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Combining climate, economic, and social policy builds public support for climate action in the US 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (5)
作者:  Bergquist, Parrish;  Mildenberger, Matto;  Stokes, Leah C.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
green new deal  climate  politics  economy  social policy  policy bundling  public opinion  
Equitable resilience in flood prone urban areas in Sri Lanka: A case study in Colombo Divisional Secretariat Division 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2020, 62
作者:  Hewawasam, Vindya;  Matsui, Kenichi
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Equitable resilience  Vulnerability  Flood prone urban areas  Colombo Divisional Secretariat Division  Social vulnerability  Equity  
Exploring spillover effects of ecological lands: A spatial multilevel hedonic price model of the housing market in Wuhan, China 期刊论文
ECOLOGICAL ECONOMICS, 2020, 170
作者:  Liu, Tian;  Hu, Weiyan;  Song, Yan;  Zhang, Anlu
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Spillover effect  Ecological compensation  Ecological lands  Spatial multilevel hedonic model  Non-linear spatial spillover  
Geographic versus institutional drivers of nitrogen footprints: a comparison of two urban universities 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (4)
作者:  MacDonald, Graham K.;  Talbot, Julie;  Moore, Tim R.;  Arsenault, Julien;  McCourt, Sibeal;  Goertzen, Aidan;  Kessler-Nadeau, Max Emile;  Manaugh, Kevin;  Maranger, Roxane;  Robinson, Brian E.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
footprint  reactive nitrogen  sustainability  urban geography  food production  wastewater  higher education  
Repetitive floods intensify outmigration and climate gentrification in coastal cities 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (3)
作者:  de Koning, Koen;  Filatova, Tatiana
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
agent-based model  flood risk  climate gentrification  housing market  climate change  regime shift  
Late-stage oxidative C(sp(3))-H methylation 期刊论文
NATURE, 2020, 580 (7805) : 621-+
作者:  Fessler, Evelyn;  Eckl, Eva-Maria;  Schmitt, Sabine;  Mancilla, Igor Alves;  Meyer-Bender, Matthias F.;  Hanf, Monika;  Philippou-Massier, Julia;  Krebs, Stefan;  Zischka, Hans;  Jae, Lucas T.
收藏  |  浏览/下载:46/0  |  提交时间:2020/07/03

Frequently referred to as the '  magic methyl effect'  , the installation of methyl groups-especially adjacent (alpha) to heteroatoms-has been shown to dramatically increase the potency of biologically active molecules(1-3). However, existing methylation methods show limited scope and have not been demonstrated in complex settings(1). Here we report a regioselective and chemoselective oxidative C(sp(3))-H methylation method that is compatible with late-stage functionalization of drug scaffolds and natural products. This combines a highly site-selective and chemoselective C-H hydroxylation with a mild, functional-group-tolerant methylation. Using a small-molecule manganese catalyst, Mn(CF3PDP), at low loading (at a substrate/catalyst ratio of 200) affords targeted C-H hydroxylation on heterocyclic cores, while preserving electron-neutral and electron-rich aryls. Fluorine- or Lewis-acid-assisted formation of reactive iminium or oxonium intermediates enables the use of a mildly nucleophilic organoaluminium methylating reagent that preserves other electrophilic functionalities on the substrate. We show this late-stage C(sp(3))-H methylation on 41 substrates housing 16 different medicinally important cores that include electron-rich aryls, heterocycles, carbonyls and amines. Eighteen pharmacologically relevant molecules with competing sites-including drugs (for example, tedizolid) and natural products-are methylated site-selectively at the most electron rich, least sterically hindered position. We demonstrate the syntheses of two magic methyl substrates-an inverse agonist for the nuclear receptor RORc and an antagonist of the sphingosine-1-phosphate receptor-1-via late-stage methylation from the drug or its advanced precursor. We also show a remote methylation of the B-ring carbocycle of an abiraterone analogue. The ability to methylate such complex molecules at late stages will reduce synthetic effort and thereby expedite broader exploration of the magic methyl effect in pursuit of new small-molecule therapeutics and chemical probes.


A manganese-catalysed oxidative C(sp(3))-H methylation method allows a methyl group to be selectively installed into medicinally important heterocycles, providing a way to improve pharmaceuticals and better understand the '  magic methyl effect'  .


  
Buildings as a global carbon sink 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (4) : 269-+
作者:  Churkina, Galina;  Organschi, Alan;  Reyer, Christopher P. O.;  Ruff, Andrew;  Vinke, Kira;  Liu, Zhu;  Reck, Barbara K.;  Graedel, T. E.;  Schellnhuber, Hans Joachim
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
River bank instability from unsustainable sand mining in the lower Mekong River 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (3) : 217-+
作者:  Hackney, Christopher R.;  Darby, Stephen E.;  Parsons, Daniel R.;  Leyland, Julian;  Best, James L.;  Aalto, Rolf;  Nicholas, Andrew P.;  Houseago, Robert C.
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
A multi-taxa functional diversity assessment of the effects of eco-estate development in the mixed land-use mosaic of the KwaZulu-Natal North Coast, South Africa 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 192
作者:  Alexander, Jarryd;  Smith, David A. Ehlers;  Smith, Yvette C. Ehlers;  Downs, Colleen T.
收藏  |  浏览/下载:17/0  |  提交时间:2020/02/17
Functional richness  Functional evenness  Functional divergence  Urbanisation  Agriculture  Land transformation  Development  Multi-taxa  
Modeling the willingness to pay for energy efficient residence in urban residential sector in China 期刊论文
ENERGY POLICY, 2019, 135
作者:  Jia, Jun-Jun;  Wu, Hua-Qing;  Nie, Hong-Guang;  Fan, Ying
收藏  |  浏览/下载:6/0  |  提交时间:2020/02/17
Willingness to pay  Energy efficient residence  Residential sector  Consumer choice model  Probit model  Interval regression model