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Evidence for intensification of meteorological droughts in Oman over the past four decades 期刊论文
Atmospheric Research, 2020
作者:  Ahmed M. El Kenawy, Ali Al Buloshi, Awadhi, Noura Al Nasiri, ... Sergio M. Vicente-Serrano
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/09
Evidence of non‐stationary relationships between climate and forest responses: Increased sensitivity to climate change in Iberian forests 期刊论文
Global Change Biology, 2020
作者:  Julen Astigarraga;  Enrique Andivia;  Miguel A. Zavala;  Antonio Gazol;  Veró;  nica Cruz‐;  Alonso;  Sergio M. Vicente‐;  Serrano;  Paloma Ruiz‐;  Benito
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/06
International evaluation of an AI system for breast cancer screening 期刊论文
NATURE, 2020, 577 (7788) : 89-+
作者:  McKinney, Scott Mayer;  Sieniek, Marcin;  Godbole, Varun;  Godwin, Jonathan;  Antropova, Natasha;  Ashrafian, Hutan;  Back, Trevor;  Chesus, Mary;  Corrado, Greg C.;  Darzi, Ara;  Etemadi, Mozziyar;  Garcia-Vicente, Florencia;  Gilbert, Fiona J.;  Halling-Brown, Mark;  Hassabis, Demis;  Jansen, Sunny;  Karthikesalingam, Alan;  Kelly, Christopher J.;  King, Dominic;  Ledsam, Joseph R.;  Melnick, David;  Mostofi, Hormuz;  Peng, Lily;  Reicher, Joshua Jay;  Romera-Paredes, Bernardino;  Sidebottom, Richard;  Suleyman, Mustafa;  Tse, Daniel;  Young, Kenneth C.;  De Fauw, Jeffrey;  Shetty, Shravya
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Screening mammography aims to identify breast cancer at earlier stages of the disease, when treatment can be more successful(1). Despite the existence of screening programmes worldwide, the interpretation of mammograms is affected by high rates of false positives and false negatives(2). Here we present an artificial intelligence (AI) system that is capable of surpassing human experts in breast cancer prediction. To assess its performance in the clinical setting, we curated a large representative dataset from the UK and a large enriched dataset from the USA. We show an absolute reduction of 5.7% and 1.2% (USA and UK) in false positives and 9.4% and 2.7% in false negatives. We provide evidence of the ability of the system to generalize from the UK to the USA. In an independent study of six radiologists, the AI system outperformed all of the human readers: the area under the receiver operating characteristic curve (AUC-ROC) for the AI system was greater than the AUC-ROC for the average radiologist by an absolute margin of 11.5%. We ran a simulation in which the AI system participated in the double-reading process that is used in the UK, and found that the AI system maintained non-inferior performance and reduced the workload of the second reader by 88%. This robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening.


  
De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
Science, 2020
作者:  Fabian Sesterhenn;  Che Yang;  Jaume Bonet;  Johannes T. Cramer;  Xiaolin Wen;  Yimeng Wang;  Chi-I Chiang;  Luciano A. Abriata;  Iga Kucharska;  Giacomo Castoro;  Sabrina S. Vollers;  Marie Galloux;  Elie Dheilly;  Stéphane Rosset;  Patricia Corthésy;  Sandrine Georgeon;  Mélanie Villard;  Charles-Adrien Richard;  Delphyne Descamps;  Teresa Delgado;  Elisa Oricchio;  Marie-Anne Rameix-Welti;  Vicente Más;  Sean Ervin;  Jean-François Eléouët;  Sabine Riffault;  John T. Bates;  Jean-Philippe Julien;  Yuxing Li;  Theodore Jardetzky;  Thomas Krey;  Bruno E. Correia
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/20
Changes in soil organic carbon under perennial crops 期刊论文
Global Change Biology, 2020
作者:  Alicia Ledo;  Pete Smith;  Ayalsew Zerihun;  Jeanette Whitaker;  José;  Luis Vicente‐;  Vicente;  Zhangcai Qin;  Niall P. McNamara;  Yuri L. Zinn;  Mireia Llorente;  Mark Liebig;  Matthias Kuhnert;  Marta Dondini;  Axel Don;  Eugenio Diaz‐;  Pines;  Ashim Datta;  Haakon Bakka;  Eduardo Aguilera;  Jon Hillier
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/20
Single-cell bacterial transcription measurements reveal the importance of dimethylsulfoniopropionate (DMSP) hotspots in ocean sulfur cycling 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Gao, Cherry;  Fernandez, Vicente I.;  Lee, Kang Soo;  Fenizia, Simona;  Pohnert, Georg;  Seymour, Justin R.;  Raina, Jean-Baptiste;  Stocker, Roman
收藏  |  浏览/下载:6/0  |  提交时间:2020/05/13
miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 (vol 512,pg 431, 2014) (Retraction of Vol 512, Pg 431, 2014) 期刊论文
NATURE, 2020
作者:  Noel, Paul;  Trier, Felix;  Vicente Arche, Luis M.;  Brehin, Julien;  Vaz, Diogo C.;  Garcia, Vincent;  Fusil, Stephane;  Barthelemy, Agnes;  Vila, Laurent;  Bibes, Manuel;  Attane, Jean-Philippe
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

A Retraction to this paper has been published and can be accessed via a link at the top of the paper.


  
Coupling of Indo-Pacific climate variability over the last millennium 期刊论文
NATURE, 2020
作者:  Chow, Brian W.;  Nunez, Vicente;  Kaplan, Luke;  Granger, Adam J.;  Bistrong, Karina;  Zucker, Hannah L.;  Kumar, Payal;  Sabatini, Bernardo L.;  Gu, Chenghua
收藏  |  浏览/下载:34/0  |  提交时间:2020/05/13

Coral records indicate that the variability of the Indian Ocean Dipole over the last millennium is strongly coupled to variability in the El Nino/Southern Oscillation and that recent extremes are unusual but not unprecedented.


The Indian Ocean Dipole (IOD) affects climate and rainfall across the world, and most severely in nations surrounding the Indian Ocean(1-4). The frequency and intensity of positive IOD events increased during the twentieth century(5) and may continue to intensify in a warming world(6). However, confidence in predictions of future IOD change is limited by known biases in IOD models(7) and the lack of information on natural IOD variability before anthropogenic climate change. Here we use precisely dated and highly resolved coral records from the eastern equatorial Indian Ocean, where the signature of IOD variability is strong and unambiguous, to produce a semi-continuous reconstruction of IOD variability that covers five centuries of the last millennium. Our reconstruction demonstrates that extreme positive IOD events were rare before 1960. However, the most extreme event on record (1997) is not unprecedented, because at least one event that was approximately 27 to 42 per cent larger occurred naturally during the seventeenth century. We further show that a persistent, tight coupling existed between the variability of the IOD and the El Nino/Southern Oscillation during the last millennium. Indo-Pacific coupling was characterized by weak interannual variability before approximately 1590, which probably altered teleconnection patterns, and by anomalously strong variability during the seventeenth century, which was associated with societal upheaval in tropical Asia. A tendency towards clustering of positive IOD events is evident in our reconstruction, which-together with the identification of extreme IOD variability and persistent tropical Indo-Pacific climate coupling-may have implications for improving seasonal and decadal predictions and managing the climate risks of future IOD variability.


  
The physical oceanography of the transport of floating marine debris 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (2)
作者:  van Sebille, Erik;  Aliani, Stefano;  Law, Kara Lavender;  Maximenko, Nikolai;  Alsina, Jose M.;  Bagaev, Andrei;  Bergmann, Melanie;  Chapron, Bertrand;  Chubarenko, Irina;  Cozar, Andres;  Delandmeter, Philippe;  Egger, Matthias;  Fox-Kemper, Baylor;  Garaba, Shungudzemwoyo P.;  Goddijn-Murphy, Lonneke;  Hardesty, Britta Denise;  Hoffman, Matthew J.;  Isobe, Atsuhiko;  Jongedijk, Cleo E.;  Kaandorp, Mikael L. A.;  Khatmullina, Liliya;  Koelmans, Albert A.;  Kukulka, Tobias;  Laufkotter, Charlotte;  Lebreton, Laurent;  Lobelle, Delphine;  Maes, Christophe;  Martinez-Vicente, Victor;  Maqueda, Miguel Angel Morales;  Poulain-Zarcos, Marie;  Rodriguez, Ernesto;  Ryan, Peter G.;  Shanks, Alan L.;  Shim, Won Joon;  Suaria, Giuseppe;  Thiel, Martin;  van den Bremer, Ton S.;  Wichmann, David
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/02
marine debris  physical oceanography  ocean circulation  remote sensing  fluid dynamics