GSTDTAP

浏览/检索结果: 共64条,第1-10条 帮助

限定条件                        
已选(0)清除 条数/页:   排序方式:
Nuclear force probed at short distances 期刊论文
NATURE, 2020, 578 (7796) : 524-525
作者:  Shukla, Aditi;  Yen, Jenny;  Pagano, Daniel J.;  Dodso, Anne E.;  Fei, Yuhan;  Gorham, Josh;  Seidman, J. G.;  Wickens, Marvin;  Kennedy, Scott
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

The dense soup of matter in the core of neutron stars is hard to model, but particle-accelerator experiments in which energetic electrons scatter off atomic nuclei could help to explore this high-density regime.


A test of effective nucleon-nucleon interactions at short separations.


  
To set coronavirus policy, model lives and livelihoods in lockstep 期刊论文
NATURE, 2020, 581 (7809) : 357-357
作者:  Landhuis, Esther
收藏  |  浏览/下载:4/0  |  提交时间:2020/07/03

Economists must improve tools to weigh trade-offs between health and wealth, says Andy Haldane.


Economists must improve tools to weigh trade-offs between health and wealth, says Andy Haldane.


  
Gut microbes tune inflammation and lifespan in a mouse model of amyotrophic lateral sclerosis 期刊论文
NATURE, 2020, 582 (7810) : 34-35
作者:  Mega, Emiliano Rodriguez
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

The microbiota modulates amyotrophic lateral sclerosis in an animal model.


There is growing evidence that gut microbes can influence disease. Analysis of a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis offers insight into how gut bacteria might contribute to this illness.


  
Russian science: the quest for reform 期刊论文
NATURE, 2020, 579 (7799) : 332-346
作者:  Khamsi, Roxanne
收藏  |  浏览/下载:1/0  |  提交时间:2020/07/03

Some researchers see promise in planned reforms. Credit: Alexei DruzhininTASS via Getty


Some researchers see promise in planned reforms.


  
Measuring and forecasting progress towards the education-related SDG targets 期刊论文
NATURE, 2020, 580 (7805) : 636-+
作者:  Hindell, Mark A.;  Reisinger, Ryan R.;  Ropert-Coudert, Yan;  Huckstadt, Luis A.;  Trathan, Philip N.;  Bornemann, Horst;  Charrassin, Jean-Benoit;  Chown, Steven L.;  Costa, Daniel P.;  Danis, Bruno;  Lea, Mary-Anne;  Thompson, David;  Torres, Leigh G.;  Van de Putte, Anton P.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Education is a key dimension of well-being and a crucial indicator of development(1-4). The Sustainable Development Goals (SDGs) prioritize progress in education, with a new focus on inequality(5-7). Here we model the within-country distribution of years of schooling, and use this model to explore educational inequality since 1970 and to forecast progress towards the education-related 2030 SDG targets. We show that although the world is largely on track to achieve near-universal primary education by 2030, substantial challenges remain in the completion rates for secondary and tertiary education. Globally, the gender gap in schooling had nearly closed by 2018 but gender disparities remained acute in parts of sub-Saharan Africa, and North Africa and the Middle East. It is predicted that, by 2030, females will have achieved significantly higher educational attainment than males in 18 countries. Inequality in education reached a peak globally in 2017 and is projected to decrease steadily up to 2030. The distributions and inequality metrics presented here represent a framework that can be used to track the progress of each country towards the SDG targets and the level of inequality over time. Reducing educational inequality is one way to promote a fairer distribution of human capital and the development of more equitable human societies.


Great progress toward the education-related SDG targets has been made  however, global estimates of within-country distributions of education reveal gender disparities and high levels of total inequality in many parts of the world.


  
A distributional code for value in dopamine-based reinforcement learning 期刊论文
NATURE, 2020, 577 (7792) : 671-+
作者:  House, Robert A.;  Maitra, Urmimala;  Perez-Osorio, Miguel A.;  Lozano, Juan G.;  Jin, Liyu;  Somerville, James W.;  Duda, Laurent C.;  Nag, Abhishek;  Walters, Andrew;  Zhou, Ke-Jin;  Roberts, Matthew R.;  Bruce, Peter G.
收藏  |  浏览/下载:61/0  |  提交时间:2020/07/03

Since its introduction, the reward prediction error theory of dopamine has explained a wealth of empirical phenomena, providing a unifying framework for understanding the representation of reward and value in the brain(1-3). According to the now canonical theory, reward predictions are represented as a single scalar quantity, which supports learning about the expectation, or mean, of stochastic outcomes. Here we propose an account of dopamine-based reinforcement learning inspired by recent artificial intelligence research on distributional reinforcement learning(4-6). We hypothesized that the brain represents possible future rewards not as a single mean, but instead as a probability distribution, effectively representing multiple future outcomes simultaneously and in parallel. This idea implies a set of empirical predictions, which we tested using single-unit recordings from mouse ventral tegmental area. Our findings provide strong evidence for a neural realization of distributional reinforcement learning.


Analyses of single-cell recordings from mouse ventral tegmental area are consistent with a model of reinforcement learning in which the brain represents possible future rewards not as a single mean of stochastic outcomes, as in the canonical model, but instead as a probability distribution.


  
MODELLING THE PANDEMIC The simulations driving the world's response to COVID-19 期刊论文
NATURE, 2020, 580 (7803) : 316-318
作者:  Kusner, Matt J.
收藏  |  浏览/下载:0/0  |  提交时间:2020/07/03

How epidemiologists rushed to model the coronavirus pandemic.


How epidemiologists rushed to model the coronavirus pandemic.


  
Neuroscience Engineering a picky eater 期刊论文
NATURE, 2020, 579 (7799) : 345-346
作者:  Carrasco, Nancy
收藏  |  浏览/下载:0/0  |  提交时间:2020/07/03

Neurogenetic tools commonly used in model organisms have now been adapted to investigate feeding behaviour in the fly Drosophila sechellia. The experiments shed light on why this fly is such a fussy eater.


  
Oceanic forcing of penultimate deglacial and last interglacial sea-level rise 期刊论文
NATURE, 2020, 577 (7792) : 660-+
作者:  Rizal, Yan;  Westaway, Kira E.;  Zaim, Yahdi;  van den Bergh, Gerrit D.;  Bettis, E. Arthur, III;  Morwood, Michael J.;  Huffman, O. Frank;  Grun, Rainer;  Joannes-Boyau, Renaud;  Bailey, Richard M.;  Sidarto;  Westaway, Michael C.;  Kurniawan, Iwan;  Moore, Mark W.;  Storey, Michael;  Aziz, Fachroel;  Suminto;  Zhao, Jian-xin;  Aswan;  Sipola, Maija E.;  Larick, Roy;  Zonneveld, John-Paul;  Scott, Robert;  Putt, Shelby;  Ciochon, Russell L.
收藏  |  浏览/下载:21/0  |  提交时间:2020/05/13

Sea-level histories during the two most recent deglacial-interglacial intervals show substantial differences(1-3) despite both periods undergoing similar changes in global mean temperature(4,5) and forcing from greenhouse gases(6). Although the last interglaciation (LIG) experienced stronger boreal summer insolation forcing than the present interglaciation(7), understanding why LIG global mean sea level may have been six to nine metres higher than today has proven particularly challenging(2). Extensive areas of polar ice sheets were grounded below sea level during both glacial and interglacial periods, with grounding lines and fringing ice shelves extending onto continental shelves(8). This suggests that oceanic forcing by subsurface warming may also have contributed to ice-sheet loss(9-12) analogous to ongoing changes in the Antarctic(13,14) and Greenland(15) ice sheets. Such forcing would have been especially effective during glacial periods, when the Atlantic Meridional Overturning Circulation (AMOC) experienced large variations on millennial timescales(16), with a reduction of the AMOC causing subsurface warming throughout much of the Atlantic basin(9,12,17). Here we show that greater subsurface warming induced by the longer period of reduced AMOC during the penultimate deglaciation can explain the more-rapid sea-level rise compared with the last deglaciation. This greater forcing also contributed to excess loss from the Greenland and Antarctic ice sheets during the LIG, causing global mean sea level to rise at least four metres above modern levels. When accounting for the combined influences of penultimate and LIG deglaciation on glacial isostatic adjustment, this excess loss of polar ice during the LIG can explain much of the relative sea level recorded by fossil coral reefs and speleothems at intermediate- and far-field sites.


  
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours 期刊论文
NATURE, 2020, 577 (7792) : 689-+
作者:  Toll, Velle;  Christensen, Matthew;  Quaas, Johannes;  Bellouin, Nicolas
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

In a mouse model of glioblastoma, treatment with VEGF-C increases lymphatic drainage in the central nervous system and improves the immune response, suggesting that modulating meningeal lymphatics could enhance checkpoint inhibitor therapy.


Immune surveillance against pathogens and tumours in the central nervous system is thought to be limited owing to the lack of lymphatic drainage. However, the characterization of the meningeal lymphatic network has shed light on previously unappreciated ways that an immune response can be elicited to antigens that are expressed in the brain(1-3). Despite progress in our understanding of the development and structure of the meningeal lymphatic system, the contribution of this network in evoking a protective antigen-specific immune response in the brain remains unclear. Here, using a mouse model of glioblastoma, we show that the meningeal lymphatic vasculature can be manipulated to mount better immune responses against brain tumours. The immunity that is mediated by CD8 T cells to the glioblastoma antigen is very limited when the tumour is confined to the central nervous system, resulting in uncontrolled tumour growth. However, ectopic expression of vascular endothelial growth factor C (VEGF-C) promotes enhanced priming of CD8 T cells in the draining deep cervical lymph nodes, migration of CD8 T cells into the tumour, rapid clearance of the glioblastoma and a long-lasting antitumour memory response. Furthermore, transfection of an mRNA construct that expresses VEGF-C works synergistically with checkpoint blockade therapy to eradicate existing glioblastoma. These results reveal the capacity of VEGF-C to promote immune surveillance of tumours, and suggest a new therapeutic approach to treat brain tumours.