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Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Molecular basis for pore blockade of human Na+ channel Na(v)1.2 by the mu-conotoxin KIIIA 期刊论文
SCIENCE, 2019, 363 (6433) : 1309-+
作者:  Pan, Xiaojing;  Li, Zhangqiang;  Huang, Xiaoshuang;  Huang, Gaoxingyu;  Gao, Shuai;  Shen, Huaizong;  Liu, Lei;  Lei, Jianlin;  Yan, Nieng
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Structures of human Na(v)1.7 channel in complex with auxiliary subunits and animal toxins 期刊论文
SCIENCE, 2019, 363 (6433) : 1303-+
作者:  Shen, Huaizong;  Liu, Dongliang;  Wu, Kun;  Lei, Jianlin;  Yan, Nieng
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
De novo design of self-assembling helical protein filaments 期刊论文
SCIENCE, 2018, 362 (6415) : 705-+
作者:  Shen, Hao;  Fallas, Jorge A.;  Lynch, Eric;  Sheffler, William;  Parry, Bradley;  Jannetty, Nicholas;  Decarreau, Justin;  Wagenbach, Michael;  Vicente, Juan Jesus;  Chen, Jiajun;  Wang, Lei;  Dowling, Quinton;  Oberdorfer, Gustav;  Stewart, Lance;  Wordeman, Linda;  De Yoreo, James;  Jacobs-Wagner, Christine;  KolInan, Justin;  Baker, David
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Structural basis for the modulation of voltage-gated sodium channels by animal toxins 期刊论文
SCIENCE, 2018, 362 (6412)
作者:  Shen, Huaizong;  Li, Zhangqiang;  Jiang, Yan;  Pan, Xiaojing;  Wu, Jianping;  Cristofori-Armstrong, Ben;  Smith, Jennifer J.;  Chin, Yanni K. Y.;  Lei, Jianlin;  Zhou, Qiang;  King, Glenn F.;  Yan, Nieng
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Structure of the human voltage-gated sodium channel Na(v)1.4 in complex with beta 1 期刊论文
SCIENCE, 2018, 362 (6412)
作者:  Pan, Xiaojing;  Li, Zhangqiang;  Zhou, Qiang;  Shen, Huaizong;  Wu, Kun;  Huang, Xiaoshuang;  Chen, Jiaofeng;  Zhang, Juanrong;  Zhu, Xuechen;  Lei, Jianlin;  Xiong, Wei;  Gong, Haipeng;  Xiao, Bailong;  Yan, Nieng
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Ordered macro-microporous metal-organic framework single crystals 期刊论文
SCIENCE, SCIENCE, 2018, 2018, 359, 359 (6372) : 206-+, 206-+
作者:  Shen, Kui;  Zhang, Lei;  Chen, Xiaodong;  Liu, Lingmei;  Zhang, Daliang;  Han, Yu;  Chen, Junying;  Long, Jilan;  Luque, Rafael;  Li, Yingwei;  Chen, Banglin
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Interannual cycles of Hantaan virus outbreaks at the human-animal interface in Central China are controlled by temperature and rainfall 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (30) : 8041-8046
作者:  Tian, Huaiyu;  Yu, Pengbo;  Cazelles, Bernard;  Xu, Lei;  Tan, Hua;  Yang, Jing;  Huang, Shanqian;  Xu, Bo;  Cai, Jun;  Ma, Chaofeng;  Wei, Jing;  Li, Shen;  Qu, Jianhui;  Laine, Marko;  Wang, Jingjun;  Tong, Shilu;  Stenseth, Nils Chr.;  Xu, Bing
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27
Hantaan virus  spillover to humans  wildlife reservoir  time-series data  climate change