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The Roundtable on Obesity Solutions of the Health and Medicine Division of the National Academies of Sciences, Engineering, and Medicine held a virtual public workshop, Leveraging Health Communication, Data, and Innovative Approaches for Sustainable Systems-Wide Changes to Reduce the Prevalence of Obesity, on June 22, 2021. The workshop, the second in a series of three workshops to examine foundational drivers of obesity and sustainable systems-wide changes to reduce the prevalence of obesity, explored strategies for leveraging health communication and data-informed, innovative approaches. Participants in the workshop discussed how health communication might enhance the understanding and the use of current modeling and data-driven efforts to advance obesity solutions; they also explored innovative data and policy approaches for obesity solutions. This Proceedings of a Workshop-in Brief highlights the presentations and discussions that occurred at the workshop.