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WHY HEALTHY ARTERIES MIGHT HELP KIDS AVOID COVID COMPLICATIONS 期刊论文
NATURE, 2020, 582 (7812) : 324-325
作者:  Niu, Jixiao;  Sun, Yang;  Chen, Baoen;  Zheng, Baohui;  Jarugumilli, Gopala K.;  Walker, Sarah R.;  Hata, Aaron N.;  Mino-Kenudson, Mari;  Frank, David A.;  Wu, Xu
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03
SCIENCE FUNDING FACES POST-PANDEMIC UPHEAVALS 期刊论文
NATURE, 2020, 582 (7811) : 164-165
作者:  Mueller, Johannes B.;  Geyer, Philipp E.;  Colaco, Ana R.;  Treit, Peter, V;  Strauss, Maximilian T.;  Oroshi, Mario;  Doll, Sophia;  Winter, Sebastian Virreira;  Bader, Jakob M.;  Koehler, Niklas;  Theis, Fabian;  Santos, Alberto;  Mann, Matthias
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/03
Australian junior scientists report damaging lack of support at work 期刊论文
NATURE, 2020, 579 (7799) : 457-458
作者:  Aveline, David C.;  Williams, Jason R.;  Elliott, Ethan R.;  Dutenhoffer, Chelsea;  Kellogg, James R.;  Kohel, James M.;  Lay, Norman E.;  Oudrhiri, Kamal;  Shotwell, Robert F.;  Yu, Nan;  Thompson, Robert J.
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/03
CORONAVIRUS TESTS GO UNUSED IN THEIR THOUSANDS 期刊论文
NATURE, 2020, 580 (7803) : 312-313
作者:  Slabicki, Mikolaj;  Kozicka, Zuzanna;  Petzold, Georg;  Li, Yen-Der;  Manojkumar, Manisha;  Bunker, Richard D.;  Donovan, Katherine A.;  Sievers, Quinlan L.;  Koeppel, Jonas;  Suchyta, Dakota;  Sperling, Adam S.;  Fink, Emma C.;  Gasser, Jessica A.;  Wang, Li R.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03
HACKS TO HELP RESEARCHERS PUT WORDS ON THE PAGE 期刊论文
NATURE, 2020, 580 (7801) : 151-153
作者:  Lee, Jiyoon;  Rabbani, Cyrus C.;  Gao, Hongyu;  Steinhart, Matthew R.;  Woodruff, Benjamin M.;  Pflum, Zachary E.;  Kim, Alexander;  Heller, Stefan;  Liu, Yunlong;  Shipchandler, Taha Z.;  Koehler, Karl R.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

Productivity coaches, boot camps and online meet-ups teach researchers to avoid distractions and negative thoughts to get their writing projects done.


Productivity coaches, boot camps and online meet-ups teach researchers to avoid distractions and negative thoughts to get their writing projects done.


  
Nearest neighbours reveal fast and slow components of motor learning 期刊论文
NATURE, 2020, 577 (7791) : 526-+
作者:  Kollmorgen, Sepp;  Hahnloser, Richard H. R.;  Mante, Valerio
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/03

A new method for analysing change in high-dimensional data is based on nearest-neighbour statistics and is applied here to song dynamics during vocal learning in zebra finches, but could potentially be applied to other biological and artificial behaviours.


Changes in behaviour resulting from environmental influences, development and learning(1-5) are commonly quantified on the basis of a few hand-picked features(2-4,6,7) (for example, the average pitch of acoustic vocalizations(3)), assuming discrete classes of behaviours (such as distinct vocal syllables)(2,3,8-10). However, such methods generalize poorly across different behaviours and model systems and may miss important components of change. Here we present a more-general account of behavioural change that is based on nearest-neighbour statistics(11-13), and apply it to song development in a songbird, the zebra finch(3). First, we introduce the concept of '  repertoire dating'  , whereby each rendition of a behaviour (for example, each vocalization) is assigned a repertoire time, reflecting when similar renditions were typical in the behavioural repertoire. Repertoire time isolates the components of vocal variability that are congruent with long-term changes due to vocal learning and development, and stratifies the behavioural repertoire into '  regressions'  , '  anticipations'  and '  typical renditions'  . Second, we obtain a holistic, yet low-dimensional, description of vocal change in terms of a stratified '  behavioural trajectory'  , revealing numerous previously unrecognized components of behavioural change on fast and slow timescales, as well as distinct patterns of overnight consolidation(1,2,4,14,15) across the behavioral repertoire. We find that diurnal changes in regressions undergo only weak consolidation, whereas anticipations and typical renditions consolidate fully. Because of its generality, our nonparametric description of how behaviour evolves relative to itself-rather than to a potentially arbitrary, experimenter-defined goal(2,3,14,16)-appears well suited for comparing learning and change across behaviours and species(17,18), as well as biological and artificial systems(5).


  
International evaluation of an AI system for breast cancer screening 期刊论文
NATURE, 2020, 577 (7788) : 89-+
作者:  McKinney, Scott Mayer;  Sieniek, Marcin;  Godbole, Varun;  Godwin, Jonathan;  Antropova, Natasha;  Ashrafian, Hutan;  Back, Trevor;  Chesus, Mary;  Corrado, Greg C.;  Darzi, Ara;  Etemadi, Mozziyar;  Garcia-Vicente, Florencia;  Gilbert, Fiona J.;  Halling-Brown, Mark;  Hassabis, Demis;  Jansen, Sunny;  Karthikesalingam, Alan;  Kelly, Christopher J.;  King, Dominic;  Ledsam, Joseph R.;  Melnick, David;  Mostofi, Hormuz;  Peng, Lily;  Reicher, Joshua Jay;  Romera-Paredes, Bernardino;  Sidebottom, Richard;  Suleyman, Mustafa;  Tse, Daniel;  Young, Kenneth C.;  De Fauw, Jeffrey;  Shetty, Shravya
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Screening mammography aims to identify breast cancer at earlier stages of the disease, when treatment can be more successful(1). Despite the existence of screening programmes worldwide, the interpretation of mammograms is affected by high rates of false positives and false negatives(2). Here we present an artificial intelligence (AI) system that is capable of surpassing human experts in breast cancer prediction. To assess its performance in the clinical setting, we curated a large representative dataset from the UK and a large enriched dataset from the USA. We show an absolute reduction of 5.7% and 1.2% (USA and UK) in false positives and 9.4% and 2.7% in false negatives. We provide evidence of the ability of the system to generalize from the UK to the USA. In an independent study of six radiologists, the AI system outperformed all of the human readers: the area under the receiver operating characteristic curve (AUC-ROC) for the AI system was greater than the AUC-ROC for the average radiologist by an absolute margin of 11.5%. We ran a simulation in which the AI system participated in the double-reading process that is used in the UK, and found that the AI system maintained non-inferior performance and reduced the workload of the second reader by 88%. This robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening.


  
Transparent ferroelectric crystals with ultrahigh piezoelectricity 期刊论文
NATURE, 2020, 577 (7790) : 350-+
作者:  Qiu, Chaorui;  Wang, Bo;  Zhang, Nan;  Zhang, Shujun;  Liu, Jinfeng;  Walker, David;  Wang, Yu;  Tian, Hao;  Shrout, Thomas R.;  Xu, Zhuo;  Chen, Long-Qing;  Li, Fei
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Transparent piezoelectrics are highly desirable for numerous hybrid ultrasound-optical devices ranging from photoacoustic imaging transducers to transparent actuators for haptic applications(1-7). However, it is challenging to achieve high piezoelectricity and perfect transparency simultaneously because most high-performance piezoelectrics are ferroelectrics that contain high-density light-scattering domain walls. Here, through a combination of phase-field simulations and experiments, we demonstrate a relatively simple method of using an alternating-current electric field to engineer the domain structures of originally opaque rhombohedral Pb(Mg1/3Nb2/3)O-3-PbTiO3 (PMN-PT) crystals to simultaneously generate near-perfect transparency, an ultrahigh piezoelectric coefficient d(33) (greater than 2,100 picocoulombs per newton), an excellent electromechanical coupling factor k(33) (about 94 per cent) and a large electro-optical coefficient gamma(33) (approximately 220 picometres per volt), which is far beyond the performance of the commonly used transparent ferroelectric crystal LiNbO3. We find that increasing the domain size leads to a higher d(33) value for the [001]-oriented rhombohedral PMN-PT crystals, challenging the conventional wisdom that decreasing the domain size always results in higher piezoelectricity(8-10). This work presents a paradigm for achieving high transparency and piezoelectricity by ferroelectric domain engineering, and we expect the transparent ferroelectric crystals reported here to provide a route to a wide range of hybrid device applications, such as medical imaging, self-energy-harvesting touch screens and invisible robotic devices.


  
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Turning connective tissue into neurons for 10 years 期刊论文
NATURE, 2020, 578 (7796) : 522-524
作者:  Acquaviva, Laurent;  Boekhout, Michiel;  Karasu, Mehmet E.;  Brick, Kevin;  Pratto, Florencia;  Li, Tao;  van Overbeek, Megan;  Kauppi, Liisa;  Camerini-Otero, R. Daniel;  Jasin, Maria;  Keeney, Scott
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

An historic breakthrough that altered our understanding of cell fate.


A method for directly converting connective-tissue cells into neurons opened up a new branch of research into cell-based therapies and called into question long-held beliefs about how development affects a cell'  s identity.