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Global soil‐derived ammonia emissions from agricultural nitrogen fertilizer application: A refinement based on regional and crop‐specific emission factors 期刊论文
Global Change Biology, 2020
作者:  Ruoya Ma;  Jianwen Zou;  Zhaoqiang Han;  Kai Yu;  Shuang Wu;  Zhaofu Li;  Shuwei Liu;  Shuli Niu;  William R. Horwath;  Xia Zhu‐;  Barker
收藏  |  浏览/下载:14/0  |  提交时间:2020/11/30
Adapting to the challenges of warming 期刊论文
Science, 2020
作者:  Steven C. Sherwood
收藏  |  浏览/下载:22/0  |  提交时间:2020/11/20
Environmental and anthropogenic drivers of soil methane fluxes in forests: Global patterns and among‐biomes differences 期刊论文
Global Change Biology, 2020
作者:  Gabriel Gatica;  Marí;  a E. Ferná;  ndez;  Maria P. Juliarena;  Javier Gyenge
收藏  |  浏览/下载:12/0  |  提交时间:2020/09/30
Can biomass supply meet the demands of bioenergy with carbon capture and storage (BECCS)? 期刊论文
Global Change Biology, 2020
作者:  Michael B. Jones;  Fabrizio Albanito
收藏  |  浏览/下载:1/0  |  提交时间:2020/08/25
Human impacts on polycyclic aromatic hydrocarbon distribution in Chinese intertidal zones 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Lv, Min;  Luan, Xiaolin;  Liao, Chunyang;  Wang, Dongqi;  Liu, Dongyan;  Zhang, Gan;  Jiang, Guibin;  Chen, Lingxin
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/06
Climate change mitigation potential in sanitation via off-site composting of human waste 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (6) : 545-+
作者:  McNicol, Gavin;  Jeliazovski, Julie;  Francois, Junior Jules;  Kramer, Sasha;  Ryals, Rebecca
收藏  |  浏览/下载:6/0  |  提交时间:2020/06/09
Global patterns and controlling factors of soil nitrification rate 期刊论文
Global Change Biology, 2020
作者:  Zhaolei Li;  Zhaoqi Zeng;  Dashuan Tian;  Jinsong Wang;  Zheng Fu;  Fangyue Zhang;  Ruiyang Zhang;  Weinan Chen;  Yiqi Luo;  Shuli Niu
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/20
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline 期刊论文
NATURE, 2020, 581 (7806) : 70-+
作者:  Doherty, Tiarnan A. S.;  Winchester, Andrew J.;  Macpherson, Stuart;  Johnstone, Duncan N.;  Pareek, Vivek;  Tennyson, Elizabeth M.;  Kosar, Sofiia;  Kosasih, Felix U.;  Anaya, Miguel;  Abdi-Jalebi, Mojtaba;  Andaji-Garmaroudi, Zahra;  Wong, E. Laine;  Madeo, Julien;  Chiang, Yu-Hsien;  Park, Ji-Sang;  Jung, Young-Kwang;  Petoukhoff, Christopher E.;  Divitini, Giorgio;  Man, Michael K. L.;  Ducati, Caterina;  Walsh, Aron;  Midgley, Paul A.;  Dani, Keshav M.;  Stranks, Samuel D.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakdown of the blood-brain barrier in individuals carrying the epsilon 4 allele of the APOE gene, but not the epsilon 3 allele, increases with and predicts cognitive impairment and is independent of amyloid beta or tau pathology.


Vascular contributions to dementia and Alzheimer'  s disease are increasingly recognized(1-6). Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction(7), including the early clinical stages of Alzheimer'  s disease(5,8-10). The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer'  s disease(11-14), leads to accelerated breakdown of the BBB and degeneration of brain capillary pericytes(15-19), which maintain BBB integrity(20-22). It is unclear, however, whether the cerebrovascular effects of APOE4 contribute to cognitive impairment. Here we show that individuals bearing APOE4 (with the epsilon 3/epsilon 4 or epsilon 4/epsilon 4 alleles) are distinguished from those without APOE4 (epsilon 3/epsilon 3) by breakdown of the BBB in the hippocampus and medial temporal lobe. This finding is apparent in cognitively unimpaired APOE4 carriers and more severe in those with cognitive impairment, but is not related to amyloid-beta or tau pathology measured in cerebrospinal fluid or by positron emission tomography(23). High baseline levels of the BBB pericyte injury biomarker soluble PDGFR beta(7,8) in the cerebrospinal fluid predicted future cognitive decline in APOE4 carriers but not in non-carriers, even after controlling for amyloid-beta and tau status, and were correlated with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in cerebrospinal fluid. Our findings suggest that breakdown of the BBB contributes to APOE4-associated cognitive decline independently of Alzheimer'  s disease pathology, and might be a therapeutic target in APOE4 carriers.


  
Sandy coastlines under threat of erosion 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (3) : 260-+
作者:  Vousdoukas, Michalis, I;  Ranasinghe, Roshanka;  Mentaschi, Lorenzo;  Plomaritis, Theocharis A.;  Athanasiou, Panagiotis;  Luijendijk, Arjen;  Feyen, Luc
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/13
Improved estimates on global carbon stock and carbon pools in tidal wetlands 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Ouyang, Xiaoguang;  Lee, Shing Yip
收藏  |  浏览/下载:4/0  |  提交时间:2020/05/13