specific master transcription factor Foxp3, indicating that this screening method may be broadly applicable for the discovery of other genes involved in autoimmunity and immune responses to cancer.


  
Heat Wave Variations Across China Tied to Global SST Modes 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (6)
作者:  Wei, Jia;  Wang, Weiguang;  Shao, Quanxi;  Yu, Zhongbo;  Chen, Zefeng;  Huang, Yin;  Xing, Wanqiu
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Heatwave  ENSO  IOD  excess heat factor