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Strong hydroclimatic controls on vulnerability to subsurface nitrate contamination across Europe 期刊论文
Nature Communications, 2020
作者:  R. Kumar;  F. Heß;  e;  P. S. C. Rao;  A. Musolff;  J. W. Jawitz;  F. Sarrazin;  L. Samaniego;  J. H. Fleckenstein;  O. Rakovec;  S. Thober;  S. Attinger
收藏  |  浏览/下载：9/0  |  提交时间：2020/12/22
Observations of Electron Vortex at the Dipolarization Front 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Jiang, K.;  Huang, S. Y.;  Yuan, Z. G.;  Deng, X. H.;  Xu, S. B.;  Wei, Y. Y.;  He, L. H.;  Zhang, J.;  Zhang, Z. H.
收藏  |  浏览/下载：12/0  |  提交时间：2020/06/22
dipolarization front  electron vortex  small-scale plateau  asymmetric electric field  
Excitation of Whistler Waves Through the Bi‐directional Field‐Aligned Electron Beams with Electron Temperature Anisotropy: MMS Observations 期刊论文
Geophysical Research Letters, 2020
作者:  S. Y. Huang;  S. B. Xu;  L. H. He;  K. Jiang;  Z. G. Yuan;  X. H. Deng;  Y. Y. Wei;  J. Zhang;  Z. H. Zhang
收藏  |  浏览/下载：16/0  |  提交时间：2020/05/13
Implantation of Earth's Atmospheric Ions Into the Nearside and Farside Lunar Soil: Implications to Geodynamo Evolution 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (3)
作者:  Wei, Y.;  Zhong, J.;  Hui, H.;  Shi, Q.;  Cui, J.;  He, H.;  Zhang, H.;  Yao, Z.;  Yue, X.;  Rong, Z.;  He, F.;  Chai, L.;  Wan, W.
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/02
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).