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VDRAS and Polarimetric Radar Investigation of a Bow Echo Formation After a Squall Line Merged With a Preline Convective Cell 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (7)
作者:  Zhou, Ang;  Zhao, Kun;  Lee, Wen-Chau;  Huang, Hao;  Hu, Dongming;  Fu, Paling
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
bow echo  convective merge  VDRAS  polarimetric radar  microphysical processes  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Terrestrial CO2 Fluxes, Concentrations, Sources and Budget in Northeast China: Observational and Modeling Studies 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (6)
作者:  Li, Xiaolan;  Hu, Xiao-Ming;  Cai, Changjie;  Jia, Qingyu;  Zhang, Yao;  Liu, Jingmiao;  Xue, Ming;  Xu, Jianming;  Wen, Rihong;  Crowell, Sean M. R.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
Relationship between the South China Sea summer monsoon withdrawal and September-October rainfall over southern China 期刊论文
CLIMATE DYNAMICS, 2019
作者:  Hu, Peng;  Chen, Wen;  Chen, Shangfeng;  Liu, Yuyun;  Huang, Ruping;  Dong, Shaorou
收藏  |  浏览/下载:6/0  |  提交时间:2020/02/17
South China Sea  Summer monsoon withdrawal  Rainfall  Southern China  Tropical cyclone  Interannual variability  
Initial growth of the Northern Lhasaplano, Tibetan Plateau in the early Late Cretaceous (ca. 92 Ma) 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2019, 131: 1823-1836
作者:  Lai, Wen;  Hu, Xiumian;  Garzanti, Eduardo;  Sun, Gaoyuan;  Garzione, Carmala N.;  Fadel, Marcelle BouDagher;  Ma, Anlin
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation 期刊论文
SCIENCE, 2019, 366 (6464) : 475-+
作者:  Dong, Guohua;  Li, Suzhi;  Yao, Mouteng;  Zhou, Ziyao;  Zhang, Yong-Qiang;  Han, Xu;  Luo, Zhenlin;  Yao, Junxiang;  Peng, Bin;  Hu, Zhongqiang;  Huang, Houbing;  Jia, Tingting;  Li, Jiangyu;  Ren, Wei;  Ye, Zuo-Guang;  Ding, Xiangdong;  Sun, Jun;  Nan, Ce-Wen;  Chen, Long-Qing;  Li, Ju;  Liu, Ming
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Interannual variability and triggers of the South China Sea summer monsoon withdrawal 期刊论文
CLIMATE DYNAMICS, 2019, 53: 4355-4372
作者:  Hu, Peng;  Chen, Wen;  Chen, Shangfeng;  Huang, Ruping
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
South China Sea  Summer monsoon withdrawal  Interannual variability  Intraseasonal oscillations  Tropical cyclones  
Detection and attribution of upper-tropospheric warming over the tropical western Pacific 期刊论文
CLIMATE DYNAMICS, 2019, 53: 3057-3068
作者:  Li, Yana;  Yang, Song;  Deng, Yi;  Hu, Xiaoming;  Cai, Ming;  Zhou, Wen
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
The upper-tropospheric warming  The tropical western Pacific  Long-term change  Attribution analyses  
Statistical analysis of the impacts of intra-seasonal oscillations on the South China Sea summer monsoon withdrawal 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Hu, Peng;  Chen, Wen;  Chen, Shangfeng;  Huang, Ruping
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
30-60-day oscillation  intra-seasonal oscillation  quasi-biweekly oscillation  South China Sea  summer monsoon withdrawal