GSTDTAP

浏览/检索结果: 共4条,第1-4条 帮助

限定条件        
已选(0)清除 条数/页:   排序方式:
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms 期刊论文
NATURE, 2020, 579 (7800) : 603-+
作者:  Xu, Wanghuai;  Zheng, Huanxi;  Liu, Yuan;  Zhou, Xiaofeng;  Zhang, Chao;  Song, Yuxin;  Deng, Xu;  Leung, Michael;  Yang, Zhengbao;  Xu, Ronald X.;  Wang, Zhong Lin;  Zeng, Xiao Cheng;  Wang, Zuankai
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/03

Acetaldehyde is a highly reactive, DNA-damaging metabolite that is produced upon alcohol consumption(1). Impaired detoxification of acetaldehyde is common in the Asian population, and is associated with alcohol-related cancers(1,2). Cells are protected against acetaldehyde-induced damage by DNA crosslink repair, which when impaired causes Fanconi anaemia (FA), a disease resulting in failure to produce blood cells and a predisposition to cancer(3,4). The combined inactivation of acetaldehyde detoxification and the FA pathway induces mutation, accelerates malignancies and causes the rapid attrition of blood stem cells(5-7). However, the nature of the DNA damage induced by acetaldehyde and how this is repaired remains a key question. Here we generate acetaldehyde-induced DNA interstrand crosslinks and determine their repair mechanism in Xenopus egg extracts. We find that two replication-coupled pathways repair these lesions. The first is the FA pathway, which operates using excision-analogous to the mechanism used to repair the interstrand crosslinks caused by the chemotherapeutic agent cisplatin. However, the repair of acetaldehyde-induced crosslinks results in increased mutation frequency and an altered mutational spectrum compared with the repair of cisplatin-induced crosslinks. The second repair mechanism requires replication fork convergence, but does not involve DNA incisions-instead the acetaldehyde crosslink itself is broken. The Y-family DNA polymerase REV1 completes repair of the crosslink, culminating in a distinct mutational spectrum. These results define the repair pathways of DNA interstrand crosslinks caused by an endogenous and alcohol-derived metabolite, and identify an excision-independent mechanism.


DNA interstrand crosslinks induced by acetaldehyde are repaired by both the Fanconi anaemia pathway and by a second, excision-independent repair mechanism.


  
Abandonment lead to structural degradation and changes in carbon allocation patterns in Moso bamboo forests 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 449
作者:  Yin, Jiayang;  Ge, Zhipeng;  Deng, Xu;  Shi, Yongjun;  Xu, Lin;  Zhou, Guomo;  Ye, Yuzhu;  Zhang, Fagen;  Zhou, Yufeng;  Li, Chong;  Niu, Zhengwen
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Phyllostachys pubescens  Structure degradation  Carbon allocation pattern  Abandoned bamboo forests  
Quantifying driving factors of vegetation carbon stocks of Moso bamboo forests using machine learning algorithm combined with structural equation model 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 429: 406-413
作者:  Shi, Yongjun;  Xu, Lin;  Zhou, Yufeng;  Ji, Biyong;  Zhou, Guomo;  Fang, Huiyun;  Yin, Jiayang;  Deng, Xu
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
Vegetation carbon stocks  Carbon sequestration  Driving factors  Machine learning method  Structural equation modeling  Phyllostachys pubescens  
Reconfiguring surface functions using visible-light- controlled metal-ligand coordination 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Xie, Chaoming;  Sun, Wen;  Lu, Hao;  Kretzschmann, Annika;  Liu, Jiahui;  Wagner, Manfred;  Butt, Hans-Juergen;  Deng, Xu;  Wu, Si
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27