Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1787/b9c4bdb2-en |
Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy | |
Shihori Tanabei; Akihiko Hirosei and Takashi YamadaiiNational Institute of Health Sciences | |
2021-10-15 | |
出版年 | 2021 |
国家 | 国际 |
领域 | 气候变化 ; 资源环境 |
英文摘要 | The present AOP describes inhibition of histone deacetylase resulting in testicular atrophy. Histone deacetylase inhibitors (HDIs) are approved as anti-cancer drugs since HDIs have apoptotic effects in cancer cells. The intracellular mechanisms of induction of the spermatocyte apoptosis by HDIs are suggested as histone deacetylase (HDAC) inhibition as MIE, histone acetylation increase, disrupted cell cycle, apoptosis, and spermatocyte depletion as KEs. The adverse outcome has been defined as testicular atrophy. The HDIs inhibit deacetylation of the histone, leading to an increase in histone acetylation. The apoptosis induced by disrupted cell cycle leads to spermatocyte depletion and testis atrophy. Testicular toxicity is of interest for human health risk assessment especially in terms of reproductive and developmental toxicity, however, the testicular toxicity has not been fully elucidated. This AOP may be one of the pathways induced by HDIs, which suggests the pathway networks of protein hyperacetylations. |
URL | 查看原文 |
来源平台 | OECD iLibrary |
引用统计 | |
文献类型 | 科技报告 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/339995 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Shihori Tanabei,Akihiko Hirosei ,and ,et al. Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy,2021. |
条目包含的文件 | 条目无相关文件。 |
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