Conservation of Modules but not Phenotype in Bacterial Response to Environmental Stress

doi:10.2172/985921

GSTDTAP > 地球科学

DOI	10.2172/985921
报告编号	LBNL-3744E-Poster
来源ID	OSTI ID: 985921
	Conservation of Modules but not Phenotype in Bacterial Response to Environmental Stress
	Timberlake, Sonia; Joachimiak, Marcin; Joyner, Dominique; Chakraborty, Romy; Baumohl, Jason; Dehal, Paramvir; Arkin, Adam; Hazen, Terry; Alm, Eric
	2010-05-17
出版年	2010
语种	英语
国家	美国
领域	地球科学
英文摘要	Microbes live in changing environments and change their phenotype via gene regulation in response. Although this transcriptional response is important for fitness, very little is known about how it evolves in microbes. We started by asking a number of high-level questions about the evolution of transcriptional phenotype: (1) To what extent is transcriptional response conserved, i.e. do conserved genes respond similarly to the same condition; (2) To what extent are transcriptional modules conserved; and (3) Does there exist a general stress response to a variety of stressors? To illuminate these questions, we analyzed more than 500 microarray experiments across the bacterial domain. We looked for conservation of transcriptional regulation both in close sister species and vastly divergent clades. In addition, we produced and analyzed an extensive in-house compendium of environmental stress data in three metal-reducing bacteria.
英文关键词	transcriptional response general stress response transcriptional modules
URL	查看原文
来源平台	US Department of Energy (DOE)
引用统计
文献类型	科技报告
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/4821
专题	地球科学
推荐引用方式 GB/T 7714	Timberlake, Sonia,Joachimiak, Marcin,Joyner, Dominique,et al. Conservation of Modules but not Phenotype in Bacterial Response to Environmental Stress,2010.