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Study finds water quality improvements in Maryland's Choptank River 新闻
来源平台:EurekAlert. 发布日期:2021
作者:  admin
收藏  |  浏览/下载:0/0  |  提交时间:2021/01/28
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours 期刊论文
NATURE, 2020, 577 (7792) : 689-+
作者:  Toll, Velle;  Christensen, Matthew;  Quaas, Johannes;  Bellouin, Nicolas
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

In a mouse model of glioblastoma, treatment with VEGF-C increases lymphatic drainage in the central nervous system and improves the immune response, suggesting that modulating meningeal lymphatics could enhance checkpoint inhibitor therapy.


Immune surveillance against pathogens and tumours in the central nervous system is thought to be limited owing to the lack of lymphatic drainage. However, the characterization of the meningeal lymphatic network has shed light on previously unappreciated ways that an immune response can be elicited to antigens that are expressed in the brain(1-3). Despite progress in our understanding of the development and structure of the meningeal lymphatic system, the contribution of this network in evoking a protective antigen-specific immune response in the brain remains unclear. Here, using a mouse model of glioblastoma, we show that the meningeal lymphatic vasculature can be manipulated to mount better immune responses against brain tumours. The immunity that is mediated by CD8 T cells to the glioblastoma antigen is very limited when the tumour is confined to the central nervous system, resulting in uncontrolled tumour growth. However, ectopic expression of vascular endothelial growth factor C (VEGF-C) promotes enhanced priming of CD8 T cells in the draining deep cervical lymph nodes, migration of CD8 T cells into the tumour, rapid clearance of the glioblastoma and a long-lasting antitumour memory response. Furthermore, transfection of an mRNA construct that expresses VEGF-C works synergistically with checkpoint blockade therapy to eradicate existing glioblastoma. These results reveal the capacity of VEGF-C to promote immune surveillance of tumours, and suggest a new therapeutic approach to treat brain tumours.


  
Rivers across the Siberian Arctic unearth the patterns of carbon release from thawing permafrost 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (21) : 10280-10285
作者:  Wild, Birgit;  Andersson, August;  Broder, Lisa;  Vonk, Jorien;  Hugelius, Gustaf;  McClelland, James W.;  Song, Wenjun;  Raymond, Peter A.;  Gustafsson, Orjan
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
carbon cycle  climate change  radiocarbon  peat  leaching  
NSF-supported scientists present research results on Earth's critical zone at 2017 AGU fall meeting 新闻
来源平台:US National Scientific Foundation (NSF). 发布日期:2017
作者:  admin
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/17