Mechanism for Clastogenic Activity of Naphthalene. Quarterly Technical Progress Report

doi:10.2172/1239176

GSTDTAP > 地球科学

DOI	10.2172/1239176
报告编号	LLNL--TR-682042
来源ID	OSTI ID: 1239176
	Mechanism for Clastogenic Activity of Naphthalene. Quarterly Technical Progress Report
	Buchholz, B. A.
	2016-02-05
出版年	2016
页数	6
语种	英语
国家	美国
领域	地球科学
英文摘要	The project has two main goals: 1) Identify the types of adducts naphthalene (NA) forms with DNA and 2) determine whether adduct formation correlates with site selective tumor formation in defined subcompartments of the respiratory tract (respiratory and olfactory nasal epithelium and airways of mice, rats and rhesus monkeys). Five tasks are associated with the completion of the goals. Task 1: Contracting and Animal Use Approvals. IACUC and ACURO approvals are complete. The subcontract with UC Davis (UCD) was executed in December 2014. Task 2: Perform In Vitro Study for Goal 1. Rat and mouse samples exposures completed. Monkey samples need to be exposed in next quarter. Task 3: Perform In Vitro Study for Goal 2. Mouse and rat ex vivo exposures completed. Monkey samples need to be completed in the next quarter. Task 4: Sample Preparation and Analysis. Mouse and Rat Goal 2 samples completed. Monkey samples remain to be done for Goal 2. Rat samples completed for Goal 1. Mouse and Monkey samples for Goal 1 need to be completed. Task 5: Data Interpretation and Reporting. Poster will be presented at 2016 Society of Toxicology Meeting. Outline for paper on adduct formation complete and similar to poster for SOT meeting.
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来源平台	US Department of Energy (DOE)
引用统计
文献类型	科技报告
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/7305
专题	地球科学
推荐引用方式 GB/T 7714	Buchholz, B. A.. Mechanism for Clastogenic Activity of Naphthalene. Quarterly Technical Progress Report,2016.