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Late Miocene (10.0∼6.0 Ma) rapid exhumation of the Chinese South Tianshan: Implications for the timing of aridification in the Tarim Basin 期刊论文
Geophysical Research Letters, 2020
作者:  Jian Chang;  Stijn Glorie;  Nansheng Qiu;  Kyoungwon Min;  Yao Xiao;  Wei Xu
收藏  |  浏览/下载:11/0  |  提交时间:2021/01/22
Coherently forming a single molecule in an optical trap 期刊论文
Science, 2020
作者:  Xiaodong He;  Kunpeng Wang;  Jun Zhuang;  Peng Xu;  Xiang Gao;  Ruijun Guo;  Cheng Sheng;  Min Liu;  Jin Wang;  Jiaming Li;  G. V. Shlyapnikov;  Mingsheng Zhan
收藏  |  浏览/下载:18/0  |  提交时间:2020/10/20
Macroscopic somatic clonal expansion in morphologically normal human urothelium 期刊论文
Science, 2020
作者:  Ruoyan Li;  Yiqing Du;  Zhanghua Chen;  Deshu Xu;  Tianxin Lin;  Shanzhao Jin;  Gongwei Wang;  Ziyang Liu;  Min Lu;  Xu Chen;  Tao Xu;  Fan Bai
收藏  |  浏览/下载:8/0  |  提交时间:2020/10/12
Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons 期刊论文
Science, 2020
作者:  Wanling Peng;  Zhaofa Wu;  Kun Song;  Siyu Zhang;  Yulong Li;  Min Xu
收藏  |  浏览/下载:10/0  |  提交时间:2020/09/08
An orally available non-nucleotide STING agonist with antitumor activity 期刊论文
Science, 2020
作者:  Bo-Sheng Pan;  Samanthi A. Perera;  Jennifer A. Piesvaux;  Jeremy P. Presland;  Gottfried K. Schroeder;  Jared N. Cumming;  B. Wesley Trotter;  Michael D. Altman;  Alexei V. Buevich;  Brandon Cash;  Saso Cemerski;  Wonsuk Chang;  Yiping Chen;  Peter J. Dandliker;  Guo Feng;  Andrew Haidle;  Timothy Henderson;  James Jewell;  Ilona Kariv;  Ian Knemeyer;  Johnny Kopinja;  Brian M. Lacey;  Jason Laskey;  Charles A. Lesburg;  Rui Liang;  Brian J. Long;  Min Lu;  Yanhong Ma;  Ellen C. Minnihan;  Greg O’Donnell;  Ryan Otte;  Laura Price;  Larissa Rakhilina;  Berengere Sauvagnat;  Sharad Sharma;  Sriram Tyagarajan;  Hyun Woo;  Daniel F. Wyss;  Serena Xu;  David Jonathan Bennett;  George H. Addona
收藏  |  浏览/下载:13/0  |  提交时间:2020/08/25
Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat 期刊论文
Science, 2020
作者:  Hongwei Wang;  Silong Sun;  Wenyang Ge;  Lanfei Zhao;  Bingqian Hou;  Kai Wang;  Zhongfan Lyu;  Liyang Chen;  Shoushen Xu;  Jun Guo;  Min Li;  Peisen Su;  Xuefeng Li;  Guiping Wang;  Cunyao Bo;  Xiaojian Fang;  Wenwen Zhuang;  Xinxin Cheng;  Jianwen Wu;  Luhao Dong;  Wuying Chen;  Wen Li;  Guilian Xiao;  Jinxiao Zhao;  Yongchao Hao;  Ying Xu;  Yu Gao;  Wenjing Liu;  Yanhe Liu;  Huayan Yin;  Jiazhu Li;  Xiang Li;  Yan Zhao;  Xiaoqian Wang;  Fei Ni;  Xin Ma;  Anfei Li;  Steven S. Xu;  Guihua Bai;  Eviatar Nevo;  Caixia Gao;  Herbert Ohm;  Lingrang Kong
收藏  |  浏览/下载:15/0  |  提交时间:2020/05/25
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/03
Action of a minimal contractile bactericidal nanomachine 期刊论文
NATURE, 2020, 580 (7805) : 658-+
作者:  Peng, Ruchao;  Xu, Xin;  Jing, Jiamei;  Wang, Min;  Peng, Qi;  Liu, Sheng;  Wu, Ying;  Bao, Xichen;  Wang, Peiyi;  Qi, Jianxun;  Gao, George F.;  Shi, Yi
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

The authors report near-atomic resolution structures of the R-type bacteriocin from Pseudomonas aeruginosa in the pre-contraction and post-contraction states, and these structures provide insight into the mechanism of action of molecular syringes.


R-type bacteriocins are minimal contractile nanomachines that hold promise as precision antibiotics(1-4). Each bactericidal complex uses a collar to bridge a hollow tube with a contractile sheath loaded in a metastable state by a baseplate scaffold(1,2). Fine-tuning of such nucleic acid-free protein machines for precision medicine calls for an atomic description of the entire complex and contraction mechanism, which is not available from baseplate structures of the (DNA-containing) T4 bacteriophage(5). Here we report the atomic model of the complete R2 pyocin in its pre-contraction and post-contraction states, each containing 384 subunits of 11 unique atomic models of 10 gene products. Comparison of these structures suggests the following sequence of events during pyocin contraction: tail fibres trigger lateral dissociation of baseplate triplexes  the dissociation then initiates a cascade of events leading to sheath contraction  and this contraction converts chemical energy into mechanical force to drive the iron-tipped tube across the bacterial cell surface, killing the bacterium.