Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP9256 |
Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure | |
Khursheed Iqbal; Stephen H. Pierce; Keisuke Kozai; Pramod Dhakal; Regan L. Scott; Katherine F. Roby; Carrie A. Vyhlidal; Michael J. Soares | |
2021-11-08 | |
发表期刊 | Environmental Health Perspectives |
出版年 | 2021 |
英文摘要 | AbstractBackground:Our environment is replete with chemicals that can affect embryonic and extraembryonic development. Dioxins, such as 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD), are compounds affecting development through the aryl hydrocarbon receptor (AHR). Objectives:The purpose of this investigation was to examine the effects of TCDD exposure on pregnancy and placentation and to evaluate roles for AHR and cytochrome P450 1A1 (CYP1A1) in TCDD action. Methods:Actions of TCDD were examined in wild-type and genome-edited rat models. Placenta phenotyping was assessed using morphological, biochemical, and molecular analyses. Results:TCDD exposures were shown to result in placental adaptations and at higher doses, pregnancy termination. Deep intrauterine endovascular trophoblast cell invasion was a prominent placentation site adaptation to TCDD. TCDD-mediated placental adaptations were dependent upon maternal AHR signaling but not upon placental or fetal AHR signaling nor the presence of a prominent AHR target, CYP1A1. At the placentation site, TCDD activated AHR signaling within endothelial cells but not trophoblast cells. Immune and trophoblast cell behaviors at the uterine–placental interface were guided by the actions of TCDD on endothelial cells. Discussion:We identified an AHR regulatory pathway in rats activated by dioxin affecting uterine and trophoblast cell dynamics and the formation of the hemochorial placenta. https://doi.org/10.1289/EHP9256 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/340751 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Khursheed Iqbal,Stephen H. Pierce,Keisuke Kozai,et al. Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure[J]. Environmental Health Perspectives,2021. |
APA | Khursheed Iqbal.,Stephen H. Pierce.,Keisuke Kozai.,Pramod Dhakal.,Regan L. Scott.,...&Michael J. Soares.(2021).Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure.Environmental Health Perspectives. |
MLA | Khursheed Iqbal,et al."Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure".Environmental Health Perspectives (2021). |
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