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Enhanced growth rate of atmospheric particles from sulfuric acid 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7359-7372
作者:  Stolzenburg, Dominik;  Simon, Mario;  Ranjithkumar, Ananth;  Kuerten, Andreas;  Lehtipalo, Katrianne;  Gordon, Hamish;  Ehrhart, Sebastian;  Finkenzeller, Henning;  Pichelstorfer, Lukas;  Nieminen, Tuomo;  He, Xu-Cheng;  Brilke, Sophia;  Xiao, Mao;  Amorim, Antonio;  Baalbaki, Rima;  Baccarini, Andrea;  Beck, Lisa;  Brakling, Steffen;  Murillo, Lucia Caudillo;  Chen, Dexian;  Chu, Biwu;  Dada, Lubna;  Dias, Antonio;  Dommen, Josef;  Duplissy, Jonathan;  El Haddad, Imad;  Fischer, Lukas;  Carracedo, Loic Gonzalez;  Heinritzi, Martin;  Kim, Changhyuk;  Koenig, Theodore K.;  Kong, Weimeng;  Lamkaddam, Houssni;  Lee, Chuan Ping;  Leiminger, Markus;  Li, Zijun;  Makhmutov, Vladimir;  Manninen, Hanna E.;  Marie, Guillaume;  Marten, Ruby;  Mueller, Tatjana;  Nie, Wei;  Partoll, Eva;  Petaja, Tuukka;  Pfeifer, Joschka;  Philippov, Maxim;  Rissanen, Matti P.;  Rorup, Birte;  Schobesberger, Siegfried;  Schuchmann, Simone;  Shen, Jiali;  Sipila, Mikko;  Steiner, Gerhard;  Stozhkov, Yuri;  Tauber, Christian;  Tham, Yee Jun;  Tome, Antonio;  Vazquez-Pufleau, Miguel;  Wagner, Andrea C.;  Wang, Mingyi;  Wang, Yonghong;  Weber, Stefan K.;  Wimmer, Daniela;  Wlasits, Peter J.;  Wu, Yusheng;  Ye, Qing;  Zauner-Wieczorek, Marcel;  Baltensperger, Urs;  Carslaw, Kenneth S.;  Curtius, Joachim;  Donahue, Neil M.;  Flagan, Richard C.;  Hansel, Armin;  Kulmala, Markku;  Lelieveld, Jos;  Volkamer, Rainer;  Kirkby, Jasper;  Winkler, Paul M.
收藏  |  浏览/下载：25/0  |  提交时间：2020/08/18
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).