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A population of dust-enshrouded objects orbiting the Galactic black hole 期刊论文
NATURE, 2020, 577 (7790) : 337-+
作者:  Witze, Alexandra
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/03

The central 0.1 parsecs of the Milky Way host a supermassive black hole identified with the position of the radio and infrared source Sagittarius A* (refs.(1,2)), a cluster of young, massive stars (the S stars3) and various gaseous features(4,5). Recently, two unusual objects have been found to be closely orbiting Sagittarius A*: the so-called G sources, G1 and G2. These objects are unresolved (having a size of the order of 100 astronomical units, except at periapse, where the tidal interaction with the black hole stretches them along the orbit) and they show both thermal dust emission and line emission from ionized gas(6-10). G1 and G2 have generated attention because they appear to be tidally interacting with the supermassive Galactic black hole, possibly enhancing its accretion activity. No broad consensus has yet been reached concerning their nature: the G objects show the characteristics of gas and dust clouds but display the dynamical properties of stellar-mass objects. Here we report observations of four additional G objects, all lying within 0.04 parsecs of the black hole and forming a class that is probably unique to this environment. The widely varying orbits derived for the six G objects demonstrate that they were commonly but separately formed.


  
A heated response to danger 期刊论文
NATURE, 2020, 580 (7802)
作者:  Perry, Keston
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/03

Psychological stress can trigger physiological responses, including an increase in body temperature. A neural circuit that underlies this stress-induced heat response has been identified.


  
Not all driver mutations are equal 期刊论文
NATURE, 2020, 580 (7805) : 595-596
作者:  Legendre, Lucas J.;  Rubilar-Rogers, David;  Musser, Grace M.;  Davis, Sarah N.;  Otero, Rodrigo A.;  Vargas, Alexander O.;  Clarke, Julia A.
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

A study of cancer-associated mutations in normal endometrial glands of the uterus has now been performed using whole-genome sequencing. The analysis sheds light on the early changes that lead to invasive disease.


  
The Twitter hashtag that put a spotlight on racism in academia 期刊论文
NATURE, 2020, 582 (7812) : 327-327
作者:  Lee, Yang;  Warne, Tony;  Nehme, Rony;  Pandey, Shubhi;  Dwivedi-Agnihotri, Hemlata;  Chaturvedi, Madhu;  Edwards, Patricia C.;  Garcia-Nafria, Javier;  Leslie, Andrew G. W.;  Shukla, Arun K.;  Tate, Christopher G.
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03
Let minority-ethnic scientists share 期刊论文
NATURE, 2020, 582 (7812) : 319-319
作者:  Pacheco, Gustavo Gavrel
收藏  |  浏览/下载:1/0  |  提交时间:2020/07/03
IN PURSUIT OF CREATIVE LIBERTY 期刊论文
NATURE, 2020, 579 (7799) : 458-458
作者:  Zhang, Zhenwei;  Will, Cindy L.;  Bertram, Karl;  Dybkov, Olexandr;  Hartmuth, Klaus;  Agafonov, Dmitry E.;  Hofele, Romina;  Urlaub, Henning;  Kastner, Berthold;  Luehrmann, Reinhard;  Stark, Holger
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/03
Everyone, everywhere: the global challenge of climate change Two manifestos call for climate action on different scales - national and global 期刊论文
NATURE, 2020, 579 (7800) : 488-489
作者:  Mallapaty, Smriti
收藏  |  浏览/下载:2/0  |  提交时间:2020/07/03
International evaluation of an AI system for breast cancer screening 期刊论文
NATURE, 2020, 577 (7788) : 89-+
作者:  McKinney, Scott Mayer;  Sieniek, Marcin;  Godbole, Varun;  Godwin, Jonathan;  Antropova, Natasha;  Ashrafian, Hutan;  Back, Trevor;  Chesus, Mary;  Corrado, Greg C.;  Darzi, Ara;  Etemadi, Mozziyar;  Garcia-Vicente, Florencia;  Gilbert, Fiona J.;  Halling-Brown, Mark;  Hassabis, Demis;  Jansen, Sunny;  Karthikesalingam, Alan;  Kelly, Christopher J.;  King, Dominic;  Ledsam, Joseph R.;  Melnick, David;  Mostofi, Hormuz;  Peng, Lily;  Reicher, Joshua Jay;  Romera-Paredes, Bernardino;  Sidebottom, Richard;  Suleyman, Mustafa;  Tse, Daniel;  Young, Kenneth C.;  De Fauw, Jeffrey;  Shetty, Shravya
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Screening mammography aims to identify breast cancer at earlier stages of the disease, when treatment can be more successful(1). Despite the existence of screening programmes worldwide, the interpretation of mammograms is affected by high rates of false positives and false negatives(2). Here we present an artificial intelligence (AI) system that is capable of surpassing human experts in breast cancer prediction. To assess its performance in the clinical setting, we curated a large representative dataset from the UK and a large enriched dataset from the USA. We show an absolute reduction of 5.7% and 1.2% (USA and UK) in false positives and 9.4% and 2.7% in false negatives. We provide evidence of the ability of the system to generalize from the UK to the USA. In an independent study of six radiologists, the AI system outperformed all of the human readers: the area under the receiver operating characteristic curve (AUC-ROC) for the AI system was greater than the AUC-ROC for the average radiologist by an absolute margin of 11.5%. We ran a simulation in which the AI system participated in the double-reading process that is used in the UK, and found that the AI system maintained non-inferior performance and reduced the workload of the second reader by 88%. This robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening.


  
A Galactic-scale gas wave in the solar neighbourhood 期刊论文
NATURE, 2020, 578 (7794) : 237-+
作者:  Alves, Joao;  Zucker, Catherine;  Goodman, Alyssa A.;  Speagle, Joshua S.;  Meingast, Stefan;  Robitaille, Thomas;  Finkbeiner, Douglas P.;  Schlafly, Edward F.;  Green, Gregory M.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

The three-dimensional structure of all cloud complexes in the solar neighbourhood is revealed, showing a narrow and coherent 2.7-kpc arrangement of dense gas, in disagreement with the Gould Belt model.


For the past 150 years, the prevailing view of the local interstellar medium has been based on a peculiarity known as the Gould Belt(1-4), an expanding ring of young stars, gas and dust, tilted about 20 degrees to the Galactic plane. However, the physical relationship between local gas clouds has remained unknown because the accuracy in distance measurements to such clouds is of the same order as, or larger than, their sizes(5-7). With the advent of large photometric surveys(8) and the astrometric survey(9), this situation has changed(10). Here we reveal the three-dimensional structure of all local cloud complexes. We find a narrow and coherent 2.7-kiloparsec arrangement of dense gas in the solar neighbourhood that contains many of the clouds thought to be associated with the Gould Belt. This finding is inconsistent with the notion that these clouds are part of a ring, bringing the Gould Belt model into question. The structure comprises the majority of nearby star-forming regions, has an aspect ratio of about 1:20 and contains about three million solar masses of gas. Remarkably, this structure appears to be undulating, and its three-dimensional shape is well described by a damped sinusoidal wave on the plane of the Milky Way with an average period of about 2 kiloparsecs and a maximum amplitude of about 160 parsecs.


  
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer (vol 575, pg 380, 2019) 期刊论文
NATURE, 2020, 577 (7791) : E7-E7
作者:  Momcilovic, Milica;  Jones, Anthony;  Bailey, Sean T.;  Waldmann, Christopher M.;  Li, Rui;  Lee, Jason T.;  Abdelhady, Gihad;  Gomez, Adrian;  Holloway, Travis;  Schmid, Ernst;  Stout, David;  Fishbein, Michael C.;  Stiles, Linsey;  Dabir, Deepa V.;  Dubinett, Steven M.;  Christofk, Heather;  Shirihai, Orian;  Koehler, Carla M.;  Sadeghi, Saman;  Shackelford, David B.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03