Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs

GSTDTAP > 地球科学

DOI	10.2172/1037011
报告编号	DOEER64347
来源ID	OSTI ID: 1037011
	Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs
	Michael Cornforth
	2012-03-26
出版年	2012
语种	英语
国家	美国
领域	地球科学
英文摘要	Combining contemporary cytogenetic methods with DNA CGH microarray technology and chromosome flow-sorting increases substantially the ability to resolve exchange breakpoints associated with interstitial deletions and translocations, allowing the consequences of radiation damage to be directly measured at low doses, while also providing valuable insights into molecular mechanisms of misrepair processes that, in turn, identify appropriate biophysical models of risk at low doses. Specific aims apply to cells recovered from 3D tissue constructs of human skin and, for the purpose of comparison, the same cells irradiated in traditional 2D cultures. The project includes research complementary to NASA/HRP space radiation project.
英文关键词	Ionizing radiation chromosome aberrations low dose LET
URL	查看原文
来源平台	US Department of Energy (DOE)
引用统计
文献类型	科技报告
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/5730
专题	地球科学
推荐引用方式 GB/T 7714	Michael Cornforth. Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs,2012.