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Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Palaeoarchaean deep mantle heterogeneity recorded by enriched plume remnants 期刊论文
NATURE GEOSCIENCE, 2019, 12 (8) : 672-678
作者:  Wang, Chao;  Song, Shuguang;  Wei, Chunjing;  Su, Li;  Allen, Mark B.;  Niu, Yaoling;  Li, Xian-Hua;  Dong, Jinlong
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Obligate to facultative shift of two epiphytic Lepisorus species during subtropical forest degradation: Insights from functional traits 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 435: 66-76
作者:  Chen, Quan;  Lu, Hua-Zheng;  Liu, Wen-Yao;  Wu, Yi;  Song, Liang;  Li, Su
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
Epiphytic fern  Forest degradation  Functional traits  Facultative  Obligate  Plasticity  
Impact of atmospheric model resolution on simulation of ENSO feedback processes: a coupled model study 期刊论文
CLIMATE DYNAMICS, 2018, 51: 3077-3092
作者:  Hua, Lijuan;  Chen, Lin;  Rong, Xinyao;  Su, Jingzhi;  Wang, Lu;  Li, Tim;  Yu, Yongqiang
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
ENSO  BJ index  Air-sea feedback  CGCM  Model resolution  
Single-crystal x-ray diffraction structures of covalent organic frameworks 期刊论文
SCIENCE, 2018, 361 (6397) : 48-52
作者:  Ma, Tianqiong;  Kapustin, Eugene A.;  Yin, Shawn X.;  Liang, Lin;  Zhou, Zhengyang;  Niu, Jing;  Li, Li-Hua;  Wang, Yingying;  Su, Jie;  Li, Jian;  Wang, Xiaoge;  Wang, Wei David;  Wang, Wei;  Sun, Junliang;  Yaghi, Omar M.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Why was the western Pacific subtropical anticyclone weaker in late summer after the 2015/2016 super El Nino? 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38 (1) : 55-65
作者:  Liu, Boqi;  Zhu, Congwen;  Su, Jingzhi;  Hua, Lijuan;  Duan, Yihong
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
the 2015  2016 super El Nino event  western Pacific subtropical anticyclone  cold SSTAs in western tropical Indian Ocean  air-sea interaction  
Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2017, 125 (5)
作者:  Liu, Chao-Bin;  Hong, Xin-Ru;  Shi, Miao;  Chen, Xiao-Qiu;  Huang, Hui-Juan;  Chen, Jin-Hua;  Yang, Kai;  Chen, Su-Qing;  Chen, Han-Qiang;  Kan, Hai-Dong;  Sun, Qing-Hua
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
On the Spatial Gradient of Soil Moisture-Precipitation Feedback Strength in the April 2011 Drought in the Southern Great Plains 期刊论文
JOURNAL OF CLIMATE, 2017, 30 (3)
作者:  Su, Hua;  Dickinson, Robert E.
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09