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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Using Short-Term CO/CO2 Ratios to Assess Air Mass Differences Over the Korean Peninsula During KORUS-AQ 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Halliday, H. S.;  DiGangi, J. P.;  Choi, Y.;  Diskin, G. S.;  Pusede, S. E.;  Rana, M.;  Nowak, J. B.;  Knote, C.;  Ren, X.;  He, H.;  Dickerson, R. R.;  Li, Z.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
carbon monoxide  carbon dioxide  CO  CO2 ratios  Korean air quality  air mass characterization  tracer ratios  
Mid-21st century ozone air quality and health burden in China under emissions scenarios and climate change 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (7)
作者:  Westervelt, D. M.;  Ma, C. T.;  He, M. Z.;  Fiore, A. M.;  Kinney, P. L.;  Kioumourtzoglou, M-A;  Wang, S.;  Xing, J.;  Ding, D.;  Correa, G.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
ozone  climate change  China  health  model  
Large-Amplitude Electromagnetic Ion Cyclotron Waves and Density Fluctuations in the Flank of the Earth's Magnetosheath 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (9) : 4545-4553
作者:  Zhao, J. S.;  Wang, T. Y.;  Dunlop, M. W.;  Shi, C.;  He, J. S.;  Dong, X. C.;  Wu, D. J.;  Giles, B.;  Russell, C. T.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/26
Observations of Flux Ropes With Strong Energy Dissipation in the Magnetotail 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (2) : 580-589
作者:  Huang, S. Y.;  Jiang, K.;  Yuan, Z. G.;  Zhou, M.;  Sahraoui, F.;  Fu, H. S.;  Deng, X. H.;  Khotyaintsev, Yu. V.;  Yu, X. D.;  He, L. H.;  Deng, D.;  Pollock, C. J.;  Torbert, R. B.;  Burch, J. L.
收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09
Scale-invariant magnetoresistance in a cuprate superconductor 期刊论文
SCIENCE, 2018, 361 (6401) : 479-481
作者:  Giraldo-Gallo, P.;  Galvis, J. A.;  Stegen, Z.;  Modic, K. A.;  Balakirev, F. F.;  Betts, J. B.;  Lian, X.;  Moir, C.;  Riggs, S. C.;  Wu, J.;  Bollinger, A. T.;  He, X.;  Bozovic, I.;  Ramshaw, B. J.;  McDonald, R. D.;  Boebinger, G. S.;  Shekhter, A.
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Response to Comment on "Plant diversity increases with the strength of negative density dependence at the global scale" 期刊论文
SCIENCE, 2018, 360 (6391)
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27
Response to Comment on "Plant diversity increases with the strength of negative density dependence at the global scale" 期刊论文
SCIENCE, 2018, 360 (6391)
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27
Extremely low genetic diversity across mangrove taxa reflects past sea level changes and hints at poor future responses 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (4) : 1741-1748
作者:  Guo, Zixiao;  Li, Xinnian;  He, Ziwen;  Yang, Yuchen;  Wang, Wenqing;  Zhong, Cairong;  Greenberg, Anthony J.;  Wu, Chung-I;  Duke, Norman C.;  Shi, Suhua
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
dieback  effective population size  genetic diversity  human disturbance  mangroves  sea level rise  
Biological and geophysical feedbacks with fire in the Earth system 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (3)
作者:  Archibald, S.;  Lehmann, C. E. R.;  Belcher, C. M.;  Bond, W. J.;  Bradstock, R. A.;  Daniau, A-L;  Dexter, K. G.;  Forrestel, E. J.;  Greve, M.;  He, T.;  Higgins, S. I.;  Hoffmann, W. A.;  Lamont, B. B.;  McGlinn, D. J.;  Moncrieff, G. R.;  Osborne, C. P.;  Pausas, J. G.;  Price, O.;  Ripley, B. S.;  Rogers, B. M.;  Schwilk, D. W.;  Simon, M. F.;  Turetsky, M. R.;  Van der Werf, G. R.;  Zanne, A. E.
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
flammability  earth-system feedbacks  niche-construction  evolution  plant traits  vegetation  climate