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Wind, sun, and wildlife: do wind and solar energy development 'short-circuit' conservation in the western United States? 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (7)
作者:  Agha, Mickey;  Lovich, Jeffrey E.;  Ennen, Joshua R.;  Todd, Brian D.
收藏  |  浏览/下载：13/0  |  提交时间：2020/08/18
renewable energy development  wildlife impacts  desert southwest  
Experimental evidence of dispersal of invasive cyprinid inside waterfowl 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (27) : 15397-15399
作者:  Lovas-Kiss, Adam;  Vincze, Orsolya;  Loki, Viktor;  Paller-Kapusi, Felicia;  Halasi-Kovacs, Bela;  Kovacs, Gyula;  Green, Andy J.;  Lukacs, Balazs Andras
收藏  |  浏览/下载：6/0  |  提交时间：2020/06/29
long-distance dispersal  freshwater  fish distribution  invasion  endozoochory  
Shifting economic activity to services has limited potential to reduce global environmental impacts due to the household consumption of labour 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (6)
作者:  Greenford, D. Horen;  Crownshaw, T.;  Lesk, C.;  Stadler, K.;  Matthews, H. D.
收藏  |  浏览/下载：9/0  |  提交时间：2020/08/18
input-output  sustainable development  green growth  decoupling  climate impacts  land use  water consumption  
Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy 期刊论文
NATURE, 2020, 578 (7794) : 273-+
作者:  Senior, Andrew W.;  Evans, Richard;  Jumper, John;  Kirkpatrick, James;  Sifre, Laurent;  Green, Tim;  Qin, Chongli;  Zidek, Augustin;  Nelson, Alexander W. R.;  Bridgland, Alex;  Penedones, Hugo;  Petersen, Stig;  Simonyan, Karen;  Crossan, Steve;  Kohli, Pushmeet;  Jones, David T.;  Silver, David;  Kavukcuoglu, Koray;  Hassabis, Demis
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/03

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of alpha-synuclein, including Parkinson'  s disease, dementia with Lewy bodies and multiple system atrophy(1). Clinically, it is challenging to differentiate Parkinson'  s disease and multiple system atrophy, especially at the early stages of disease(2). Aggregates of alpha-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of alpha-synuclein that can self-propagate and spread from cell to cell(3-6). Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect alpha-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity(7,8). Here we show that the alpha-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson'  s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%. We used a combination of biochemical, biophysical and biological methods to analyse the product of alpha-synuclein-PMCA, and found that the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid could be used to readily distinguish between Parkinson'  s disease and multiple system atrophy. We also found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar to those of aggregates that were amplified from the brain. These findings suggest that alpha-synuclein aggregates that are associated with Parkinson'  s disease and multiple system atrophy correspond to different conformational strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA. Our results may help to improve our understanding of the mechanism of alpha-synuclein misfolding and the structures of the aggregates that are implicated in different synucleinopathies, and may also enable the development of a biochemical assay to discriminate between Parkinson'  s disease and multiple system atrophy.


Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson'  s disease and patients with multiple system atrophy on the basis of the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid.


  
The Clean Development Mechanism and large dam development: contradictions associated with climate financing in Cambodia 期刊论文
CLIMATIC CHANGE, 2019
作者:  Baird, Ian G.;  Green, W. Nathan
收藏  |  浏览/下载：6/0  |  提交时间：2020/02/17
Clean Development Mechanism  Hydropower dam  Lower Sesan 2  Climate change mitigation  Cambodia  
Does gender inequality affect household green consumption behaviour in China? 期刊论文
ENERGY POLICY, 2019, 135
作者:  Li, Jiajia;  Zhang, Jian;  Zhang, Dayong;  Ji, Qiang
收藏  |  浏览/下载：7/0  |  提交时间：2020/02/17
Gender inequality  Green consumption  Households  CGSS  China  
Assessing opportunities for scaling out, up and deep of win-win solutions for a sustainable world 期刊论文
CLIMATIC CHANGE, 2019
作者:  Omann, Ines;  Kammerlander, Moritz;  Jaeger, Jill;  Bisaro, Alexander;  David Tabara, J.
收藏  |  浏览/下载：7/0  |  提交时间：2020/02/17
How afforestation affects the water cycle in drylands: A process-based comparative analysis 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  Schwaerzel, Kai;  Zhang, Lulu;  Montanarella, Luca;  Wang, Yanhui;  Sun, Ge
收藏  |  浏览/下载：8/0  |  提交时间：2020/02/17
afforestation  climate change  green and blue flows  soil and water conservation  soil erosion control  United Nations Sustainable Development Goals  water cycle in drylands  water scarcity management  
Daily minimum temperature and precipitation control on spring phenology in arid-mountain ecosystems in China 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Du, Jun;  Li, Kai;  He, Zhibin;  Chen, Longfei;  Lin, Pengfei;  Zhu, Xi
收藏  |  浏览/下载：6/0  |  提交时间：2020/02/17
arid mountain ecosystems  climate change  daily minimum temperature  NDVI  precipitation  spring phenology  
Compact and green urban development?towards a framework to assess urban development for a high-density metropolis 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (11)
作者:  Fan, Peilei;  Lee, Ying-Chieh;  Ouyang, Zutao;  Huang, Shu-Li
收藏  |  浏览/下载：9/0  |  提交时间：2020/02/17
compactness  centrality  poly-centrality  planning  Taipei