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Strong anthropogenic control of secondary organic aerosol formation from isoprene in Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7531-7552
作者:  Bryant, Daniel J.;  Dixon, William J.;  Hopkins, James R.;  Dunmore, Rachel E.;  Pereira, Kelly;  Shaw, Marvin;  Squires, Freya A.;  Bannan, Thomas J.;  Mehra, Archit;  Worrall, Stephen D.;  Bacak, Asan;  Coe, Hugh;  Percival, Carl J.;  Whalley, Lisa K.;  Heard, Dwayne E.;  Slater, Eloise J.;  Ouyang, Bin;  Cui, Tianqu;  Surratt, Jason D.;  Liu, Di;  Shi, Zongbo;  Harrison, Roy;  Sun, Yele;  Xu, Weiqi;  Lewis, Alastair C.;  Lee, James D.;  Rickard, Andrew R.;  Hamilton, Jacqueline F.
收藏  |  浏览/下载：15/0  |  提交时间：2020/08/18
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Physical Controls on Salmon Redd Site Selection in Restored Reaches of a Regulated, Gravel-Bed River 期刊论文
WATER RESOURCES RESEARCH, 2019
作者:  Harrison, Lee R.;  Bray, Erin;  Overstreet, Brandon;  Legleiter, Carl J.;  Brown, Rocko A.;  Merz, Joseph E.;  Bond, Rosealea M.;  Nicol, Colin L.;  Dunne, Thomas
收藏  |  浏览/下载：7/0  |  提交时间：2020/02/16
river restoration  salmonid spawning  fluvial geomorphology  hyporheic exchange  sediment transport  
Translating Marine Animal Tracking Data into Conservation Policy and Management 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2019, 34 (5) : 459-473
作者:  Hays, Graeme C.;  Bailey, Helen;  Bograd, Steven J.;  Bowen, W. Don;  Campagna, Claudio;  Carmichael, Ruth H.;  Casale, Paolo;  Chiaradia, Andre;  Costa, Daniel P.;  Cuevas, Eduardo;  de Bruyn, P. J. Nico;  Dias, Maria P.;  Duarte, Carlos M.;  Dunn, Daniel C.;  Dutton, Peter H.;  Esteban, Nicole;  Friedlaender, Ari;  Goetz, Kimberly T.;  Godley, Brendan J.;  Halpin, Patrick N.;  Hamann, Mark;  Hammerschlag, Neil;  Harcourt, Robert;  Harrison, Autumn-Lynn;  Hazen, Elliott L.;  Heupel, Michelle R.;  Hoyt, Erich;  Humphries, Nicolas E.;  Kot, Connie Y.;  Lea, James S. E.;  Marsh, Helene;  Maxwell, Sara M.;  McMahon, Clive R.;  di Sciara, Giuseppe Notarbartolo;  Palacios, Daniel M.;  Phillips, Richard A.;  Righton, David;  Schofield, Gail;  Seminoff, Jeffrey A.;  Simpfendorfer, Colin A.;  Sims, David W.;  Takahashi, Akinori;  Tetley, Michael J.;  Thums, Michele;  Trathan, Philip N.;  Villegas-Amtmann, Stella;  Wells, Randall S.;  Whiting, Scott D.;  Wildermann, Natalie E.;  Msequeira, Ana M. M.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/26
Meteorological Source Variability in Atmospheric Gravity Wave Parameters Derived From a Tropical Infrasound Station 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (8) : 4352-4364
作者:  Marlton, G. J.;  Charlton-Perez, A. J.;  Harrison, R. G.;  Blanc, E.;  Evers, L.;  Le-Pichon, A.;  Smets, P. S. M.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/26
Secondary magnetite in ancient zircon precludes analysis of a Hadean geodynamo 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (2) : 407-412
作者:  Tang, Fengzai;  Taylor, Richard J. M.;  Einsle, Josh F.;  Borlina, Caue S.;  Fu, Roger R.;  Weiss, Benjamin P.;  Williams, Helen M.;  Williams, Wyn;  Nagy, Lesleis;  Midgley, Paul A.;  Lima, Eduardo A.;  Bell, Elizabeth A.;  Harrison, T. Mark;  Alexander, Ellen W.;  Harrison, Richard J.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Hadean  paleomagnetism  Jack Hills  zircon  correlative microscopy  
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder 期刊论文
SCIENCE, 2018, 362 (6420) : 1270-+
作者:  An, Joon-Yong;  Lin, Kevin;  Zhu, Lingxue;  Werling, Donna M.;  Dong, Shan;  Brand, Harrison;  Wang, Harold Z.;  Zhao, Xuefang;  Schwartz, Grace B.;  Collins, Ryan L.;  Currall, Benjamin B.;  Dastmalchi, Claudia;  Dea, Jeanselle;  Duhn, Clif;  Gilson, Michael C.;  Klei, Lambertus;  Liang, Lindsay;  Markenscoff-Papadimitriou, Eirene;  Pochareddy, Sirisha;  Ahituv, Nadav;  Buxbaum, Joseph D.;  Coon, Hilary;  Daly, Mark J.;  Kim, Young Shin;  Marth, Gabor T.;  Neale, Benjamin M.;  Quinlan, Aaron R.;  Rubenstein, John L.;  Sestan, Nenad;  State, Matthew W.;  Willsey, A. Jeremy;  Talkowski, Michael E.;  Devlin, Bernie;  Roeder, Kathryn;  Sanders, Stephan J.
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
Saharan dust plume charging observed over the UK (vol 13, 054018, 2018) 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (10)
作者:  Harrison, R. Giles;  Nicoll, Keri A.;  Marlton, Graeme J.;  Ryder, Claire L.;  Bennett, Alec J.
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09
Saharan dust plume charging observed over the UK 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (5)
作者:  Harrison, R. Giles;  Nicoll, Keri A.;  Marlton, Graeme J.;  Ryder, Claire L.;  Bennett, Alec J.
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
dust  meteorology  electrostatics  
Electrical sensing of the dynamical structure of the planetary boundary layer 期刊论文
ATMOSPHERIC RESEARCH, 2018, 202: 81-95
作者:  Nicoll, K. A.;  Harrison, R. G.;  Silva, H. G.;  Salgado, R.;  Melgao, M.;  Bortoli, D.
收藏  |  浏览/下载：0/0  |  提交时间：2019/04/09