GSTDTAP

浏览/检索结果: 共187条,第1-10条 帮助

限定条件                    
已选(0)清除 条数/页:   排序方式:
Gainers and losers of surface and terrestrial water resources in China during 1989-2016 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wang, Xinxin;  Xiao, Xiangming;  Zou, Zhenhua;  Dong, Jinwei;  Qin, Yuanwei;  Doughty, Russell B.;  Menarguez, Michael A.;  Chen, Bangqian;  Wang, Junbang;  Ye, Hui;  Ma, Jun;  Zhong, Qiaoyan;  Zhao, Bin;  Li, Bo
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/14
Revealing enigmatic mucus structures in the deep sea using DeepPIV 期刊论文
NATURE, 2020, 583 (7814) : 78-+
作者:  Nguyen, Ngoc Uyen Nhi;  Canseco, Diana C.;  Xiao, Feng;  Nakada, Yuji;  Li, Shujuan;  Lam, Nicholas T.;  Muralidhar, Shalini A.;  Savla, Jainy J.;  Hill, Joseph A.;  Le, Victor;  Zidan, Kareem A.;  El-Feky, Hamed W.;  Wang, Zhaoning;  Ahmed, Mahmoud Salama;  Hubbi, Maimon E.;  Menendez-Montes, Ivan
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/09

Advanced deep-sea imaging tools yield insights into the structure and function of mucus filtration houses built by midwater giant larvaceans.


Many animals build complex structures to aid in their survival, but very few are built exclusively from materials that animals create (1,2). In the midwaters of the ocean, mucoid structures are readily secreted by numerous animals, and serve many vital functions(3,4). However, little is known about these mucoid structures owing to the challenges of observing them in the deep sea. Among these mucoid forms, the '  houses'  of larvaceans are marvels of nature(5), and in the ocean twilight zone giant larvaceans secrete and build mucus filtering structures that can reach diameters of more than 1 m(6). Here we describe in situ laser-imaging technology(7) that reconstructs three-dimensional models of mucus forms. The models provide high-resolution views of giant larvacean houses and elucidate the role that house structure has in food capture and predator avoidance. Now that tools exist to study mucus structures found throughout the ocean, we can shed light on some of nature'  s most complex forms.


  
Decreased motility of flagellated microalgae long-term acclimated to CO2-induced acidified waters 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (6) : 561-+
作者:  Wang, Yitao;  Fan, Xiao;  Gao, Guang;  Beardall, John;  Inaba, Kazuo;  Hall-Spencer, Jason M.;  Xu, Dong;  Zhang, Xiaowen;  Han, Wentao;  McMinn, Andrew;  Ye, Naihao
收藏  |  浏览/下载:13/0  |  提交时间:2020/06/09
The functional roles of species in metacommunities, as revealed by metanetwork analyses of bird-plant frugivory networks 期刊论文
ECOLOGY LETTERS, 2020, 23 (8) : 1252-1262
作者:  Li, Hai-Dong;  Tang, Linfang;  Jia, Chenxi;  Holyoak, Marcel;  Fruend, Jochen;  Huang, Xiaoqun;  Xiao, Zhishu
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/25
Forest fragmentation  metacommunity  metanetwork  multilayer network  seed dispersal  species roles  
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
Darwin's naturalization conundrum can be explained by spatial scale 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (20) : 10904-10910
作者:  Park, Daniel S.;  Feng, Xiao;  Maitner, Brian S.;  Ernst, Kacey C.;  Enquist, Brian J.
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/13
biological invasions  competition  Darwin'  s naturalization hypothesis  environmental filtering  spatial resolution  
Structure of nevanimibe-bound tetrameric human ACAT1 期刊论文
NATURE, 2020, 581 (7808) : 339-U214
作者:  Ma, Xiyu;  Claus, Lucas A. N.;  Leslie, Michelle E.;  Tao, Kai;  Wu, Zhiping;  Liu, Jun;  Yu, Xiao;  Li, Bo;  Zhou, Jinggeng;  Savatin, Daniel V.;  Peng, Junmin;  Tyler, Brett M.;  Heese, Antje;  Russinova, Eugenia;  He, Ping;  Shan, Libo
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/03

The structure of human ACAT1 in complex with the inhibitor nevanimibe is resolved by cryo-electron microscopy.


Cholesterol is an essential component of mammalian cell membranes, constituting up to 50% of plasma membrane lipids. By contrast, it accounts for only 5% of lipids in the endoplasmic reticulum (ER)(1). The ER enzyme sterol O-acyltransferase 1 (also named acyl-coenzyme A:cholesterol acyltransferase, ACAT1) transfers a long-chain fatty acid to cholesterol to form cholesteryl esters that coalesce into cytosolic lipid droplets. Under conditions of cholesterol overload, ACAT1 maintains the low cholesterol concentration of the ER and thereby has an essential role in cholesterol homeostasis(2,3). ACAT1 has also been implicated in Alzheimer'  s disease(4), atherosclerosis(5) and cancers(6). Here we report a cryo-electron microscopy structure of human ACAT1 in complex with nevanimibe(7), an inhibitor that is in clinical trials for the treatment of congenital adrenal hyperplasia. The ACAT1 holoenzyme is a tetramer that consists of two homodimers. Each monomer contains nine transmembrane helices (TMs), six of which (TM4-TM9) form a cavity that accommodates nevanimibe and an endogenous acyl-coenzyme A. This cavity also contains a histidine that has previously been identified as essential for catalytic activity(8). Our structural data and biochemical analyses provide a physical model to explain the process of cholesterol esterification, as well as details of the interaction between nevanimibe and ACAT1, which may help to accelerate the development of ACAT1 inhibitors to treat related diseases.


  
Hidden neural states underlie canary song syntax 期刊论文
NATURE, 2020
作者:  Bao, Han;  Duan, Junlei;  Jin, Shenchao;  Lu, Xingda;  Li, Pengxiong;  Qu, Weizhi;  Wang, Mingfeng;  Novikova, Irina;  Mikhailov, Eugeniy E.;  Zhao, Kai-Feng;  Molmer, Klaus;  Shen, Heng;  Xiao, Yanhong
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Neurons in the canary premotor cortex homologue encode past song phrases and transitions, carrying information relevant to future choice of phrases as '  hidden states'  during song.


Coordinated skills such as speech or dance involve sequences of actions that follow syntactic rules in which transitions between elements depend on the identities and order of past actions. Canary songs consist of repeated syllables called phrases, and the ordering of these phrases follows long-range rules(1)in which the choice of what to sing depends on the song structure many seconds prior. The neural substrates that support these long-range correlations are unknown. Here, using miniature head-mounted microscopes and cell-type-specific genetic tools, we observed neural activity in the premotor nucleus HVC(2-4)as canaries explored various phrase sequences in their repertoire. We identified neurons that encode past transitions, extending over four phrases and spanning up to four seconds and forty syllables. These neurons preferentially encode past actions rather than future actions, can reflect more than one song history, and are active mostly during the rare phrases that involve history-dependent transitions in song. These findings demonstrate that the dynamics of HVC include '  hidden states'  that are not reflected in ongoing behaviour but rather carry information about prior actions. These states provide a possible substrate for the control of syntax transitions governed by long-range rules.


  
The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10414-10421
作者:  Chen, Song-Can;  Sun, Guo-Xin;  Yan, Yu;  Konstantinidis, Konstantinos T.;  Zhang, Si-Yu;  Deng, Ye;  Li, Xiao-Min;  Cui, Hui-Ling;  Musat, Florin;  Popp, Denny;  Rosen, Barry P.;  Zhu, Yong-Guan
收藏  |  浏览/下载:21/0  |  提交时间:2020/05/13
arsenic  detoxification  evolution  oxygen  biogeochemistry  
Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation throughS-palmitoylation (vol 573, pg 139, 2019) (Retraction of Vol 573, Pg 139, 2020) 期刊论文
NATURE, 2020, 583 (7814) : 154-154
作者:  Zhang, Hao;  Liu, Chun-Xiao;  Gazibegovic, Sasa;  Xu, Di;  Logan, John A.;  Wang, Guanzhong;  van Loo, Nick;  Bommer, Jouri D. S.;  de Moor, Michiel W. A.;  Car, Diana;  Op Het Veld, Roy L. M.;  van Veldhoven, Petrus J.;  Koelling, Sebastian;  Verheijen, Marcel A.;  Pendharkar, Mihir;  Pennachio, Daniel J.;  Shojaei, Borzoyeh;  Lee, Joon Sue;  Palmstrom, Chris J.;  Bakkers, Erik P. A. M.;  Sarma, S. Das;  Kouwenhoven, Leo P.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03