Radiation Leukemogenesis at Low Dose Rates

doi:10.2172/1093865

GSTDTAP > 地球科学

DOI	10.2172/1093865
报告编号	DOE-CSU--63946-3
来源ID	OSTI ID: 1093865
	Radiation Leukemogenesis at Low Dose Rates
	Weil, Michael; Ullrich, Robert
	2013-09-25
出版年	2013
页数	14
语种	英语
国家	美国
领域	地球科学
英文摘要	The major goals of this program were to study the efficacy of low dose rate radiation exposures for the induction of acute myeloid leukemia (AML) and to characterize the leukemias that are caused by radiation exposures at low dose rate. An irradiator facility was designed and constructed that allows large numbers of mice to be irradiated at low dose rates for protracted periods (up to their life span). To the best of our knowledge this facility is unique in the US and it was subsequently used to study radioprotectors being developed for radiological defense (PLoS One. 7(3), e33044, 2012) and is currently being used to study the role of genetic background in susceptibility to radiation-induced lung cancer. One result of the irradiation was expected; low dose rate exposures are ineffective in inducing AML. However, another result was completely unexpected; the irradiated mice had a very high incidence of hepatocellular carcinoma (HCC), approximately 50%. It was unexpected because acute exposures are ineffective in increasing HCC incidence above background. This is a potential important finding for setting exposure limits because it supports the concept of an 'inverse dose rate effect' for some tumor types. That is, for the development of some tumor types low dose rate exposures carry greater risks than acute exposures.
英文关键词	low dose rate radiation
URL	查看原文
来源平台	US Department of Energy (DOE)
引用统计
文献类型	科技报告
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/6297
专题	地球科学
推荐引用方式 GB/T 7714	Weil, Michael,Ullrich, Robert. Radiation Leukemogenesis at Low Dose Rates,2013.