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A century on, does BCG have a future? 新闻
来源平台：CNRS News. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：33/0  |  提交时间：2021/08/10
Human-driven habitat change leads to physical, behavioral change in mosquitofish 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：33/0  |  提交时间：2021/07/26
Engineers apply physics-informed machine learning to solar cell production 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：4/0  |  提交时间：2021/06/15
How do slow anomalies beneath subducting slabs affect giant megathrust earthquakes? 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：5/0  |  提交时间：2021/04/29
The Emigration Life Cycle: How Development Shapes Emigration from Poor Countries 新闻
来源平台：Canadian Institute of Mining, Metallurgy and Petroleum. 发布日期：2020
作者:  admin
收藏  |  浏览/下载：1/0  |  提交时间：2020/08/24
Evaluation of land-atmosphere processes of the Polar WRF in the summertime Arctic tundra 期刊论文
ATMOSPHERIC RESEARCH, 2020, 240
作者:  Kim, Jeongwon;  Lee, Junhong;  Hong, Je-Woo;  Hong, Jinkyu;  Koo, Ja-Ho;  Kim, Joo-Hong;  Yun, Juyeol;  Nam, Sungjin;  Jung, Ji Young;  Choi, Taejin;  Lee, Bang Yong
收藏  |  浏览/下载：14/0  |  提交时间：2020/08/18
Polar WRF  Arctic tundra  Land-atmosphere interaction  Surface energy balance  Soil moisture  Planetary boundary layer  
Subduction megathrust heterogeneity characterized from 3D seismic data 期刊论文
NATURE GEOSCIENCE, 2020, 13 (5)
作者:  Kirkpatrick, James D.;  Edwards, Joel H.;  Verdecchia, Alessandro;  Kluesner, Jared W.;  Harrington, Rebecca M.;  Silver, Eli A.
收藏  |  浏览/下载：9/0  |  提交时间：2020/05/13
Lithological and structural controls on river profiles and networks in the northern Sierra Nevada (California, USA) 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (3-4) : 655-667
作者:  Gabet, Emmanuel J.
收藏  |  浏览/下载：3/0  |  提交时间：2020/07/02
A very high-resolution assessment and modelling of urban air quality 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 625-647
作者:  Wolf, Tobias;  Pettersson, Lasse H.;  Esau, Igor
收藏  |  浏览/下载：5/0  |  提交时间：2020/07/02
Genomic basis for RNA alterations in cancer 期刊论文
NATURE, 2020, 578 (7793) : 129-+
作者:  Petitprez, Florent;  39;han
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/03

Transcript alterations often result from somatic changes in cancer genomes(1). Various forms of RNA alterations have been described in cancer, including overexpression(2), altered splicing(3) and gene fusions(4)  however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples have been analysed by both transcriptome and whole-genome sequencing. Here we present, to our knowledge, the most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(5). Using matched whole-genome sequencing data, we associated several categories of RNA alterations with germline and somatic DNA alterations, and identified probable genetic mechanisms. Somatic copy-number alterations were the major drivers of variations in total gene and allele-specific expression. We identified 649 associations of somatic single-nucleotide variants with gene expression in cis, of which 68.4% involved associations with flanking non-coding regions of the gene. We found 1,900 splicing alterations associated with somatic mutations, including the formation of exons within introns in proximity to Alu elements. In addition, 82% of gene fusions were associated with structural variants, including 75 of a new class, termed '  bridged'  fusions, in which a third genomic location bridges two genes. We observed transcriptomic alteration signatures that differ between cancer types and have associations with variations in DNA mutational signatures. This compendium of RNA alterations in the genomic context provides a rich resource for identifying genes and mechanisms that are functionally implicated in cancer.