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The last deglaciation was characterized by drastic climate changes, most prominently melting ice sheets. Melting ice sheets have a significant impact on the atmospheric and oceanic circulation, due to changes in the topography and meltwater release into the ocean. In a set of transient simulations of the last deglaciation with the Max Planck Institute Earth System Model (MPI-ESM) we explore differences in the climate response that arise from different boundary conditions and implementations suggested within the Paleoclimate Modelling Intercomparison Project - Phase 4 (PMIP4) deglaciation protocol. The underlying ice-sheet reconstruction dominates the simulated deglacial millennial-scale climate variability in terms of timing and occurrence of observed climate events. Sensitivity experiments indicate that the location and timing of meltwater release from the ice sheets into the ocean is crucial for the ocean response. The results will allow a better interpretation of inter-model differences that arise from different implementations proposed within the PMIP4 protocol.