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RGF1 controls root meristem size through ROS signalling 期刊论文
NATURE, 2020, 577 (7788) : 85-+
作者:  Yamada, Masashi;  Han, Xinwei;  Benfey, Philip N.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

The stem cell niche and the size of the root meristem in plants are maintained by intercellular interactions and signalling networks involving a peptide hormone, root meristem growth factor 1 (RGF1)(1). Understanding how RGF1 regulates the development of the root meristem is essential for understanding stem cell function. Although five receptors for RGF1 have been identified(2-4), the downstream signalling mechanism remains unknown. Here we report a series of signalling events that follow RGF1 activity. We find that the RGF1-receptor pathway controls the distribution of reactive oxygen species (ROS) along the developmental zones of the Arabidopsis root. We identify a previously uncharacterized transcription factor, RGF1-INDUCIBLE TRANSCRIPTION FACTOR 1 (RITF1), that has a central role in mediating RGF1 signalling. Manipulating RITF1 expression leads to the redistribution of ROS along the root developmental zones. Changes in ROS distribution in turn enhance the stability of the PLETHORA2 protein, a master regulator of root stem cells. Our results thus clearly depict a signalling cascade that is initiated by RGF1, linking this peptide to mechanisms that regulate ROS.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Differential soil fungus accumulation and density dependence of trees in a subtropical forest 期刊论文
SCIENCE, 2019, 366 (6461) : 124-+
作者:  Chen, Lei;  Swenson, Nathan G.;  Ji, Niuniu;  Mi, Xiangcheng;  Ren, Haibao;  Guo, Liangdong;  Ma, Keping
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Reorganization of surviving mammal communities after the end-Pleistocene megafaunal extinction 期刊论文
SCIENCE, 2019, 365 (6459) : 1305-+
作者:  Toth, Aniko B.;  Lyons, S. Kathleen;  Barr, W. Andrew;  Behrensmeyer, Anna K.;  Blois, Jessica L.;  Bobe, Rene;  Davis, Matt;  Du, Andrew;  Eronen, Jussi T.;  Faith, J. Tyler;  Fraser, Danielle;  Gotelli, Nicholas J.;  Graves, Gary R.;  Jukar, Advait M.;  Miller, Joshua H.;  Pineda-Munoz, Silvia;  Soul, Laura C.;  Villasenor, Amelia;  Alroy, John
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Structure, spatial dynamics, and stability of novel seed dispersal mutualistic networks in Hawai'i 期刊论文
SCIENCE, 2019, 364 (6435) : 78-+
作者:  Vizentin-Bugoni, Jeferson;  Tarwater, Corey E.;  Foster, Jeffrey T.;  Drake, Donald R.;  Gleditsch, Jason M.;  Hruska, Amy M.;  Kelley, J. Patrick;  Sperry, Jinelle H.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Herbivores as drivers of negative density dependence in tropical forest saplings 期刊论文
SCIENCE, 2019, 363 (6432) : 1213-+
作者:  Forrister, Dale L.;  Endara, Maria-Jose;  Younkin, Gordon C.;  Coley, Phyllis D.;  Kursar, Thomas A.
收藏  |  浏览/下载:2/0  |  提交时间:2019/11/27
Metabolic asymmetry and the global diversity of marine predators 期刊论文
SCIENCE, 2019, 363 (6425) : 366-+
作者:  Grady, John M.;  Maitner, Brian S.;  Winter, Ara S.;  Kaschner, Kristin;  Tittensor, Derek P.;  Record, Sydne;  Smith, Felisa A.;  Wilson, Adam M.;  Dell, Anthony I.;  Zarnetske, Phoebe L.;  Wearing, Helen J.;  Alfaro, Brian;  Brown, James H.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Microbial ecosystem dynamics drive fluctuating nitrogen loss in marine anoxic zones 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (15) : 7220-7225
作者:  Penn, Justin L.;  Weber, Thomas;  Chang, Bonnie X.;  Deutsch, Curtis
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
microbial ecology  oxygen minimum zones  nitrogen cycle  species oscillations  
Diversity partitioning in Phanerozoic benthic marine communities 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (1) : 79-83
作者:  Hofmann, Richard;  Tietje, Melanie;  Aberhan, Martin
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
biodiversity  biotic interactions  beta diversity  alpha diversity  paleoecology  
Plio-Pleistocene decline of African megaherbivores: No evidence for ancient hominin impacts 期刊论文
SCIENCE, 2018, 362 (6417) : 938-+
作者:  Faith, J. Tyler;  Rowan, John;  Du, Andrew;  Koch, Paul L.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27