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Economics in the Age of COVID-19 期刊论文
NATURE, 2020, 581 (7809) : 375-377
作者:  Yin, Juan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Yang, Meng;  Cao, Yuan;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Shuang-Lin;  Shu, Rong;  Huang, Yong-Mei;  Deng, Lei;  Li, Li;  Zhang, Qiang;  Liu, Nai-Le
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakneck triage nails many diagnoses, but deeper treatment is needed.


Breakneck triage nails many diagnoses, but deeper treatment is needed.


  
Strain engineering and epitaxial stabilization of halide perovskites 期刊论文
NATURE, 2020, 577 (7789) : 209-+
作者:  Chen, Yimu;  Lei, Yusheng;  Li, Yuheng;  Yu, Yugang;  Cai, Jinze;  Chiu, Ming-Hui;  Rao, Rahul;  Gu, Yue;  Wang, Chunfeng;  Choi, Woojin;  Hu, Hongjie;  Wang, Chonghe;  Li, Yang;  Song, Jiawei;  Zhang, Jingxin;  Qi, Baiyan;  Lin, Muyang;  Zhang, Zhuorui;  Islam, Ahmad E.;  Maruyama, Benji;  Dayeh, Shadi;  Li, Lain-Jong;  Yang, Kesong;  Lo, Yu-Hwa;  Xu, Sheng
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/03

Strain engineering is a powerful tool with which to enhance semiconductor device performance(1,2). Halide perovskites have shown great promise in device applications owing to their remarkable electronic and optoelectronic properties(3-5). Although applying strain to halide perovskites has been frequently attempted, including using hydrostatic pressurization(6-8), electrostriction(9), annealing(10-12), van der Waals force(13), thermal expansion mismatch(14), and heat-induced substrate phase transition(15), the controllable and device-compatible strain engineering of halide perovskites by chemical epitaxy remains a challenge, owing to the absence of suitable lattice-mismatched epitaxial substrates. Here we report the strained epitaxial growth of halide perovskite single-crystal thin films on lattice-mismatched halide perovskite substrates. We investigated strain engineering of a-formamidinium lead iodide (alpha-FAPbI(3)) using both experimental techniques and theoretical calculations. By tailoring the substrate composition-and therefore its lattice parameter-a compressive strain as high as 2.4 per cent is applied to the epitaxial alpha-FAPbI(3) thin film. We demonstrate that this strain effectively changes the crystal structure, reduces the bandgap and increases the hole mobility of alpha-FAPbI(3). Strained epitaxy is also shown to have a substantial stabilization effect on the alpha-FAPbI(3) phase owing to the synergistic effects of epitaxial stabilization and strain neutralization. As an example, strain engineering is applied to enhance the performance of an alpha-FAPbI(3)-based photodetector.


  
CAN THE WORLD MAKE ENOUGH CORONAVIRUS VACCINE? 期刊论文
NATURE, 2020, 580 (7805) : 578-580
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Liu, Mingjie;  Jiang, Lei
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


  
DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
Oncometabolites suppress DNA repair by disrupting local chromatin signalling 期刊论文
NATURE, 2020
作者:  Zhang, Xu;  Lei, Bo;  Yuan, Yuan;  Zhang, Li;  Hu, Lu;  Jin, Sen;  Kang, Bilin;  Liao, Xuebin;  Sun, Wenzhi;  Xu, Fuqiang;  Zhong, Yi;  Hu, Ji;  Qi, Hai
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

Metabolites that are elevated in tumours inhibit the lysine demethylase KDM4B, resulting in aberrant hypermethylation of histone 3 lysine 9 and decreased homology-dependent DNA repair.


Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer(1). Increased levels of the metabolites 2-hydroxyglutarate, succinate and fumarate occur in human malignancies owing to somatic mutations in the isocitrate dehydrogenase-1 or -2 (IDH1 or IDH2) genes, or germline mutations in the fumarate hydratase (FH) and succinate dehydrogenase genes (SDHA, SDHB, SDHC and SDHD), respectively(2-4). Recent work has made an unexpected connection between these metabolites and DNA repair by showing that they suppress the pathway of homology-dependent repair (HDR)(5,6) and confer an exquisite sensitivity to inhibitors of poly (ADP-ribose) polymerase (PARP) that are being tested in clinical trials. However, the mechanism by which these oncometabolites inhibit HDR remains poorly understood. Here we determine the pathway by which these metabolites disrupt DNA repair. We show that oncometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking a local H3K9 trimethylation signal that is essential for the proper execution of HDR. Consequently, recruitment of TIP60 and ATM, two key proximal HDR factors, is substantially impaired at DNA breaks, with reduced end resection and diminished recruitment of downstream repair factors. These findings provide a mechanistic basis for oncometabolite-induced HDR suppression and may guide effective strategies to exploit these defects for therapeutic gain.


  
Very regular high-frequency pulsation modes in young intermediate-mass stars 期刊论文
NATURE, 2020, 581 (7807) : 147-+
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Jiang, Lei;  Liu, Mingjie
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Asteroseismology probes the internal structures of stars by using their natural pulsation frequencies(1). It relies on identifying sequences of pulsation modes that can be compared with theoretical models, which has been done successfully for many classes of pulsators, including low-mass solar-type stars(2), red giants(3), high-mass stars(4) and white dwarfs(5). However, a large group of pulsating stars of intermediate mass-the so-called delta Scuti stars-have rich pulsation spectra for which systematic mode identification has not hitherto been possible(6,7). This arises because only a seemingly random subset of possible modes are excited and because rapid rotation tends to spoil regular patterns(8-10). Here we report the detection of remarkably regular sequences of high-frequency pulsation modes in 60 intermediate-mass main-sequence stars, which enables definitive mode identification. The space motions of some of these stars indicate that they are members of known associations of young stars, as confirmed by modelling of their pulsation spectra.


The pulsation spectra of intermediate-mass stars (so-called delta Scuti stars) have been challenging to analyse, but new observations of 60 such stars reveal remarkably regular sequences of high-frequency pulsation modes.


  
Large plasticity in magnesium mediated by pyramidal dislocations 期刊论文
SCIENCE, 2019, 365 (6448) : 73-+
作者:  Liu, Bo-Yu;  Liu, Fei;  Yang, Nan;  Zhai, Xiao-Bo;  Zhang, Lei;  Yang, Yang;  Li, Bin;  Li, Ju;  Ma, Evan;  Nie, Jian-Feng;  Shan, Zhi-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits 期刊论文
SCIENCE, 2019, 364 (6446) : 1152-+
作者:  Chen, Lei;  Qin, Qiang;  Jiang, Yu;  Wang, Kun;  Lin, Zeshan;  Li, Zhipeng;  Bibi, Faysal;  Yang, Yongzhi;  Wang, Jinhuan;  Nie, Wenhui;  Su, Weiting;  Liu, Guichun;  Li, Qiye;  Fu, Weiwei;  Pan, Xiangyu;  Liu, Chang;  Yang, Jie;  Zhang, Chenzhou;  Yin, Yuan;  Wang, Yu;  Zhao, Yue;  Zhang, Chen;  Wang, Zhongkai;  Qin, Yanli;  Liu, Wei;  Wang, Bao;  Ren, Yandong;  Zhang, Ru;  Zeng, Yan;  da Fonseca, Rute R.;  Wei, Bin;  Li, Ran;  Wan, Wenting;  Zhao, Ruoping;  Zhu, Wenbo;  Wang, Yutao;  Duan, Shengchang;  Gao, Yun;  Zhang, Yong E.;  Chen, Chunyan;  Hvilsom, Christina;  Epps, Clinton W.;  Chemnick, Leona G.;  Doug, Yang;  Mirarab, Siavash;  Siegismund, Hans Redlef;  Ryder, Oliver A.;  Gilbert, M. Thomas P.;  Lewin, Harris A.;  Zhang, Guojie;  Heller, Rasmus;  Wang, Wen
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/27
Genetic basis of ruminant headgear and rapid antler regeneration 期刊论文
SCIENCE, 2019, 364 (6446) : 1153-+
作者:  Wang, Yu;  Zhang, Chenzhou;  Wang, Nini;  Li, Zhipeng;  Heller, Rasmus;  Liu, Rong;  Zhao, Yue;  Han, Jiangang;  Pan, Xiangyu;  Zheng, Zhuqing;  Dai, Xueqin;  Chen, Ceshi;  Dou, Mingle;  Peng, Shujun;  Chen, Xianqing;  Liu, Jing;  Li, Ming;  Wang, Kun;  Liu, Chang;  Lin, Zeshan;  Chen, Lei;  Hao, Fei;  Zhu, Wenbo;  Song, Chengchuang;  Zhao, Chen;  Zheng, Chengli;  Wang, Jianming;  Hu, Shengwei;  Li, Cunyuan;  Yang, Hui;  Jiang, Lin;  Li, Guangyu;  Liu, Mingjun;  Sonstegard, Tad S.;  Zhang, Guojie;  Jiang, Yu;  Wang, Wen;  Qiu, Qiang
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Double-negative-index ceramic aerogels for thermal superinsulation 期刊论文
SCIENCE, 2019, 363 (6428) : 723-+
作者:  Xu, Xiang;  Zhang, Qiangqiang;  Hao, Menglong;  Hu, Yuan;  Lin, Zhaoyang;  Peng, Lele;  Wang, Tao;  Ren, Xuexin;  Wang, Chen;  Zhao, Zipeng;  Wan, Chengzhang;  Fei, Huilong;  Wang, Lei;  Zhu, Jian;  Sun, Hongtao;  Chen, Wenli;  Du, Tao;  Deng, Biwei;  Cheng, Gary J.;  Shakir, Imran;  Dames, Chris;  Fisher, Timothy S.;  Zhang, Xiang;  Li, Hui;  Huang, Yu;  Duan, Xiangfeng
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27