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Elevated atmospheric CO2 reduces yield‐scaled N2O fluxes from subtropical rice systems: Six site‐years field experiments 期刊论文
Global Change Biology, 2020
作者:  Zhisheng Yao;  Rui Wang;  Xunhua Zheng;  Baoling Mei;  Zaixing Zhou;  Baohua Xie;  Haibo Dong;  Chunyan Liu;  Shenghui Han;  Zhongjun Xu;  Klaus Butterbach‐;  Bahl;  Jianguo Zhu
收藏  |  浏览/下载:14/0  |  提交时间:2020/11/20
Near-real-time monitoring of global CO2 emissions reveals the effects of the COVID-19 pandemic 期刊论文
Nature Communications, 2020
作者:  Zhu Liu;  Philippe Ciais;  Zhu Deng;  Ruixue Lei;  Steven J. Davis;  Sha Feng;  Bo Zheng;  Duo Cui;  Xinyu Dou;  Biqing Zhu;  Rui Guo;  Piyu Ke;  Taochun Sun;  Chenxi Lu;  Pan He;  Yuan Wang;  Xu Yue;  Yilong Wang;  Yadong Lei;  Hao Zhou;  Zhaonan Cai;  Yuhui Wu;  Runtao Guo;  Tingxuan Han;  Jinjun Xue;  Olivier Boucher;  Eulalie Boucher;  Fré;  ;  ric Chevallier;  Katsumasa Tanaka;  Yimin Wei;  Haiwang Zhong;  Chongqing Kang;  Ning Zhang;  Bin Chen;  Fengming Xi;  Miaomiao Liu;  Franç;  ois-Marie Bré;  on;  Yonglong Lu;  Qiang Zhang;  Dabo Guan;  Peng Gong;  Daniel M. Kammen;  Kebin He;  Hans Joachim Schellnhuber
收藏  |  浏览/下载:18/0  |  提交时间:2020/10/20
Long‐term active restoration of extremely degraded alpine grassland accelerated turnover and increased stability of soil carbon 期刊论文
Global Change Biology, 2020
作者:  Yanfu Bai;  Lina Ma;  Abraham A. Degen;  Muhammad K. Rafiq;  Yakov Kuzyakov;  Jingxue Zhao;  Rui Zhang;  Tao Zhang;  Wenyin Wang;  Xiaogang Li;  Ruijun Long;  Zhanhuan Shang
收藏  |  浏览/下载:7/0  |  提交时间:2020/10/20
Black phosphorus composites with engineered interfaces for high-rate high-capacity lithium storage 期刊论文
Science, 2020
作者:  Hongchang Jin;  Sen Xin;  Chenghao Chuang;  Wangda Li;  Haiyun Wang;  Jian Zhu;  Huanyu Xie;  Taiming Zhang;  Yangyang Wan;  Zhikai Qi;  Wensheng Yan;  Ying-Rui Lu;  Ting-Shan Chan;  Xiaojun Wu;  John B. Goodenough;  Hengxing Ji;  Xiangfeng Duan
收藏  |  浏览/下载:15/0  |  提交时间:2020/10/12
Light grazing facilitates carbon accumulation in subsoil in Chinese grasslands: A meta‐analysis 期刊论文
Global Change Biology, 2020
作者:  Zhi‐;  Yun Jiang;  Zhong‐;  Min Hu;  Derrick Y. F. Lai;  Dao‐;  Rui Han;  Mei Wang;  Min Liu;  Meng Zhang;  Ming‐;  Yan Guo
收藏  |  浏览/下载:8/0  |  提交时间:2020/10/12
SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation 期刊论文
Science, 2020
作者:  Xin Wu;  Yun Wang;  Rui Huang;  Qujing Gai;  Haofei Liu;  Meimei Shi;  Xiang Zhang;  Yonglin Zuo;  Longjuan Chen;  Qiwen Zhao;  Yu Shi;  Fengchao Wang;  Xiaowei Yan;  Huiping Lu;  Senlin Xu;  Xiaohong Yao;  Lin Chen;  Xia Zhang;  Qiang Tian;  Ziyan Yang;  Bo Zhong;  Chen Dong;  Yan Wang;  Xiu-Wu Bian;  Xindong Liu
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/25
Covalent surface modifications and superconductivity of two-dimensional metal carbide MXenes 期刊论文
Science, 2020
作者:  Vladislav Kamysbayev;  Alexander S. Filatov;  Huicheng Hu;  Xue Rui;  Francisco Lagunas;  Di Wang;  Robert F. Klie;  Dmitri V. Talapin
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/25
Aggregating data from COVID-19 trials 期刊论文
Science, 2020
作者:  Elizabeth L. Ogburn;  Barbara E. Bierer;  Ron Brookmeyer;  Christine Choirat;  Natalie E. Dean;  Victor De Gruttola;  Susan S. Ellenberg;  M. Elizabeth Halloran;  Daniel F. Hanley;  Joseph K. Lee;  Rui Wang;  Daniel O. Scharfstein
收藏  |  浏览/下载:5/0  |  提交时间:2020/06/16
Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Lu, Dawei;  Luo, Qian;  Chen, Rui;  Zhuansun, Yongxun;  Jiang, Jie;  Wang, Weichao;  Yang, Xuezhi;  Zhang, Luyao;  Liu, Xiaolei;  Li, Fang;  Liu, Qian;  Jiang, Guibin
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/25
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:43/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.