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Not all driver mutations are equal 期刊论文
NATURE, 2020, 580 (7805) : 595-596
作者:  Legendre, Lucas J.;  Rubilar-Rogers, David;  Musser, Grace M.;  Davis, Sarah N.;  Otero, Rodrigo A.;  Vargas, Alexander O.;  Clarke, Julia A.
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

A study of cancer-associated mutations in normal endometrial glands of the uterus has now been performed using whole-genome sequencing. The analysis sheds light on the early changes that lead to invasive disease.


  
Mutations in colon cancer match bacterial signature 期刊论文
NATURE, 2020, 580 (7802)
作者:  Gray, Alison C.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/03

Studies have pointed to a link between colon cancer and a gut bacterium that produces DNA-damaging molecules. The discovery of a mutational signature linked to these bacteria in human colon cancer supports this association.


  
The treacheries of adaptation 期刊论文
SCIENCE, 2019, 366 (6464) : 418-419
作者:  Miller, Craig R.
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
Mobilizing Mutations Human Genetics in the Age of Patient Advocacy 期刊论文
SCIENCE, 2019, 365 (6460) : 1386-1386
作者:  Wilbrecht, Linda
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
How to lose tumor suppression 期刊论文
SCIENCE, 2019, 365 (6453) : 539-540
作者:  Lane, David Philip
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
Mutated clones are the new normal 期刊论文
SCIENCE, 2019, 364 (6444) : 938-939
作者:  Tomasetti, Cristian
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
The paradox of mutations and cancer 期刊论文
SCIENCE, 2018, 362 (6417) : 893-894
作者:  Chanock, Stephen J.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Contingency and determinism in evolution: Replaying life's tape 期刊论文
SCIENCE, 2018, 362 (6415)
作者:  Blount, Zachary D.;  Lenski, Richard E.;  Losos, Jonathan B.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Response to Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification" 期刊论文
SCIENCE, 2018, 361 (6409)
作者:  Chen, Lixin;  Liu, Pingfang;  Evans, Thomas C., Jr.;  Ettwiller, Laurence M.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Paternally inherited cis-regulatory structural variants are associated with autism 期刊论文
SCIENCE, 2018, 360 (6386) : 327-330
作者:  Brandler, William M.;  Antaki, Danny;  Gujral, Madhusudan;  Kleiber, Morgan L.;  Whitney, Joe;  Maile, Michelle S.;  Hong, Oanh;  Chapman, Timothy R.;  Tan, Shirley;  Tandon, Prateek;  Pang, Timothy;  Tang, Shih C.;  Vaux, Keith K.;  Yang, Yan;  Harrington, Eoghan;  Juul, Sissel;  Turner, Daniel J.;  Thiruvahindrapuram, Bhooma;  Kaur, Gaganjot;  Wang, Zhuozhi;  Kingsmore, Stephen F.;  Gleeson, Joseph G.;  Bisson, Denis;  Kakaradov, Boyko;  Telenti, Amalio;  Venter, J. Craig;  Corominas, Roser;  Toma, Claudio;  Cormand, Bru;  Rueda, Isabel;  Guijarro, Silvina;  Messer, Karen S.;  Nievergelt, Caroline M.;  Arranz, Maria J.;  Courchesne, Eric;  Pierce, Karen;  Muotri, Alysson R.;  Iakoucheva, Lilia M.;  Hervas, Amaia;  Scherer, Stephen W.;  Corsello, Christina;  Sebat, Jonathan
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27