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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
Science, 2020
作者:  Wanchao Yin;  Chunyou Mao;  Xiaodong Luan;  Dan-Dan Shen;  Qingya Shen;  Haixia Su;  Xiaoxi Wang;  Fulai Zhou;  Wenfeng Zhao;  Minqi Gao;  Shenghai Chang;  Yuan-Chao Xie;  Guanghui Tian;  He-Wei Jiang;  Sheng-Ce Tao;  Jingshan Shen;  Yi Jiang;  Hualiang Jiang;  Yechun Xu;  Shuyang Zhang;  Yan Zhang;  H. Eric Xu
收藏  |  浏览/下载：19/0  |  提交时间：2020/06/29
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Are Late Permian carbon isotope excursions of local or of global significance? 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (3-4) : 521-544
作者:  Bagherpour, Borhan;  Bucher, Hugo;  Vennemann, Torsten;  Schneebeli-Hermann, Elke;  Yuan, Dong-xun;  Leu, Marc;  Zhang, Chao;  Shen, Shu-Zhong
收藏  |  浏览/下载：8/0  |  提交时间：2020/07/02