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Multiple drivers of the North Atlantic warming hole 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (7) : 667-+
作者:  Keil, Paul;  Mauritsen, Thorsten;  Jungclaus, Johann;  Hedemann, Christopher;  Olonscheck, Dirk;  Ghosh, Rohit
收藏  |  浏览/下载：8/0  |  提交时间：2020/07/06
Sea-ice loss amplifies summertime decadal CO(2)increase in the western Arctic Ocean 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (7) : 678-+
作者:  Ouyang, Zhangxian;  Qi, Di;  Chen, Liqi;  Takahashi, Taro;  Zhong, Wenli;  DeGrandpre, Michael D.;  Chen, Baoshan;  Gao, Zhongyong;  Nishino, Shigeto;  Murata, Akihiko;  Sun, Heng;  Robbins, Lisa L.;  Jin, Meibing;  Cai, Wei-Jun
收藏  |  浏览/下载：15/0  |  提交时间：2020/06/22
Quantifying the drivers and predictability of seasonal changes in African fire 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Yu, Yan;  Mao, Jiafu;  Thornton, Peter E.;  Notaro, Michael;  Wullschleger, Stan D.;  Shi, Xiaoying;  Hoffman, Forrest M.;  Wang, Yaoping
收藏  |  浏览/下载：9/0  |  提交时间：2020/06/16
Sick plants in grassland communities: a growth-defense trade-off is the main driver of fungal pathogen abundance 期刊论文
ECOLOGY LETTERS, 2020
作者:  Cappelli, Seraina L.;  Pichon, Noemie A.;  Kempel, Anne;  Allan, Eric
收藏  |  浏览/下载：9/0  |  提交时间：2020/06/01
Biodiversity experiment  functional traits  fungal exclusion experiment  fungal pathogen  growth-defense trade-off  nitrogen enrichment  
Intraspecific difference among herbivore lineages and their host-plant specialization drive the strength of trophic cascades 期刊论文
ECOLOGY LETTERS, 2020, 23 (8) : 1242-1251
作者:  Sentis, Arnaud;  Bertram, Raphael;  Dardenne, Nathalie;  Simon, Jean-Christophe;  Magro, Alexandra;  Pujol, Benoit;  Danchin, Etienne;  Hemptinne, Jean-Louis
收藏  |  浏览/下载：27/0  |  提交时间：2020/05/13
Evo-to-eco  genetic variation  herbivory  host-plant adaptation  indirect effects  tri-trophic interactions  
Ghosts of the past: how drought legacy effects shape forest functioning and carbon cycling 期刊论文
ECOLOGY LETTERS, 2020, 23 (5) : 891-901
作者:  Kannenberg, Steven A.;  Schwalm, Christopher R.;  Anderegg, William R. L.
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/02
Carbon allocation  drought recovery  gross primary productivity  growth lags  
Nutrient dilution and climate cycles underlie declines in a dominant insect herbivore 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (13) : 7271-7275
作者:  Welti, Ellen A. R.;  Roeder, Karl A.;  de Beurs, Kirsten M.;  Joern, Anthony;  Kaspari, Michael
收藏  |  浏览/下载：6/0  |  提交时间：2020/05/13
insect decline  global change  grasshopper  Acrididae  grassland  
Recent responses to climate change reveal the drivers of species extinction and survival 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (8) : 4211-4217
作者:  Roman-Palacios, Cristian;  Wiens, John J.
收藏  |  浏览/下载：4/0  |  提交时间：2020/05/13
climate change  disperal  extinction  niche shift  
Dispersal Reduction: Causes, Genomic Mechanisms, and Evolutionary Consequences 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2020, 35 (6) : 512-522
作者:  Waters, J. M.;  Emerson, B. C.;  Arribas, P.;  McCulloch, G. A.
收藏  |  浏览/下载：5/0  |  提交时间：2020/05/13
Genomic basis for RNA alterations in cancer 期刊论文
NATURE, 2020, 578 (7793) : 129-+
作者:  Petitprez, Florent;  39;han
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/03

Transcript alterations often result from somatic changes in cancer genomes(1). Various forms of RNA alterations have been described in cancer, including overexpression(2), altered splicing(3) and gene fusions(4)  however, it is difficult to attribute these to underlying genomic changes owing to heterogeneity among patients and tumour types, and the relatively small cohorts of patients for whom samples have been analysed by both transcriptome and whole-genome sequencing. Here we present, to our knowledge, the most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)(5). Using matched whole-genome sequencing data, we associated several categories of RNA alterations with germline and somatic DNA alterations, and identified probable genetic mechanisms. Somatic copy-number alterations were the major drivers of variations in total gene and allele-specific expression. We identified 649 associations of somatic single-nucleotide variants with gene expression in cis, of which 68.4% involved associations with flanking non-coding regions of the gene. We found 1,900 splicing alterations associated with somatic mutations, including the formation of exons within introns in proximity to Alu elements. In addition, 82% of gene fusions were associated with structural variants, including 75 of a new class, termed '  bridged'  fusions, in which a third genomic location bridges two genes. We observed transcriptomic alteration signatures that differ between cancer types and have associations with variations in DNA mutational signatures. This compendium of RNA alterations in the genomic context provides a rich resource for identifying genes and mechanisms that are functionally implicated in cancer.