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CMIP6 Models Predict Significant 21st Century Decline of the Atlantic Meridional Overturning Circulation 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Weijer, W.;  Cheng, W.;  Garuba, O. A.;  Hu, A.;  Nadiga, B. T.
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/25
AMOC  CMIP6  
Structures of human pannexin 1 reveal ion pathways and mechanism of gating 期刊论文
NATURE, 2020
作者:  Krause, David W.;  Hoffmann, Simone;  Hu, Yaoming;  Wible, John R.;  Rougier, Guillermo W.;  Kirk, E. Christopher;  Groenke, Joseph R.;  Rogers, Raymond R.;  Rossie, James B.;  Schultz, Julia A.;  Evans, Alistair R.;  von Koenigswald, Wighart;  Rahantarisoa, Lydia J.
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

Cryo-electron microscopy structures of the ATP-permeable channel pannexin 1 reveal a gating mechanism involving multiple distinct ion-conducting pathways.


Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of physiological functions such as blood pressure regulation(1), apoptotic cell clearance(2) and human oocyte development(3). Here we present several structures of human PANX1 in a heptameric assembly at resolutions of up to 2.8 angstrom, including an apo state, a caspase-7-cleaved state and a carbenoxolone-bound state. We reveal a gating mechanism that involves two ion-conducting pathways. Under normal cellular conditions, the intracellular entry of the wide main pore is physically plugged by the C-terminal tail. Small anions are conducted through narrow tunnels in the intracellular domain. These tunnels connect to the main pore and are gated by a long linker between the N-terminal helix and the first transmembrane helix. During apoptosis, the C-terminal tail is cleaved by caspase, allowing the release of ATP through the main pore. We identified a carbenoxolone-binding site embraced by W74 in the extracellular entrance and a role for carbenoxolone as a channel blocker. We identified a gap-junction-like structure using a glycosylation-deficient mutant, N255A. Our studies provide a solid foundation for understanding the molecular mechanisms underlying the channel gating and inhibition of PANX1 and related large-pore channels.


  
Observation of the Kondo screening cloud 期刊论文
NATURE, 2020, 579 (7798) : 210-+
作者:  Shahnawaz, Mohammad;  Mukherjee, Abhisek;  Pritzkow, Sandra;  Mendez, Nicolas;  Rabadia, Prakruti;  Liu, Xiangan;  Hu, Bo;  Schmeichel, Ann;  Singer, Wolfgang;  Wu, Gang;  Tsai, Ah-Lim;  Shirani, Hamid;  Nilsson, K. Peter R.;  Low, Phillip A.;  Soto, Claudio
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

When a magnetic impurity exists in a metal, conduction electrons form a spin cloud that screens the impurity spin. This basic phenomenon is called the Kondo effect(1,2). Unlike electric-charge screening, the spin-screening cloud(3-6) occurs quantum coherently, forming spin-singlet entanglement with the impurity. Although the spins interact locally around the impurity, the Kondo cloud can theoretically spread out over several micrometres. The cloud has not so far been detected, and so its physical existence-a fundamental aspect of the Kondo effect-remains controversial(7,8). Here we present experimental evidence of a Kondo cloud extending over a length of micrometres, comparable to the theoretical length xi(K). In our device, a Kondo impurity is formed in a quantum dot(2,9-11), coupling on one side to a quasi-one-dimensional channel(12) that houses a Fabry-Perot interferometer of various gate-defined lengths L exceeding one micrometre. When we sweep a voltage on the interferometer end gate-separated by L from the quantum dot-to induce Fabry-Perot oscillations in conductance we observe oscillations in the measured Kondo temperature T-K, which is a signature of the Kondo cloud at distance L. When L is less than xi(K) the T-K oscillation amplitude becomes larger as L becomes smaller, obeying a scaling function of a single parameter L/xi(K), whereas when L is greater than xi(K) the oscillation is much weaker. Our results reveal that xi(K) is the only length parameter associated with the Kondo effect, and that the cloud lies mostly within a length of xi(K). Our experimental method offers a way of detecting the spatial distribution of exotic non-Fermi liquids formed by multiple magnetic impurities or multiple screening channels(13-16) and of studying spin-correlated systems.


  
Metabolic regulation of gene expression by histone lactylation 期刊论文
NATURE, 2019, 574 (7779) : 575-+
作者:  Zhang, Di;  Tang, Zhanyun;  Huang, He;  Zhou, Guolin;  Cui, Chang;  Weng, Yejing;  Liu, Wenchao;  Kim, Sunjoo;  Lee, Sangkyu;  Perez-Neut, Mathew;  Ding, Jun;  Czyz, Daniel;  Hu, Rong;  Ye, Zhen;  He, Maomao;  Zheng, Y. George;  Shuman, Howard A.;  Dai, Lunzhi;  Ren, Bing;  Roeder, Robert G.;  Becker, Lev;  Zhao, Yingming
收藏  |  浏览/下载:28/0  |  提交时间:2019/11/27
Comment on "Revised paleoaltimetry data show low Tibetan Plateau elevation during the Eocene" 期刊论文
SCIENCE, 2019, 365 (6459)
作者:  Valdes, Paul J.;  Lin, Ding;  Farnsworth, Alex;  Spicer, Robert A.;  Li, Shi-Hu;  Tao, Su
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Deposition of Organic and Black Carbon: Direct Measurements at Three Remote Stations in the Himalayas and Tibetan Plateau 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (16) : 9702-9715
作者:  Yan, Fangping;  He, Cenlin;  Kang, Shichang;  Chen, Pengfei;  Hu, Zhaofu;  Han, Xiaowen;  Gautam, Sangita;  Yan, Caiqing;  Zheng, Mei;  Sillanpaa, Mika;  Raymond, Peter A.;  Li, Chaoliu
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Network parameters quantify loss of assemblage structure in human-impacted lake ecosystems 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (11) : 3871-3882
作者:  Wang, Rong;  Dearing, John A.;  Doncaster, C. Patrick;  Yang, Xiangdong;  Zhang, Enlou;  Langdon, Peter G.;  Yang, Hui;  Dobg, Xuhui;  Hu, Zhujun;  Xu, Min;  Zhao, Yanjie;  Shen, Ji
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
biodiversity  diatom assemblages  ecological resilience  network skewness  self-organized system  stability  
Revisiting the Circulation of Hudson Bay: Evidence for a Seasonal Pattern 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (7) : 3891-3899
作者:  Ridenour, Natasha A.;  Hu, Xianmin;  Sydor, Kevin;  Myers, Paul G.;  Barber, David G.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
Hudson Bay  freshwater  anticyclonic circulation  numerical modeling  dynamic topography  atmospheric forcing  
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition 期刊论文
SCIENCE, 2019, 364 (6436) : 184-+
作者:  Hirose, Kentaro;  Payumo, Alexander Y.;  Cutie, Stephen;  Hoang, Alison;  Zhang, Hao;  Guyot, Romain;  Lunn, Dominic;  Bigley, Rachel B.;  Yu, Hongyao;  Wang, Jiajia;  Smith, Megan;  Gillett, Ellen;  Muroy, Sandra E.;  Schmid, Tobias;  Wilson, Emily;  Field, Kenneth A.;  Reeder, DeeAnn M.;  Maden, Malcom;  Yartsev, Michael M.;  Wolfgang, Michael J.;  Grutzner, Frank;  Scanlan, Thomas S.;  Szweda, Luke I.;  Buffenstein, Rochelle;  Hu, Guang;  Flamant, Frederic;  Olgin, Jeffrey E.;  Huang, Guo N.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Convergent regulatory evolution and loss of flight in paleognathous birds 期刊论文
SCIENCE, 2019, 364 (6435) : 74-+
作者:  Sackton, Timothy B.;  Grayson, Phil;  Cloutier, Alison;  Hu, Zhirui;  Liu, Jun S.;  Wheeler, Nicole E.;  Gardner, Paul P.;  Clarke, Julia A.;  Baker, Allan J.;  Clamp, Michele;  Edwards, Scott V.
收藏  |  浏览/下载:90/0  |  提交时间:2019/11/27