Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41558-018-0161-6 |
Antibiotic resistance increases with local temperature | |
MacFadden, Derek R.1,2,3; McGough, Sarah F.2,4; Fisman, David1; Santillana, Mauricio1,3,4,5; Brownstein, John S.3,4,5 | |
2018-06-01 | |
发表期刊 | NATURE CLIMATE CHANGE |
ISSN | 1758-678X |
EISSN | 1758-6798 |
出版年 | 2018 |
卷号 | 8期号:6页码:510-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; USA |
英文摘要 | Bacteria that cause infections in humans can develop or acquire resistance to antibiotics commonly used against them(1,2). Antimicrobial resistance (in bacteria and other microbes) causes significant morbidity worldwide, and some estimates indicate the attributable mortality could reach up to 10 million by 2050(2-4). Antibiotic resistance in bacteria is believed to develop largely under the selective pressure of antibiotic use; however, other factors may contribute to population level increases in antibiotic resistanc(1,2). We explored the role of climate (temperature) and additional factors on the distribution of antibiotic resistance across the United States, and here we show that increasing local temperature as well as population density are associated with increasing antibiotic resistance (percent resistant) in common pathogens. We found that an increase in temperature of 10 degrees C across regions was associated with an increases in antibiotic resistance of 4.2%, 2.2%, and 2.7% for the common pathogens Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. The associations between temperature and antibiotic resistance in this ecological study are consistent across most classes of antibiotics and pathogens and may be strengthening over time. These findings suggest that current forecasts of the burden of antibiotic resistance could be significant underestimates in the face of a growing population and climate change(4). |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000433904400023 |
WOS关键词 | TRANSMISSION DYNAMICS ; ESCHERICHIA-COLI ; POPULATION ; ENVIRONMENT |
WOS类目 | Environmental Sciences ; Environmental Studies ; Meteorology & Atmospheric Sciences |
WOS研究方向 | Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/34404 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Toronto, Div Infect Dis, Dept Med, Toronto, ON, Canada; 2.Harvard Univ, Harvard Chan Sch Publ Hlth, Boston, MA 02115 USA; 3.Boston Childrens Hosp, Computat Epidemiol Grp, Boston, MA 02115 USA; 4.Boston Childrens Hosp, Computat Hlth Informat Program, Boston, MA 02115 USA; 5.Harvard Univ, Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | MacFadden, Derek R.,McGough, Sarah F.,Fisman, David,et al. Antibiotic resistance increases with local temperature[J]. NATURE CLIMATE CHANGE,2018,8(6):510-+. |
APA | MacFadden, Derek R.,McGough, Sarah F.,Fisman, David,Santillana, Mauricio,&Brownstein, John S..(2018).Antibiotic resistance increases with local temperature.NATURE CLIMATE CHANGE,8(6),510-+. |
MLA | MacFadden, Derek R.,et al."Antibiotic resistance increases with local temperature".NATURE CLIMATE CHANGE 8.6(2018):510-+. |
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