Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP9449 |
Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults | |
Scott Weichenthal; Eric Lavigne; Alison Traub; Dana Umbrio; Hongyu You; Krystal Pollitt; Tim Shin; Ryan Kulka; Dave M. Stieb; Jill Korsiak; Barry Jessiman; Jeff R. Brook; Marianne Hatzopoulou; Greg Evans; Richard T. Burnett | |
2021-10-13 | |
发表期刊 | Environmental Health Perspectives |
出版年 | 2021 |
英文摘要 | AbstractBackground:We do not currently understand how spatiotemporal variations in the composition of fine particulate air pollution [fine particulate matter with aerodynamic diameter ()] affects population health risks. However, recent evidence suggests that joint concentrations of transition metals and sulfate may influence the oxidative potential (OP) of and associated health impacts. Objectives:The purpose of the study was to evaluate how combinations of transition metals/OP and sulfur content in outdoor influence associations with acute cardiovascular events. Methods:We conducted a national case-crossover study of outdoor and acute cardiovascular events in Canada between 2016 and 2017 (93,344 adult cases). Monthly mean transition metal and sulfur (S) concentrations in were determined prospectively along with estimates of OP using acellular assays for glutathione (), ascorbate (), and dithiothreitol depletion (). Conditional logistic regression models were used to estimate odds ratios (OR) [95% confidence intervals (CI)] for across strata of transition metals/OP and sulfur. Results:Among men, the magnitudes of observed associations were strongest when both transition metal and sulfur content were elevated. For example, an OR of 1.078 (95% CI: 1.049, 1.108) (per ) was observed for cardiovascular events in men when both copper and S were above the median, whereas a weaker association was observed when both elements were below median values (, 95% CI: 1.007, 1.031). A similar pattern was observed for OP metrics. was not associated with acute cardiovascular events in women. Discussion:The combined transition metal and sulfur content of outdoor influences the strength of association with acute cardiovascular events in men. Regions with elevated concentrations of both sulfur and transition metals in should be examined as priority areas for regulatory interventions. https://doi.org/10.1289/EHP9449 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/339737 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Scott Weichenthal,Eric Lavigne,Alison Traub,et al. Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults[J]. Environmental Health Perspectives,2021. |
APA | Scott Weichenthal.,Eric Lavigne.,Alison Traub.,Dana Umbrio.,Hongyu You.,...&Richard T. Burnett.(2021).Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults.Environmental Health Perspectives. |
MLA | Scott Weichenthal,et al."Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults".Environmental Health Perspectives (2021). |
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