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DOI | 10.1016/j.atmosres.2016.09.002 |
Scaling single-cell genomics from phenomenology to mechanism | |
Tanay, Amos1,2; Regev, Aviv3,4,5 | |
2017-01-19 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 541期号:7637页码:331-338 |
文章类型 | Review |
语种 | 英语 |
国家 | Israel; USA |
英文摘要 | Three of the most fundamental questions in biology are how individual cells differentiate to form tissues, how tissues function in a coordinated and flexible fashion and which gene regulatory mechanisms support these processes. Single-cell genomics is opening up new ways to tackle these questions by combining the comprehensive nature of genomics with the microscopic resolution that is required to describe complex multicellular systems. Initial single-cell genomic studies provided a remarkably rich phenomenology of heterogeneous cellular states, but transforming observational studies into models of dynamics and causal mechanisms in tissues poses fresh challenges and requires stronger integration of theoretical, computational and experimental frameworks. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396128800031 |
WOS关键词 | GENE-EXPRESSION DATA ; EMBRYONIC STEM-CELLS ; RNA-SEQ ; CHROMATIN ACCESSIBILITY ; MESSENGER-RNA ; HUMAN BRAIN ; IN-SITU ; TRANSCRIPTIONAL HETEROGENEITY ; EPIGENETIC HETEROGENEITY ; MAMMALIAN-CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/38052 |
专题 | 地球科学 |
作者单位 | 1.Weizmann Inst Sci, Dept Comp Sci & Appl Math, IL-76100 Rehovot, Israel; 2.Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel; 3.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; 4.MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02140 USA; 5.MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Tanay, Amos,Regev, Aviv. Scaling single-cell genomics from phenomenology to mechanism[J]. NATURE,2017,541(7637):331-338. |
APA | Tanay, Amos,&Regev, Aviv.(2017).Scaling single-cell genomics from phenomenology to mechanism.NATURE,541(7637),331-338. |
MLA | Tanay, Amos,et al."Scaling single-cell genomics from phenomenology to mechanism".NATURE 541.7637(2017):331-338. |
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