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Prolonged Periodicity and Eastward Shift of the January North Pacific Oscillation Since the Mid-1990s and Its Linkage With Sea Ice Anomalies in the Barents Sea 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Xu, Zhiqing;  Fan, Ke
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
January North Pacific Oscillation  prolonged periodicity  eastward shift  sea ice anomalies in the Barents Sea  the mid-1990s  
Characterization of submicron particles by time-of-flight aerosol chemical speciation monitor (ToF-ACSM) during wintertime: aerosol composition, sources, and chemical processes in Guangzhou, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7595-7615
作者:  Guo, Junchen;  Zhou, Shengzhen;  Cai, Mingfu;  Zhao, Jun;  Song, Wei;  Zhao, Weixiong;  Hu, Weiwei;  Sun, Yele;  He, Yao;  Yang, Chengqiang;  Xu, Xuezhe;  Zhang, Zhisheng;  Cheng, Peng;  Fan, Qi;  Hang, Jian;  Fan, Shaojia;  Wang, Xinming;  Wang, Xuemei
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/06
Decreased motility of flagellated microalgae long-term acclimated to CO2-induced acidified waters 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (6) : 561-+
作者:  Wang, Yitao;  Fan, Xiao;  Gao, Guang;  Beardall, John;  Inaba, Kazuo;  Hall-Spencer, Jason M.;  Xu, Dong;  Zhang, Xiaowen;  Han, Wentao;  McMinn, Andrew;  Ye, Naihao
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/09
Phase Transition of Enstatite-Ferrosilite Solid Solutions at High Pressure and High Temperature: Constraints on Metastable Orthopyroxene in Cold Subduction 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Xu, Jingui;  Fan, Dawei;  Zhang, Dongzhou;  Guo, Xinzhuan;  Zhou, Wenge;  Dera, Przemyslaw K.
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Production of Ancient Dissolved Organic Carbon in Arctic Ocean Sediment: A Pathway of Carbon Cycling in the Extreme Environment 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Fu, Wenjing;  Qi, Yuanzhi;  Liu, Yanguang;  Wang, Xuchen;  Druffel, Ellen R. M.;  Xu, Xiaomei;  Ren, Peng;  Sun, Shuwen;  Fan, Di
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/02
Strontium isotope stratigraphy and paleomagnetic age constraints on the evolution history of coral reef islands, northern South China Sea 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (3-4) : 803-816
作者:  Fan, Tianlai;  Yu, Kefu;  Zhao, Jianxin;  Jiang, Wei;  Xu, Shendong;  Zhang, Yu;  Wang, Rui;  Wang, Yinghui;  Feng, Yuexing;  Bian, Lizeng;  Qian, Handong;  Liao, Weihua
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Contrasting size-resolved hygroscopicity of fine particles derived by HTDMA and HR-ToF-AMS measurements between summer and winter in Beijing: the impacts of aerosol aging and local emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 915-929
作者:  Fan, Xinxin;  Liu, Jieyao;  Zhang, Fang;  Chen, Lu;  Collins, Don;  Xu, Weiqi;  Jin, Xiaoai;  Ren, Jingye;  Wang, Yuying;  Wu, Hao;  Li, Shangze;  Sun, Yele;  Li, Zhanqing
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Significant contribution of organics to aerosol liquid water content in winter in Beijing, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 901-914
作者:  Jin, Xiaoai;  Wang, Yuying;  Li, Zhanqing;  Zhang, Fang;  Xu, Weiqi;  Sun, Yele;  Fan, Xinxin;  Chen, Guangyu;  Wu, Hao;  Ren, Jingye;  Wang, Qiuyan;  Cribb, Maureen
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02