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Lactonization as a general route to beta-C(sp(3))-H functionalization 期刊论文
NATURE, 2020, 577 (7792) : 656-+
作者:  Washington, Harriet A.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Functionalization of the beta-C-H bonds of aliphatic acids is emerging as a valuable synthetic disconnection that complements a wide range of conjugate addition reactions(1-5). Despite efforts for beta-C-H functionalization in carbon-carbon and carbon-heteroatom bond-forming reactions, these have numerous crucial limitations, especially for industrial-scale applications, including lack of mono-selectivity, use of expensive oxidants and limited scope(6-13). Notably, the majority of these reactions are incompatible with free aliphatic acids without exogenous directing groups. Considering the challenge of developing C-H activation reactions, it is not surprising that achieving different transformations requires independent catalyst design and directing group optimizations in each case. Here we report a Pd-catalysed beta-C(sp(3))-H lactonization of aliphatic acids enabled by a mono-N-protected beta-amino acid ligand. The highly strained and reactive beta-lactone products are versatile linchpins for the mono-selective installation of diverse alkyl, alkenyl, aryl, alkynyl, fluoro, hydroxyl and amino groups at the beta position of the parent acid, thus providing a route to many carboxylic acids. The use of inexpensive tert-butyl hydrogen peroxide as the oxidant to promote the desired selective reductive elimination from the Pd(IV) centre, as well as the ease of product purification without column chromatography, render this reaction amenable to tonne-scale manufacturing.


  
Multi-heteroatom-doped carbon from waste-yeast biomass for sustained water splitting 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (7) : 556-+
作者:  Tiwari, Jitendra N.;  Dang, Ngoc Kim;  Sultan, Siraj;  Thangavel, Pandiarajan;  Jeong, Hu Young;  Kim, Kwang S.
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
Using yeast to sustainably remediate and extract heavy metals from waste waters 期刊论文
NATURE SUSTAINABILITY, 2020, 3 (4) : 303-+
作者:  Sun, George L.;  Reynolds, Erin. E.;  Belcher, Angela M.
收藏  |  浏览/下载:3/0  |  提交时间:2020/05/13
X-rays glimpse solid hydrogen's structure 期刊论文
NATURE, 2019, 573 (7775) : 504-505
作者:  Monserrat, Bartomeu;  Pickard, Chris J.
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27
Associations between High Temperature, Heavy Rainfall, and Diarrhea among Young Children in Rural Tamil Nadu, India: A Prospective Cohort Study 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2019, 127 (4)
作者:  Mertens, Andrew;  Balakrishnan, Kalpana;  Ramaswamy, Padmavathi;  Rajkumar, Paramasivan;  Ramaprabha, Prabhakar;  Durairaj, Natesan;  Hubbard, Alan E.;  Khush, Ranjiv;  Colford, John M., Jr.;  Arnold, Benjamin F.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
Evidence for the impact of the 8.2-kyBP climate event on Near Eastern early farmers 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (35) : 8705-8709
作者:  Roffet-Salque, Melanie;  Marciniak, Arkadiusz;  Valdes, Paul J.;  Pawlowska, Kamilla;  Pyzel, Joanna;  Czerniak, Lech;  Krueger, Marta;  Roberts, C. Neil;  Pitter, Sharmini;  Evershed, Richard P.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
archaeology  climate  lipid residue analyses  hydrogen isotopes  animal bones  
ENERGY TECHNOLOGY Negative-emissions hydrogen energy 期刊论文
NATURE CLIMATE CHANGE, 2018, 8 (7) : 560-561
作者:  Yan, Jinyue
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
The global potential for converting renewable electricity to negative-CO2-emissions hydrogen 期刊论文
NATURE CLIMATE CHANGE, 2018, 8 (7) : 621-+
作者:  Rau, Greg H.;  Willauer, Heather D.;  Ren, Zhiyong Jason
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Net-zero emissions energy systems 期刊论文
SCIENCE, 2018, 360 (6396) : 1419-+
作者:  Davis, Steven J.;  Lewis, Nathan S.;  Shaner, Matthew;  Aggarwal, Sonia;  Arent, Doug;  Azevedo, Ines L.;  Benson, Sally M.;  Bradley, Thomas;  Brouwer, Jack;  Chiang, Yet-Ming;  Clack, Christopher T. M.;  Cohen, Armond;  Doig, Stephen;  Edmonds, Jae;  Fennell, Paul;  Field, Christopher B.;  Hannegan, Bryan;  Hodge, Bri-Mathias;  Hoffert, Martin I.;  Ingersoll, Eric;  Jaramillo, Paulina;  Lackner, Klaus S.;  Mach, Katharine J.;  Mastrandrea, Michael;  Ogden, Joan;  Peterson, Per F.;  Sanchez, Daniel L.;  Sperling, Daniel;  Stagner, Joseph;  Trancik, Jessika E.;  Yang, Chi-Jen;  Caldeira, Ken
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27
Early anthropogenic impact on Western Central African rainforests 2,600 y ago 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (13) : 3261-3266
作者:  Garcin, Yannick;  Deschamps, Pierre;  Menot, Guillemette;  de Saulieu, Geoffroy;  Schefuss, Enno;  Sebag, David;  Dupont, Lydie M.;  Oslisly, Richard;  Brademann, Brian;  Mbusnum, Kevin G.;  Onana, Jean-Michel;  Ako, Andrew A.;  Epp, Laura S.;  Tjallingii, Rik;  Strecker, Manfred R.;  Brauer, Achim;  Sachse, Dirk
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Western Central Africa  late Holocene  rainforest crisis  paleohydrology  human activity