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Spatial Variation of Reactive Nitrogen Emissions From China's Croplands Codetermined by Regional Urbanization and Its Feedback to Global Climate Change 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Xu, Peng;  Chen, Anping;  Houlton, Benjamin Z.;  Zeng, Zhenzhong;  Wei, Song;  Zhao, Chenxu;  Lu, Haiyan;  Liao, Yajun;  Zheng, Zhonghua;  Luan, Shengji;  Zheng, Yi
收藏  |  浏览/下载:15/0  |  提交时间:2020/06/01
reactive gaseous nitrogen  agricultural soils  emission inventory  urbanization  climate change impacts  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Combined Scattering of Radiation Belt Electrons by Low-Frequency Hiss: Cyclotron, Landau, and Bounce Resonances 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Fu, Song;  Yi, Juan;  Ni, Binbin;  Zhou, Ruoxian;  Hu, Zejun;  Cao, Xing;  Gu, Xudong;  Guo, Deyu
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Pollution exacerbates China's water scarcity and its regional inequality 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Ma, Ting;  Sun, Siao;  Fu, Guangtao;  Hall, Jim W.;  Ni, Yong;  He, Lihuan;  Yi, Jiawei;  Zhao, Na;  Du, Yunyan;  Pei, Tao;  Cheng, Weiming;  Song, Ci;  Fang, Chuanglin;  Zhou, Chenghu
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
Identifying the complex types of atmosphere-ocean interactions in El Ni;o 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (11)
作者:  Song, Wan-Jiao;  Yu, Jin-Yi
收藏  |  浏览/下载:5/0  |  提交时间:2020/02/17
El Ni  o  atmosphere-ocean coupling  ENSO complexity  tropical coupling  subtropical coupling  basin-wide coupling  local coupling  
Contribution of rice variety renewal and agronomic innovations to yield improvement and greenhouse gas mitigation in China 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (11)
作者:  Zhang, Yi;  Jiang, Yu;  Tai, Amos P. K.;  Feng, Jinfei;  Li, Zhijie;  Zhu, Xiangcheng;  Chen, Jin;  Zhang, Jun;  Song, Zhenwei;  Deng, Aixing;  Lal, Rattan;  Zhang, Weijian
收藏  |  浏览/下载:11/0  |  提交时间:2020/02/17
food security  climate change  greenhouse gas mitigation  agronomic practice  rice production  
Measuring daily accessed street greenery: A human-scale approach for informing better urban planning practices 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 191
作者:  Ye, Yu;  Richards, Daniel;  Lu, Yi;  Song, Xiaoping;  Zhuang, Yu;  Zeng, Wei;  Zhong, Teng
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Visible greenery  Google Street View  Space syntax  Human-scale  Accessible greenery  Machine learning  
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Li, Terytty Yang;  Song, Lintao;  Sun, Yu;  Li, Jingyi;  Yi, Cong;  Lam, Sin Man;  Xu, Dijin;  Zhou, Linkang;  Li, Xiaotong;  Yang, Ying;  Zhang, Chen-Song;  Xie, Changchuan;  Huang, Xi;  Shui, Guanghou;  Lin, Shu-Yong;  Reue, Karen;  Lin, Sheng-Cai
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Detection and attribution of upper-tropospheric warming over the tropical western Pacific 期刊论文
CLIMATE DYNAMICS, 2019, 53: 3057-3068
作者:  Li, Yana;  Yang, Song;  Deng, Yi;  Hu, Xiaoming;  Cai, Ming;  Zhou, Wen
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
The upper-tropospheric warming  The tropical western Pacific  Long-term change  Attribution analyses