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Heavy air pollution with a unique "non-stagnant" atmospheric boundary layer in the Yangtze River middle basin aggravated by regional transport of PM2.5 over China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7217-7230
作者:  Yu, Chao;  Zhao, Tianliang;  Bai, Yongqing;  Zhang, Lei;  Kong, Shaofei;  Yu, Xingna;  He, Jinhai;  Cui, Chunguang;  Yang, Jie;  You, Yingchang;  Ma, Guoxu;  Wu, Ming;  Chang, Jiacheng
收藏  |  浏览/下载：11/0  |  提交时间：2020/06/29
DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
Chemical Differences Between PM1 and PM2.5 in Highly Polluted Environment and Implications in Air Pollution Studies 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Sun, Yele;  He, Yao;  Kuang, Ye;  Xu, Wanyun;  Song, Shaojie;  Ma, Nan;  Tao, Jiangchuan;  Cheng, Peng;  Wu, Cheng;  Su, Hang;  Cheng, Yafang;  Xie, Conghui;  Chen, Chun;  Lei, Lu;  Qiu, Yanmei;  Fu, Pingqing;  Croteau, Philip;  Worsnop, Douglas R.
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/02
Fine particle characterization in a coastal city in China: composition, sources, and impacts of industrial emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 2877-2890
作者:  Lei, Lu;  Xie, Conghui;  Wang, Dawei;  He, Yao;  Wang, Qingqing;  Zhou, Wei;  Hu, Wei;  Fu, Pingqing;  Chen, Yong;  Pan, Xiaole;  Wang, Zifa;  Worsnop, Douglas;  Sun, Yele
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/02
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).