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DOI | 10.1289/EHP9833 |
Evaluation of Early Biomarkers of Atherosclerosis Associated with Polychlorinated Biphenyl Exposure: An in Vitro and in Vivo Study | |
Bingwei Yang; Zhishuai Ye; Yawen Wang; Hongzhou Guo; Hans-Joachim Lehmler; Rongchong Huang; Erqun Song; Yang Song | |
2022-03-29 | |
发表期刊 | Environmental Health Perspectives
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出版年 | 2022 |
英文摘要 | AbstractBackground:Miscellaneous cardiovascular risk factors have been defined, but the contribution of environmental pollutants exposure on cardiovascular disease (CVD) remains underappreciated. Objective:We investigated the potential impact of typical environmental pollutant exposure on atherogenesis and its underlying mechanisms. Methods:We used human umbilical vein endothelial cells (HUVECs) and apolipoprotein E knockout () mice to investigate how 2,3,5-trichloro-6-phenyl-[1,4]-benzoquinone (PCB29-pQ, a toxic polychlorinated biphenyl metabolite) affects atherogenesis and identified early biomarkers of CVD associated with PCB29-pQ exposures. Then, we used long noncoding RNAs (lncRNAs) HDAC7-AS1–overexpressing mice and apolipoprotein E/caveolin 1 double-knockout () mice to address the role of these early biomarkers in PCB29-pQ–induced atherogenesis. Plasma samples from patients with coronary heart disease (CHD) were also used to confirm our findings. Results:Our data indicate that lncRNA HDAC7-AS1 bound to MIR-7-5p via argonaute 2 in PCB29-pQ–challenged HUVECs. Our mRNA sequencing assay identified transforming growth () as a possible target gene of MIR-7-5p; HDAC7-AS1 sponged MIR-7-5p and inhibited the binding of to MIR-7-5p. The effect of PCB29-pQ–induced endothelial injury, vascular inflammation, development of plaques, and atherogenesis in mice was greater with MIR-7-5p–mediated inhibition, whereas HDAC7-AS1–overexpressing mice and mice showed the opposite effect. Consistently, plasma levels of HDAC7-AS1 and MIR-7-5p were found to be significantly associated individuals diagnosed with CHD. Discussions:These findings demonstrated that a mechanism-based, integrated-omics approach enabled the identification of potentially clinically relevant diagnostic indicators and therapeutic targets of CHD mediated by environmental contaminants using in vitro and in vivo models of HUVECs and and mice. https://doi.org/10.1289/EHP9833 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/347879 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Bingwei Yang,Zhishuai Ye,Yawen Wang,et al. Evaluation of Early Biomarkers of Atherosclerosis Associated with Polychlorinated Biphenyl Exposure: An in Vitro and in Vivo Study[J]. Environmental Health Perspectives,2022. |
APA | Bingwei Yang.,Zhishuai Ye.,Yawen Wang.,Hongzhou Guo.,Hans-Joachim Lehmler.,...&Yang Song.(2022).Evaluation of Early Biomarkers of Atherosclerosis Associated with Polychlorinated Biphenyl Exposure: An in Vitro and in Vivo Study.Environmental Health Perspectives. |
MLA | Bingwei Yang,et al."Evaluation of Early Biomarkers of Atherosclerosis Associated with Polychlorinated Biphenyl Exposure: An in Vitro and in Vivo Study".Environmental Health Perspectives (2022). |
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