Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP9467 |
Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey | |
Matthew C. Cave; Christina M. Pinkston; Shesh N. Rai; Banrida Wahlang; Marian Pavuk; Kimberly Z. Head; Gleta K. Carswell; Gail M. Nelson; Carolyn M. Klinge; Douglas A. Bell; Linda S. Birnbaum; Brian N. Chorley | |
2022-01-06 | |
发表期刊 | Environmental Health Perspectives
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出版年 | 2022 |
英文摘要 | AbstractBackground:Polychlorinated biphenyl (PCB) exposures have been associated with liver injury in human cohorts, and steatohepatitis with liver necrosis in model systems. MicroRNAs (miRs) maintain cellular homeostasis and may regulate the response to environmental stress. Objectives:We tested the hypothesis that specific miRs are associated with liver disease and PCB exposures in a residential cohort. Methods:Sixty-eight targeted hepatotoxicity miRs were measured in archived serum from 734 PCB-exposed participants in the cross-sectional Anniston Community Health Survey. Necrotic and other liver disease categories were defined by serum keratin 18 (K18) biomarkers. Associations were determined between exposure biomarkers (35 ortho-substituted PCB congeners) and disease biomarkers (highly expressed miRs or previously measured cytokines), and Ingenuity Pathway Analysis was performed. Results:The necrotic liver disease category was associated with four up-regulated miRs (miR-99a-5p, miR-122-5p, miR-192-5p, and miR-320a) and five down-regulated miRs (let-7d-5p, miR-17-5p, miR-24-3p, miR-197-3p, and miR-221-3p). Twenty-two miRs were associated with the other liver disease category or with K18 measurements. Eleven miRs were associated with 24 PCBs, most commonly congeners with anti-estrogenic activities. Most of the exposure-associated miRs were associated with at least one serum hepatocyte death, pro-inflammatory cytokine or insulin resistance bioarker, or with both. Within each biomarker category, associations were strongest for the liver-specific miR-122-5p. Pathways of liver toxicity that were identified included inflammation/hepatitis, hyperplasia/hyperproliferation, cirrhosis, and hepatocellular carcinoma. Tumor protein p53 and tumor necrosis factor were well integrated within the top identified networks. Discussion:These results support the human hepatotoxicity of environmental PCB exposures while elucidating potential modes of PCB action. The MiR-derived liquid liver biopsy represents a promising new technique for environmental hepatology cohort studies. https://doi.org/10.1289/EHP9467 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/345046 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Matthew C. Cave,Christina M. Pinkston,Shesh N. Rai,et al. Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey[J]. Environmental Health Perspectives,2022. |
APA | Matthew C. Cave.,Christina M. Pinkston.,Shesh N. Rai.,Banrida Wahlang.,Marian Pavuk.,...&Brian N. Chorley.(2022).Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey.Environmental Health Perspectives. |
MLA | Matthew C. Cave,et al."Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey".Environmental Health Perspectives (2022). |
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